DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and GOPC

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_065132.1	Gene:	GOPC / 57120	HGNCID:	17643	Length:	462	Species:	Homo sapiens

Alignment Length:	658	Identity:	115/658 - (17%)
Similarity:	202/658 - (30%)	Gaps:	256/658 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 SSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQDVG--TGQSQS 439
            :.||..|.|...| ||...|.|:         .|.:...:.....:::..::..||.  .|:...
Human     3 AGGPCPAAAGGGP-GGASCSVGA---------PGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDP 57

  Fly   440 AQSTPTHQFQAAARPQKALKNFF----HRIGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSS 500
            .|:..|::   ..:...:|.:.|    |:..|...:||:    |:|
Human    58 DQADITYE---GRQKMTSLSSCFAQLCHKAQSVSQINHK----LEA------------------- 96

  Fly   501 TSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSGSAAGSLG 565
              ||........:...|.:.|::|..:|.|    .|.|......||...    |..||:....|.
Human    97 --QLVDLKSELTETQAEKVVLEKEVHDQLL----QLHSIQLQLHAKTGQ----SADSGTIKAKLS 151

  Fly   566 SPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEEN----------HGNVPG------ 614
            .|.....        ..:.:.:::.....|.|.:.:.:|.:||          ...|.|
Human   152 GPSVEEL--------ERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAK 208

  Fly   615 HLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNN-------VSRNDSITSKDWEPL 672
            :|.:::..:.:|.|...||:             :.|....|.|       :.|:.::
Human   209 YLDKELAGRVQQIQLLGRDM-------------KGPAHDKLWNQLEAEIHLHRHKTV-------- 252

  Fly   673 YQRLSSCLSSNE--------SGYDSDGGATGARLGNNLSISGGDTESIASGTLKRNSLISLSSSE 729
               :.:|...|:        .|:|.|                                 ||..|:
Human   253 ---IRACRGRNDLKRPMQAPPGHDQD---------------------------------SLKKSQ 281

  Fly   730 GVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSP 794
            |||                      |:                  |:|.|   .:||:.|:.:|
Human   282 GVG----------------------PI------------------RKVLL---LKEDHEGLGIS- 302

  Fly   795 KTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNC 859
               :|...|.....||.|:.|...|.:.|.|.:||.|:.|||.:||..:
Human   303 ---ITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTK---------------- 348

  Fly   860 IDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTE-- 922
                  |.|..|:           :|.||..:.:.....:.:..|..::::.:.|  .||...
Human   349 ------HKEAVTI-----------LSQQRGEIEFEVVYVAPEVDSDDENVEYEDE--SGHRYRLY 394

  Fly   923 -QEQEAQGEDQCDARSMASVSTMPTPMPLMQ--HRRSSTPRHS-----------LDVGAPE---- 969
             .|.|..|...      ||.......:.::|  ::::.|..|.           ||.||.:
Human   395 LDELEGGGNPG------ASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDL 453

  Fly   970 HELLRRRA 977
            |.|..:::
Human   454 HTLYHKKS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	24/89 (27%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
GOPC	NP_065132.1	bZIP_2	<166..199	CDD:285017	5/32 (16%)
		PDZ_signaling	286..368	CDD:238492	30/139 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..449		6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900