Protein Alignment a and LOC5667987

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_061511687.1
• Gene: LOC5667987 / 5667987
• VectorBaseID: AGAMI1_011808
• Length: 1215
• Species: Anopheles gambiae
• Alignment Length: 1527
• Identity: 446/1527 - (29%)
• Similarity: 618/1527 - (40%)
• Gaps: 517/1527 - (33%)

  Fly     1 MRLFKTRKSTDTYSTLAAQQQQQQQQQQQHQAEGSNISHSSNSSSNKSHTPATCSNRLNKSIVS- 64
            |||||.:|..:....|               |.||:.|.|:.:.|......|:..|.:....||
Mosquito     1 MRLFKAKKLLEGPQVL---------------ARGSSASPSAPALSPIEPVNASAYNDILVLPVSA 50

  Fly    65 ---STSISSSLPDLHDKSPVMILSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQ 126
               ::...|.||.|..:...:|..|.:.|          |:.|...|..:.||.|      |...
Mosquito    51 APANSKFDSELPSLLSEVVEVISGCNSPA----------TSVADTPAPDAPGSGQ------LDTP 99

  Fly   127 QQQQPLRTATPTCLLSGRQTPSAISVMSLQEATSLH-----------RQQQQPHQPPTIYVPVPT 180
            ...|.|..|.|...::...|.:..|:.:...|.|.|           |.|::|.      .|.||
Mosquito   100 DCNQTLPPADPMAPVASMATDNVCSINNASSAESPHVRNQGVEARLMRDQRRPR------TPSPT 158

  Fly   181 KLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASGG 245
            ..|.:   |..:||:                                           |.|..
Mosquito   159 GTGQH---GQPTATI-------------------------------------------GRNGI-- 175

  Fly   246 ASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSLPATEASRNSNSSSNMNGSSNSNSLDV 310
                         |.|..:::|||:|.:||:||   ..||.|
Mosquito   176 -------------GTLAGFRMVTAVPALVLEDE---PPLPRT----------------------- 201

  Fly   311 SNSNSHSGSSTSLASTTRNVFTWGKRMSRKLDLLKR-SDSPAAAHKSHSDLRSLFHSPTHHKSGS 374
                         |..::||||||::|.:|.|||:| ||:                    ||...
Mosquito   202 -------------AKESKNVFTWGRKMGKKFDLLRRGSDA--------------------HKLAV 233

  Fly   375 GGSSG------------PSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQ 427
            .||..            .:|:..|.||...   ::.|..|:.:.|    |.||....|:..::.:
Mosquito   234 PGSVALVTVAPPVVPPPATSSTFSMSPISA---AATSIASSSEPC----ISTICGADQESGRKGK 291

  Fly   428 SVQDVGTGQS-QSAQSTPTHQFQ------AAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAA 485
            |...:...|| :||...|.....      .:.|.....:|||:|:||||||||:|:...|.....
Mosquito   292 STVPLKAHQSHRSANGGPATNGHDPLVKLNSERSSGTFRNFFYRMGSTGMLNHKSNQYQKQQFLQ 356

  Fly   486 QQATP------------------AAT-----------TLYRSSSTSQLSSSSYVKCDDPTEGLNL 521
            ||.|.                  |.|           .||||||||||::||||||||||:|:||
Mosquito   357 QQQTQLQAQHSQQPHQLLHHMSLAQTQADLSKIEHQQMLYRSSSTSQLNTSSYVKCDDPTDGVNL 421

  Fly   522 QREQREQRLPRIAS-------------------------------------LKSSSCDDIAKVSS 549
            .....:..:...:|                                     .|||||||||:|..
Mosquito   422 ANGHTKSSVGSSSSSSQLHLTGLRGEQTNGAAGNGASNSETSSASPSSSTATKSSSCDDIARVGQ 486

  Fly   550 CLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPG 614
            ..|.|      .|||                      |::..||||||||:||||||||.|:|..
Mosquito   487 QTTPS------EGSL----------------------SKKNHFPYAFLRSKLSVLPEENGGSVIN 523

  Fly   615 H--LKQQIQR--QREQHQQHQRDLLQQEQTSSP------------LPQRRSPEQAMLNN----VS 659
            :  :|:.:.|  .|......:.||.....|.|.            ||.....:....|:    :|
Mosquito   524 YSRIKENLLRTGNRGSIVSLRSDLDSVSITDSQLNISGESGSDVFLPSATDSKSIGANSDVGIMS 588

  Fly   660 RNDSI-TSKDWEPL----YQRLSSCLSSNESGYDSDG--------GATGARLGNNLSIS------ 705
            ||:|| |..|.|..    |||||||||||||||||||        .|:...|.:::|:|
Mosquito   589 RNNSIKTLTDTEHSFVLNYQRLSSCLSSNESGYDSDGRHAEDKIDDASNTSLSSSVSLSHHHHQQ 653

  Fly   706 -----------GGDT---------ESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSS 750
                       |||.         :|...|:.:|     ||||                   :||
Mosquito   654 QQQQLSGASFNGGDAYVDAIRSKDQSYVFGSRRR-----LSSS-------------------SSS 694

  Fly   751 ICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEP 815
            |.|...:..|   .::..||||||||:||.::..:|.|||.|:|:|:..:..|.:.|||:.|::|
Mosquito   695 IVSGVAATNG---GFDCGTIRRRFRQIKLVKQQGDDTIGIELTPQTIGLDEGECETRYLVTEIDP 756

  Fly   816 YGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTV-TDFYTKI 879
            .|:|.||||||:|||||||||.||||:||.:.|||:||:||:|.:||||||||:||. :|...||
Mosquito   757 EGIAYKDGRLRIGDEIVNVNGHHLRGLQSPSTVQRILSTFVNNVVDLVIAHDELTTFNSDANRKI 821

  Fly   880 RIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTM 944
            :||........:: :..:.|:...||                               |.:|.|:.
Mosquito   822 KIDSRPATSGAIT-IGGSSSSSGASS-------------------------------SSSSSSSS 854

  Fly   945 PTPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASG-SSSCSSSPNHR 1008
            ||                               |||.|.   |:|.||...:| :.....:|.:.
Mosquito   855 PT-------------------------------RSSKGP---AVTSTPSNTAGPAKPFPLTPIYA 885

  Fly  1009 LLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCS-----------------E 1056
                   ||:    |.||||||   :.:::::.||||||:::::||.                 :
Mosquito   886 -------PAD----YVPVYANR---ISISNTICDDEKWQMISKQRCEALVKNGYSQILGSKRLIK 936

  Fly  1057 GSALSATPNPQQFGQRTH---------------YARNSINLANSHYRSLRFAHSRLSSSRLSLFM 1106
            .|.....||....||..|               .:..|||.:..|..:...|....:|||.|:..
Mosquito   937 DSDEELLPNGGDHGQPKHRIDSNETGLYSLYRPVSHGSINQSIRHLTANGEADDGNASSRASIAE 1001

  Fly  1107 QAPPNSL--TVGEGV-ANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYV 1168
            ...|..|  .:.:.: .|.|..:|.........::.            |..|.:.:.|.|.:..|
Mosquito  1002 GHAPTVLVQVISDTIRRNVPIGSAYRGAKALKSEED------------IPRSVQRIRLKSDDGVV 1054

  Fly  1169 NA---SSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTP 1230
            .:   :|.|...|.:....|.........:.........::.|.:|      .:|..||..:||.
Mosquito  1055 ESKAEASVPLQRSKTESNVSGARDELDCTLDGTKFEAGVRILINEE------GSSYIEGIHKCTY 1113

  Fly  1231 KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGM 1295
            .|:||:||.|:||||||||||||||:|||||:|||||||||||.||||.|||||:.||..:||||
Mosquito  1114 LTVTFYKGTGMKSLGFSIVGGRDSPRGNMGIYVKTVFPSGQAALDGTLMAGDEILSINDAAVQGM 1178

  Fly  1296 SHAETIGLFKNVREGTIVLKILRRKLQKAKSM 1327
            ||.|||.|||||:||.:|||:.||:..:|||:
Mosquito  1179 SHCETIALFKNVKEGPVVLKLARRRYHRAKSV 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	38/52 (73%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	65/84 (77%)
LOC5667987	XP_061511687.1	None