DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	167/773 - (21%)
Similarity:	254/773 - (32%)	Gaps:	291/773 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 GAFPYAFL----RSRLSVLPEENHGN--VPGH---LKQQIQRQREQHQQHQRDLLQQEQTSSPLP 645
            |.|.|..:    :.:..|....|.||  .||.   |:...|..::..:..:..::.:...|
  Rat   168 GGFIYLIMLRRFKQKAHVTYNGNSGNSSEPGETPTLELGDQTSKKGKRTRKFGVISRPSIS---- 228

  Fly   646 QRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNN--LSISGG- 707
              ::||          ||.:|          |.|.::::...:.:.|| ...|||.  ..:..|
  Rat   229 --KTPE----------DSKSS----------SGCDTADDPNSELENGA-DPELGNGHAFELENGP 270

  Fly   708 -DTESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIR 771
             ..:.:|...|:|    |.:.||         :.|..|.|      .||:|         ....:
  Rat   271 HSLKDVAGPHLER----SEADSE---------VELRVPKT------EAPLS---------DSNDK 307

  Fly   772 RRFRQV--------------------KLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPY 816
            |||.:.                    |:|...:.|.:||.:|..   ..|....:..::.:::..
  Rat   308 RRFSKTGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGG---RGSKRSPHAIVVTQVKEG 369

  Fly   817 GMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRI 881
            |.|.:||||.||||::.:||..|.|: |..|...:|.| ....:.||:|..|
  Rat   370 GAAHRDGRLSLGDELLVINGHLLVGL-SHEEAVAILRS-ATGMVQLVVASKE------------- 419

  Fly   882 DGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPT 946
               |:....|....:        |:..|....|.:......::|||.|||:..:...|...|||
  Rat   420 ---SSAEDLLKLTSK--------SLPDLTSSVEDMSSWTDNEDQEAAGEDEEGSGPAAVRVTMP- 472

  Fly   947 PMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLD 1011
                       ....|.|||:.|         .|.|.         |.:....:|.:....||..
  Rat   473 -----------GSEESQDVGSSE---------ESKGN---------LESPKQGNCKTKLKSRLSG 508

  Fly  1012 NENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYA 1076
            .               .:|..||        :|..:|:.|.
  Rat   509 G---------------VHRLESV--------EEYNELMVRN------------------------ 526

  Fly  1077 RNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQ 1141
                  .:...|.|..:......|...|.                  .||.|:
  Rat   527 ------GDPRIRMLEVSRDGRKHSLPQLL------------------DSTGTS------------ 555

  Fly  1142 NQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKL 1206
              |:.|   .:|.|.:|:|
  Rat   556 --QEYH---IVKKSTRSLS---------------------------------------------- 569

  Fly  1207 TIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQ 1271
            |...|....:||.|:.        ..|..:|..| |.|||||.||||..:|.|||||||:||:|.
  Rat   570 TTHVESPWRLIRPSVI--------SIIGLYKEKG-KGLGFSIAGGRDCIRGQMGIFVKTIFPNGS 625

  Fly  1272 AADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKLQKAKSMGC 1329
            ||:||.|:.||||:::||..::|::..|.|..||.:|.|..||.: |.||.......|
  Rat   626 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV-RTKLLSPSLTPC 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	27/109 (25%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	44/86 (51%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492	26/85 (31%)
		PDZ_signaling	590..671	CDD:238492	43/82 (52%)
		PDZ_signaling	729..813	CDD:238492
		PHA03247	<985..1446	CDD:223021
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7902
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46076
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810