DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	801	Identity:	168/801 - (20%)
Similarity:	257/801 - (32%)	Gaps:	286/801 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 GNVP-----GHLKQQIQRQREQHQQHQRDL----LQQEQTSSPLPQ----RRSPEQAMLN----- 656
            ||:|     |. |::..::|:.||....|:    :.:.:.:||..:    |...|...||
Mouse    88 GNIPVFGDYGE-KRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMV 151

  Fly   657 --NVSRNDSITSKDWE---------PLYQRLSSCLSSNESGYDSDGGATGA-RLGNNLSISGGDT 709
              :||....:..:.|.         ..:::.:....:..||..|:.|.|.. .||:..|..|..|
Mouse   152 GVDVSGASYLAEQCWNGGFIYLIMLRRFKQKAHLTYNGNSGNSSEPGETPTLELGDQTSKKGKRT 216

  Fly   710 ESIASGTLKRNSLISL----SSSEG------------------VGMGMGMSLGLGAPSTRNSS-- 750
            ...  |.:.|.::|..    .|:.|                  :|.|....|..|..|.::.:
Mouse   217 RKF--GVISRPAIIKAPEDSKSNSGCDTADDPSSELENGTDSELGNGHAFELENGPNSLKDVAGP 279

  Fly   751 ----------------ICSAPVS----------LGGYNYDYETETIRRRFRQV-KLERKCQEDYI 788
                            ...||:|          .|..|:.......|....:: |:|...:.|.:
Mouse   280 HLERSEADREAELRVPKTEAPLSDSNDKRRFSKTGKTNFQSSDSLAREEVGRIWKMELLKESDGL 344

  Fly   789 GIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLS 853
            ||.:|..   ..|....:..::.:::..|.|.:||||.||||::.:||..|.|: |..|...:|.
Mouse   345 GIQVSGG---RGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGL-SHEEAVAILR 405

  Fly   854 SFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQG 918
            | ....:.||:|..|                |:....|....:        |:..|....|.|..
Mouse   406 S-ATGMVQLVVASKE----------------SSAEDLLKLTSK--------SLPDLTSSVEDISS 445

  Fly   919 HNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQ 983
            ....::|||..:|:....|.|...||            .....|.|||:.|............|.
Mouse   446 WTDNEDQEAARDDEEGTGSAAVRGTM------------LGSEESQDVGSSEESKGNNLESPKQGN 498

  Fly   984 RSLALTPTPLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQL 1048
            ..:.|          .|..|...|||        ...:.|..:.....           |.:.::
Mouse   499 SKMKL----------KSRLSGGVHRL--------ESVEEYNELMVRNG-----------DPRIRM 534

  Fly  1049 LARKRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSL 1113
            |...|.....:|     ||..
Mouse   535 LEVSRDGRKHSL-----PQLL-------------------------------------------- 550

  Fly  1114 TVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASAS 1178
                      .||.|:              |:.|   .:|.|.:|:|
Mouse   551 ----------DSTGTS--------------QEYH---IVKKSTRSLS------------------ 570

  Fly  1179 TSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKS 1243
                                        |...|....:||.|:.        ..|..:|..| |.
Mouse   571 ----------------------------TTHVESPWRLIRPSVI--------SIIGLYKEKG-KG 598

  Fly  1244 LGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVR 1308
            |||||.||||..:|.|||||||:||:|.||:||.|:.||||:::||..::|::..|.|..||.:|
Mouse   599 LGFSIAGGRDCVRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIR 663

  Fly  1309 EGTIVLKILRRKLQKAKSMGC 1329
            .|..||.: |.||.......|
Mouse   664 SGLFVLTV-RTKLLSPSLTPC 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	27/90 (30%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	44/86 (51%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492	26/85 (31%)
		PDZ_signaling	591..672	CDD:238492	43/82 (52%)
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8130
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43986
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9923
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.890