DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Pdzph1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	1291	Identity:	235/1291 - (18%)
Similarity:	390/1291 - (30%)	Gaps:	451/1291 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 TCLLSGRQTPSAISVMSLQEATSLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLSYGST 202
            |...||:..|.  :|..|:|....|..:...||..|        ||.....|:.:.|
Mouse     8 TSQTSGQVCPQ--NVKDLEEDIKGHTSETVFHQTRT--------LGKLKENGDENIT-------- 54

  Fly   203 SSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASGGASSNKSSLSLTPNGHLP---DY 264
               |::..:|                  :||.|.:....|...::.:||    ..||:.|   ..
Mouse    55 ---ASINGKQ------------------NSSFLVKNEKQAPSDSTIHKS----MENGYTPPAISP 94

  Fly   265 KLVTAMPVVVLDDEHKSNSLPATEASRN-SNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTR 328
            :|...:||.:.:|..|  |||....:.: .|:...:..:......:|.     .|:......||:
Mouse    95 QLEEVLPVAMFNDREK--SLPGKITTEDFPNTVEVLKPAKGKFIREVK-----CGAFNVHVETTK 152

  Fly   329 NVF--TWGKRMSRK-----------LDLLKRSDSPAAAHKSHSDLRSLF--HSPTHHKSGSGGSS 378
            ::|  |..:.::::           ..:.:.|.|.....|..:.|...|  ..|:.::.|...|.
Mouse   153 SIFCKTGAQNLTKRRCPTCHQHYSVQQVWRGSKSRGHFSKHRTVLAEEFKRRVPSTYRRGVSRSE 217

  Fly   379 GPS---------------SAKASASPTGGHQNSSGSTT----STLKKCKSGPIETI--------- 415
            .||               |.|.:......|.||.|..|    ..||.....|.|:.
Mouse   218 VPSVNISIVGKEIMVEYISKKQNTFINICHPNSIGKLTKHRRGPLKHTTDEPCESASQPGINHPE 282

  Fly   416 KQRHQQQQQQQQSVQD----VGTGQSQSAQ------STP-----------------THQFQAAAR 453
            .||.:.|.|...:..|    |...|.:::.      |:|                 :.:.::|..
Mouse   283 NQRLENQHQSSDAFHDAPCSVNAVQKENSDTIVVSLSSPPRREKEKPNTLPSAPDDSEEGESATS 347

  Fly   454 PQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSSTS--QLSSSSYVKCDDPT 516
            |||.|     :|.....|.....       .|....|.::...|::|.:  .||..|.....|..
Mouse   348 PQKVL-----QITQDKPLEQHCF-------TADSCLPTSSETLRTTSLNNVDLSKMSLEDSRDVD 400

  Fly   517 EGLNLQREQREQRLP--RIASLKSSSCDDIAKVSSCLTASTSSGSAAGS--------LGSPPSSA 571
            |......:.||...|  ::....:.:...::.|:|.:....:|||....        ||:...:.
Mouse   401 EERKNSSDVRENITPDSQVQPCTAGTNGPLSAVNSIIPIQDASGSEFSPLSFLTLQLLGAKADNM 465

  Fly   572 AAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVL------------PEENHGNVPGHLKQQIQRQR 624
            ...|..|.....|:.|....||.:...::.|.|            |.|..||. ....|.|..:|
Mouse   466 GCRGEETLPGEGHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNT-FSFSQYIGVER 529

  Fly   625 EQHQQHQRDL----LQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNE- 684
            ||.:.|.|.:    |..:.:|:..|..|...|:....::....:..|  .||:..:.|.:..|:
Mouse   530 EQEKVHYRLINKASLHNDSSSNIQPLERKDPQSPAVTIASCSILVPK--SPLHGNIHSSVEWNQT 592

  Fly   685 ---SGYDSDGGATGARLGNNLSISGGDTESIASGTLK------------RNSLISLSSSEGVGMG 734
               :.:....|.:...:....||:....:|:|:...|            ||...|.|..|.||..
Mouse   593 EDHANHAERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENVGDD 657

  Fly   735 MGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMT 799
            ...:|    |..:|  :|                  .|.|..  |.|:.|.:    :.|....:.
Mouse   658 ASQAL----PVVKN--MC------------------HRNFED--LTRENQNE----ICSQMDFLQ 692

  Fly   800 NSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVI 864
            ||:|..           .:.....:|.|                                ||..:
Mouse   693 NSSEST-----------SVGHTTEKLFL--------------------------------IDKTL 714

  Fly   865 AHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQG 929
            |.|:             |..|.:.|:         |..|::     .|||..:...|  ......
Mouse   715 ASDD-------------DSNSNRDHK---------TCGLNN-----FQQEPAECQRT--TSRVYC 750

  Fly   930 EDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAP---EHELLRRRARSSSGQRSLALTPT 991
            |:..:.|....||..|..:.|...::.:....:|::..|   ..||..|..|:|.|.:..|:
Mouse   751 EESGNQRYPTEVSCHPVDILLSPQKQKALKDQNLEINNPRKLSQELALRGGRASDGSQEEAI--- 812

  Fly   992 PLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSE 1056
                                                                |:|   ||:|
Mouse   813 ----------------------------------------------------EQW---ARRR--- 819

  Fly  1057 GSALSATPNPQQF--GQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGV 1119
                      |||  |:|...|..|..::|       |....::|..:        :|:..|..|
Mouse   820 ----------QQFKDGKRCSSAGGSSVISN-------FTEGSITSDDV--------HSVDFGFRV 859

  Fly  1120 ANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAG 1184
                        |:..:....:|   .|.:.::......          |...||...|
Mouse   860 ------------DIEEKGFYTEN---FHSTAWVFRGDDG----------NPEDSPRCLS------ 893

  Fly  1185 SSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIV 1249
                         :...|||   :|:                    :|:..|||.|....||.|.
Mouse   894 -------------KKPRPVA---VRE--------------------RTVRLFKGTGDYPWGFRIQ 922

  Fly  1250 GGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFK 1305
            ..:.        .|.|...:..||::..||.||.::.:||..|..:.|||.:.|.|
Mouse   923 FSKP--------IVVTEVDTNSAAEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAK 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	11/89 (12%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	24/76 (32%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	24/96 (25%)
		PH-like	986..1093	CDD:302622
		PH	993..1094	CDD:278594
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900