DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and pdzd2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_003198698.3	Gene:	pdzd2 / 569088	ZFINID:	ZDB-GENE-060526-297	Length:	2433	Species:	Danio rerio

Alignment Length:	779	Identity:	174/779 - (22%)
Similarity:	265/779 - (34%)	Gaps:	297/779 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 PPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQ 631
            ||.:.:.||.....|..|   ||.             :..|..|: |.|..|..:|.|:
Zfish   194 PPCNGSNGGNFVDVSNDH---RRS-------------VSSETAGS-PTHNGQNGKRTRK------ 235

  Fly   632 RDLLQQEQTSSPLPQRRSPEQAMLNNVSRN----DSITSKDWEPLYQRLSSCLSSNESGYDSDGG 692
                                   ...:||:    ||..|||         |....:|:||.|
Zfish   236 -----------------------FGVISRSSFTRDSKDSKD---------SRECEHENGYSS--- 265

  Fly   693 ATGARLGNNLSISGGDTESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPST---RNSSICSA 754
             ..|.:.:..|.|..||.:..|.....:.|:           |...:.:|:.:|   |:.|..|.
Zfish   266 -MEAEVTSPESSSPQDTPTDDSPITGPSELM-----------MSNHMRVGSTATLPCRSRSRMSE 318

  Fly   755 PVSLGGYNYDYETETI--------RRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIV 811
                     :::||:|        |...|..|:.....:|.:||.:   |....|....:..::.
Zfish   319 ---------NFKTESISSEPSGQPREGGRIWKMHMVKGQDGLGIQI---TGGRGSKRSPHGIIVA 371

  Fly   812 ELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFY 876
            .:|..|..|:||||:.|||::.:||..|.|: |..|...:|.| ....:.||:|..:.:.| ||:
Zfish   372 HVEEGGATQRDGRLKAGDELLMINGHSLVGL-SHQEAVAILRS-TAGLVQLVVASRDESEV-DFH 433

  Fly   877 TKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASV 941
            .                ...|...|.:|:........      :..:|:|....|..|.|  ||.
Zfish   434 K----------------YPSTSLPDLVSTCSGPDASP------SPGEEKENMEPDMEDVR--ASS 474

  Fly   942 STMPTPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPL-FASGSSSCSSSP 1005
            .::||.                |: ..:|:.|..|.| ..|.:....:|||: |.|.|....|
Zfish   475 LSLPTQ----------------DL-FTDHDRLDERGR-IEGPKGCCRSPTPMKFRSRSQGGGS-- 519

  Fly  1006 NHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFG 1070
              ||                            .|:.:|::   |..:....||.::..|..   |
Zfish   520 --RL----------------------------ESVGEDDE---LIVENGDTGSDVAEKPTR---G 548

  Fly  1071 QRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTN 1135
            .|.|                                ..|....|||                 ..
Zfish   549 GRKH--------------------------------SLPQQLDTVG-----------------IR 564

  Fly  1136 QQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPS 1200
            |:.|           .:|.|.:|:|
Zfish   565 QEYQ-----------IVKKSARSLS---------------------------------------- 578

  Fly  1201 LPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKT 1265
                  |::.|....:.:.|:.        ..|...||.| |.||||||||:||.:|.|||||||
Zfish   579 ------TVQVESPWRLAQPSII--------SNIVLMKGQG-KGLGFSIVGGQDSARGRMGIFVKT 628

  Fly  1266 VFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKLQKAKSMGC 1329
            :||:|.||.||.|:.||||:|:||.|:||::|.:.|..||.:::|.:.|.: |.:|:......|
Zfish   629 IFPNGAAAADGRLKEGDEILEVNGESLQGLTHQQAIQTFKQLKKGVVTLTV-RTRLRSPSLTPC 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	27/89 (30%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	47/86 (55%)
pdzd2	XP_003198698.3	PDZ_signaling	346..423	CDD:238492	25/81 (31%)
		PDZ_signaling	597..680	CDD:238492	47/84 (56%)
		PDZ_signaling	733..817	CDD:238492
		PDZ_signaling	1185..1268	CDD:238492
		NRIP1_repr_1	1556..>1766	CDD:292315
		PDZ_signaling	2216..2288	CDD:238492
		PDZ_signaling	2345..2427	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24215
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000