DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and grip2a

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_017212845.1	Gene:	grip2a / 568084	ZFINID:	ZDB-GENE-081104-132	Length:	1100	Species:	Danio rerio

Alignment Length:	785	Identity:	174/785 - (22%)
Similarity:	278/785 - (35%)	Gaps:	193/785 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 KDWEPLYQRLSSCLSSNESGY-------DSDGGAT--------GARLGNNLSISGG-DTESIAS- 714
            ||..| |.:.|...:|:.||:       |...|.|        |:.||  |:|||| |.|....
Zfish    55 KDDVP-YTKGSKDTASDSSGFTNRCSLADEQRGVTTVELIKKEGSSLG--LTISGGCDKEGKPRV 116

  Fly   715 GTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGG---YNYDYE---------- 766
            ..|:...|.:.|....||..:....|:.....|:..|.|...::|.   ...:||
Zfish   117 SNLRPGGLAARSDQLNVGDYIKSVNGINLSKLRHDEIISMLKNIGERVVLEVEYELPPFAPSNPC 181

  Fly   767 ---TETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVE-LEPYGMAQKDGRLRL 827
               ::||     :|.||:  :.:..|.||...   .:.:..:.|.|:|. :.|.|.|.::|.||.
Zfish   182 SVISKTI-----EVCLEK--EGNSFGFVLRGG---FHEDWHKARPLVVTYVRPGGPADREGTLRA 236

  Fly   828 GDEIVNVNG------KHLRGI----QSFAE--------------VQR------------------ 850
            ||.:::|||      ||...:    ||..|              ||:
Zfish   237 GDRVLSVNGVAVNRQKHADALTLIMQSSQEAFFLIEYDIMVMDSVQKSSGPLQVDIARSAGSVLG 301

  Fly   851 --LLSSFVDNCIDLVIAHDEVTTVTDFYTKIR-------IDGMSTQRHRLSYVQRTQSTDS---- 902
              |.:|...|...:.|...:..:|.|....:.       ||||||:...|...|:..|:.|
Zfish   302 LSLSTSLYRNKQVITIQKIKPASVADRCGALHAGDILLAIDGMSTEHCSLMEAQQLLSSSSELTK 366

  Fly   903 LSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDA----RSMASVSTMPTPMPLMQHR-------RS 956
            |..:.||...|:.::...:.|.|....|:..:|    :...|..:..||.|  .||       .:
Zfish   367 LEILPSLHSSQDTVRVQRSCQRQWDSSENYTNALPAFQKTPSAWSQTTPTP--SHRSVSSGVSAN 429

  Fly   957 STPRHSLDVG-------------------APEHELLRRRARSSSGQRSLALTPTPLFASGSSSCS 1002
            ::..||.:.|                   :|.....:||.|....:.||:|..:.:.|.|.....
Zfish   430 TSGFHSYNCGSQSAYPNTYPSSTLPSYPSSPRCSATKRRHRRKEHKSSLSLASSTVGAGGQVVHL 494

  Fly  1003 SSPNHRLLDNENDPAN--DTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCS----EGSALS 1061
            .|....|   ..||..  .......|:|....|...|....:.:    ...:||.    ....||
Zfish   495 ESAEVLL---RGDPLTGFGLQLQGGVFATEPLSAPAAIRFIEPD----TPAERCGVLQVGDRILS 552

  Fly  1062 ATPNPQQFG--QRTHYARNSINLANSHYRSLRF--AHSRLSSSRLSLFMQAPPNSLTVGEGVANT 1122
            ....|.:.|  :..:.......|||.....:.|  |.|.:.||  ..|....|....|..|:..:
Zfish   553 INGIPTEDGTLEEANQLLRDAALANKIALEVEFDVAESVIPSS--GTFQVKLPKRRGVELGITIS 615

  Fly  1123 PSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSL 1187
            .|..|.....::..|:..           |.|   .:....|...:.|..:....:...
Zfish   616 ASKKAGKPLIISEIQKGS-----------IAH---RIGTLEPGDRLLAIDNVRLDNCGM------ 660

  Fly  1188 APPAAALMHHRPSLPVAKLTI-RDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGG 1251
               ..|:|..:.:..:.||.| :||:..:.:.:|   ||...|.: :....||    ||.:|.|.
Zfish   661 ---EEAMMVLQQAEGMVKLRIQKDEDNLDELESS---GSVIFTVE-LKRHGGP----LGITISGT 714

  Fly  1252 RD--SPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVL 1314
            .:  :|     |.:.::..:|.|...|.|..||.::.||..|::|...:|.|.|.:...: |:.|
Zfish   715 EEPFNP-----ILISSLTRNGLAHRTGALHIGDRVLAINNMSLKGKPLSEAIHLLQTAGD-TVTL 773

  Fly  1315 KILRR 1319
            ||.:|
Zfish   774 KIKKR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	30/134 (22%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	24/88 (27%)
grip2a	XP_017212845.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900