DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Dlg5

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	1562	Identity:	296/1562 - (18%)
Similarity:	488/1562 - (31%)	Gaps:	494/1562 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 MILSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQH-------------LQHQQQQQPLR 133
            ::..|....:...|...||........|.|.|..:|..::.             .:.|...|.||
Mouse     8 LLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLQLLLAKEQDHFQDLR 72

  Fly   134 TATPTCLLSGRQTPSAISVMSLQEATSLHRQQQQPHQPPTIYV------PVPTK-LGNNVN---- 187
            .|.                           ::.|||..|.:|:      |..|: .|:..:
Mouse    73 AAL---------------------------EKTQPHLLPILYLNGVVGPPQSTEGAGSTYSVLSI 110

  Fly   188 --TGNSSATLLLSYGSTSSIAN---LQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASGGAS 247
              :.:.|::.|.|.|:|....:   |..:||.:.......:..||.....:.|.::.:.|:.||:
Mouse   111 MPSDSESSSSLSSVGTTGKAPSPPPLLTEQQANDTVENLSIQLRLMTRERNELRKRLAFATHGAT 175

  Fly   248 SNKSSLSLTPNGHL-PDYKLVTAMPVVVLDD------EHKSNSLPATEASRNSNSSSNMNGSSNS 305
            .:|     .|...| |||:.:....|..:.|      :|.:......|.::.::....::....|
Mouse   176 FDK-----RPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLS 235

  Fly   306 NSLDVSNSNSHSGSSTSLASTTRNVF--TWG--KRM----SRKLDLLKRSDSPAAAHKSHSDLRS 362
            :...:.:...............||:.  :|.  ||:    .:::..|:........|...|::.:
Mouse   236 DQTQLKDDVDMLRRENGKLRRERNLLQQSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEILN 300

  Fly   363 LFHSPTHHKSGSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQ 427
            ..:.....|.........:..|..:.....|    .|..|.|::.........||.....||:..
Mouse   301 KLYDTAMDKLEVVKKDYDALRKRYSEKVAMH----NSDLSRLEQLGEENQRLQKQTEMLTQQRDT 361

  Fly   428 SVQDVGTGQSQSAQS-----TPTHQFQAAARPQKALKNFFHRIGS-TGMLNHRSHNLLKASEAAQ 486
            ::|    .|.|.|.|     |..|:...|....|.|:.....:.| ...|..:.....|.||..:
Mouse   362 AIQ----LQHQCALSLRRFETIHHELSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYK 422

  Fly   487 QATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSSCL 551
            :...|..:.|:                       |...:|:|.:..:..|::    ::....|.|
Mouse   423 EERDAVYSEYK-----------------------LIMSERDQVISELDKLQT----EVELAESKL 460

  Fly   552 TASTSSGSAAG----SLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNV 612
            .:|||...||.    :|.....:.....|            |.......||.:...|.:|
Mouse   461 KSSTSEKKAASEEMEALRQIKDTVTMDAG------------RANKEVEILRKQCKALCQE----- 508

  Fly   613 PGHLKQQIQ-----RQREQHQQHQRDLLQQEQTS-----SPLPQRRSPEQAMLNNVSRNDSITSK 667
               ||:.:|     :.|......:||.:..|:.|     ..|.:.|....:.|....|:...|.|
Mouse   509 ---LKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRK 570

  Fly   668 ---DWEPLYQRLSSCL---------------------SSNESGYDSDG----------------- 691
               |.....:.|:||:                     ||::|..|:|.
Mouse   571 QKNDVSRELKELNSCVHREQMECQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDI 635

  Fly   692 --GATGARLGNNLS-----------ISGGDTESIASGTL------------------KRNSLISL 725
              .|.|..:...::           ::..|..|||.|.|                  |:.::.:|
Mouse   636 DLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKAL 700

  Fly   726 SSSEG-VGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIG 789
            .:.|| :.|.:.....||     ...:....::|.|      .:..|.:...:.||.       |
Mouse   701 LNGEGAINMVVRRRKSLG-----GKVVTPLHINLSG------QKGSRPQDSGISLEN-------G 747

  Fly   790 IVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSS 854
            :               |...:|   |...|.|:|.|.:||.||.:||..|.. :|..|.:.||.|
Mouse   748 V---------------YAAAVV---PGSPAAKEGSLAVGDRIVAINGIALDN-KSLNECESLLRS 793

  Fly   855 FVD-----------------------NCIDL--------------------VIAHDEVTTVTDFY 876
            ..|                       |..|.                    ::.|:..|....||
Mouse   794 CQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNSTQTDIFY 858

  Fly   877 TKIRID---------GMSTQRHR-----LSYV--QRTQSTD--SLSSMQS----------LQLQQ 913
            |. |::         |.|:..|:     .|.|  |...||.  ||:|.:|          :.::.
Mouse   859 TD-RLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQACPSTSERSLNSFRSDTSAERGYGLVDMRS 922

  Fly   914 ER-IQGHNTEQEQEAQGE---DQCDARSMASVSTMP----------------------------- 945
            :| :....||.......|   |:.|.....|..|.|
Mouse   923 QRPLLSFETEVGPCGAVEVPLDKIDPEGSNSGGTWPKAVLGSTSGPEKLSVYKKPKQRKSIFDPN 987

  Fly   946 --------------TPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALT----PTP 992
                          .|.|.:.|    :|:.|..||:.......||:.|...|..|..:    .|.
Mouse   988 TFKRPQTPPKIDYLLPGPGLTH----SPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATL 1048

  Fly   993 LFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSL---ADDEKWQLLARKRC 1054
            :.:|.|:|..|:|...:     ||:..|.:..|    |.|.|.:|||.   .|.:...|.|:|.|
Mouse  1049 VGSSPSTSPPSAPPPSM-----DPSEPTHASPP----RKARVRIASSYHSEGDGDTSYLPAKKPC 1104

  Fly  1055 SEG-----------------SALSATPN------PQQF--GQRTHYARNSINLANSHYRSLRFAH 1094
            .|.                 ||.|..|.      |.|.  .|....|...::.....:......|
Mouse  1105 DEDLTSQKVDELGQKRRRPKSAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGH 1169

  Fly  1095 SRLSSSRLSLFMQAP-----PNSLTVGEGVAN--------------TPSSTATTTTDLTNQQQQQ 1140
            :....:.| |:...|     |.|:|.|..|.:              .|..:.....|..:|....
Mouse  1170 ASRHGNPL-LYPNRPSVGTVPRSMTPGTTVGSILRNPIYTVRSHRVLPCGSPPVPRDAGSQSLSP 1233

  Fly  1141 QNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSS-------------LAP--P 1190
            ..|.|...||.:.|  ::.|.:|.   :.||....|..:||..|||             |.|  |
Mouse  1234 SVQHQGRLSLDLSH--RACSDYSE---MRASQGSNSLPSSARLGSSSNLQFKAERIKIPLTPRYP 1293

  Fly  1191 AAALMHHRPSL--------PVAKLTI-------RDEEMAEVI-RASMSEGSGRCTPKTITFFKGP 1239
            .:.:...|.||        |.:.|.|       :.:..|..: |.:::..|.....|...|.:.|
Mouse  1294 RSVMGSDRGSLSHSECSTPPRSPLNIDTLSSCSQPQTTASTLPRIAVNPSSHGERRKDRPFVEEP 1358

  Fly  1240 -------GLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSH 1297
                   |.:.||.|||.|.   ||  |::|..| ..|..|....|:.||:::|.||.:::..:.
Mouse  1359 RHVKVQKGSEPLGISIVSGE---KG--GVYVSKV-TLGSIAHQAGLEYGDQLLEFNGINLRSATE 1417

  Fly  1298 AE 1299
            .:
Mouse  1418 QQ 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	25/132 (19%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	23/77 (30%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141	18/88 (20%)
		Smc	<141..564	CDD:224117	82/482 (17%)
		PDZ_signaling	625..712	CDD:238492	13/86 (15%)
		PDZ_signaling	<741..800	CDD:238492	23/84 (27%)
		PDZ	1357..1439	CDD:214570	21/69 (30%)
		dbPDZ_assoc	1437..1512	CDD:374667
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900