DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and lnx2b

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	953	Identity:	170/953 - (17%)
Similarity:	276/953 - (28%)	Gaps:	438/953 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 TLKKCKSGP-----IETIKQRHQQQQQQQQ--------SVQDVGTGQSQSAQST-PTHQFQAAAR 453
            ::::|:..|     ....|:..::.:::::        |..|.....::|||:. .|.|..|.:.
Zfish   119 SMQRCELQPHLHNRCPAFKRLREEAERKKRPSWNELKGSKSDGDLADAKSAQTIGRTAQLSAPSE 183

  Fly   454 PQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEG 518
            |              |::|       .|.|..:..||...:|...::..:|..      :||.|.
Zfish   184 P--------------GLVN-------PAFEEGEDDTPLRCSLVAEATVVELFR------EDPGED 221

  Fly   519 LNL---------------QREQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSGSAAGSLGSPP 568
            |.|               |...|:..:.|...|...  |.|.:|:....||.|...|...:..|.
Zfish   222 LGLRIVGGKDTPLGNIVIQEIVRDSLVARDGKLAPG--DHILEVNDVSLASISHSRAIAVIRQPC 284

  Fly   569 SSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQRD 633
            |                            |.||:|:.|:.....|.|           |.|
Zfish   285 S----------------------------RLRLTVMQEKGFKPRPEH-----------HTQ---- 306

  Fly   634 LLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARL 698
                   .|..|..:||                              |:|::
Zfish   307 -------PSASPPTQSP------------------------------STNQN------------- 321

  Fly   699 GNNLSISGGDTESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNY 763
                           .||:.:.:|:....||.:|
Zfish   322 ---------------HGTVIQVTLVKHERSEALG------------------------------- 340

  Fly   764 DYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLG 828
                         :||.||.:|..:                    .|::|.|.|:|.|||:||..
Zfish   341 -------------IKLIRKSEEPGV--------------------FILDLLPGGLAAKDGKLRNN 372

  Fly   829 DEIVNVNGKHLR-GI-QSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRL 891
            |:::.:||:.|| |. :|.|::                                   :.....|:
Zfish   373 DKVLGINGQDLRHGTPESAAQI-----------------------------------IQASEMRV 402

  Fly   892 SYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRS 956
            ::|             .::||....:|          ||.|  :|....|   |.|    |:.|
Zfish   403 NFV-------------VMRLQDVSEEG----------GEGQ--SRGARRV---PEP----QYFR- 434

  Fly   957 STPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTP-----LFASGSSSCSSSPNHRLLDNENDP 1016
               |||..:..|.       ...||.::::.|...|     :..:|...|.|    ||
Zfish   435 ---RHSEYMKEPP-------GGFSSQEKTVTLKKEPRQSLGITIAGGRDCRS----RL------- 478

  Fly  1017 ANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSIN 1081
                    |||   ..||.....|..|        .....|..|.:.              |.|:
Zfish   479 --------PVY---ITSVQPVGCLHRD--------GTVKTGDVLLSI--------------NGID 510

  Fly  1082 LANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQT 1146
            |.:                            ||..|.|....:.||.:|..|...|....:::|.
Zfish   511 LTH----------------------------LTYNEAVTVLKTQTAQSTVTLRVIQTFADDEEQD 547

  Fly  1147 HQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDE 1211
            .:                      |.|.....|..|.                         :|:
Zfish   548 GE----------------------SGSREDMDTMEGP-------------------------KDD 565

  Fly  1212 EMAEVIRASMSEGSGRCTP--KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAAD 1274
            ::..|...:...|...|..  :.|...| ...:|.|||||||.:..:|....|:||:.|...|..
Zfish   566 DINWVPLWTRWLGLPSCIHWCRDIMLMK-TNSESWGFSIVGGYEESRGQQPFFIKTIVPGTPAYF 629

  Fly  1275 DGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            ||.|:.|||||.:||.:..||:::..|.:.| :::..:.|.::
Zfish   630 DGRLKCGDEIVAVNGVTTVGMNNSSLIPMLK-LQKNKVTLTVV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	23/91 (25%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	31/88 (35%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492	22/116 (19%)
		PDZ_signaling	325..406	CDD:238492	29/192 (15%)
		PDZ_signaling	451..537	CDD:238492	27/157 (17%)
		PDZ_signaling	587..671	CDD:238492	31/85 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000