DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and lnx1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	777	Identity:	165/777 - (21%)
Similarity:	265/777 - (34%)	Gaps:	206/777 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 VLPEENHGNVPGHLK----------QQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNN 657
            |:|   .|.:.||::          ...:|:|...:....| ...|.|.:.||....|..| :..
Zfish   130 VMP---RGEMEGHIRCRCKGASHYGLSAERKRRSQEGDCTD-STSELTLAALPGEGCPSSA-IAL 189

  Fly   658 VSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLS-ISGGDTESIASGTLKR-N 720
            :|....:.:..:||      |...:::||..:   :..||.|:..| ....|..|:.|.:.:| |
Zfish   190 LSDEPGLVNPAYEP------SVEDNSQSGSTT---SLAARSGSRKSEYRNFDRTSVRSRSFRRLN 245

  Fly   721 SLISLSSSEGVGMGMGMSLGLGAPSTRNSSICS-----APVSLGGYNYDYETETIRRRFRQVKLE 780
            ...|:......|..:.........:.||::|.:     |...|.....|.|..:|       |:.
Zfish   246 RAFSVLRRTKSGTAVANDTTEERDNLRNANIPAEGELFALPQLHHLIPDGEVTSI-------KIT 303

  Fly   781 R--KCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQ 843
            |  .|:...|.||...:|.:.       |.||.::...|:..:||||..||.|:.|||..:
Zfish   304 RADPCEPLAISIVGGNETPLV-------RILIQDIYREGVIARDGRLLPGDMILKVNGIDI---- 357

  Fly   844 SFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRL---------SYVQRTQS 899
                      |.|.:|.       .|..:....|.:|:..:..||||.         ::...|.:
Zfish   358 ----------SNVPHCY-------AVAALKQPCTLLRLTVLREQRHRYRSHHHSPTEAFPAHTAT 405

  Fly   900 --TDSLSSMQSLQLQQERIQGHNTEQEQE---------------AQGEDQCDARSMASVSTMPTP 947
              .|||..:...:...|::......:..|               ..|..:.|.|.:|
Zfish   406 IRDDSLHVVLVKRAPDEQLGIKLVRRPDEHGVFIFHLLEGGLAARDGRLRVDDRVLA-------- 462

  Fly   948 MPLMQHRRSSTPRHSLDVGAPEHELLRRRARSS------SGQRSLALTPTP-LFASGSSSCSSSP 1005
                      ...|.|..|||||..|..:|...      |.|..:   |.| :......:....|
Zfish   463 ----------INGHDLRYGAPEHAALLIQASEDRVHFIVSRQTHI---PAPDILQEAPWNMEGPP 514

  Fly  1006 -------NHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSAT 1063
                   .|.|||:...||                 |...::.      ||.....|.|..::..
Zfish   515 PYSPVDIEHTLLDSCQKPA-----------------CYEKTVT------LLKEPHDSLGMTVAGG 556

  Fly  1064 PNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTAT 1128
            .:.:.:....:......|.......|:|.....|:.:.:.|      ..:|..|.|||..::::.
Zfish   557 MSSRGWDLPVYVTNVDPNGVVGQEGSIRKGDILLNVNGVDL------TGVTRSEAVANLKNTSSP 615

  Fly  1129 TTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPP--- 1190
            ....:...:...::.......|   |||.::|          .|||...        .|.||
Zfish   616 VVLQVLEMRPPNESSLDCMPPL---HSPCALS----------PSSPGDV--------KLPPPNDD 659

  Fly  1191 AAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSP 1255
            .|.|......||......:|    .|:|.|.|                   .|||||||||::..
Zfish   660 YAPLWVSWLQLPRHLYCCKD----IVLRRSTS-------------------GSLGFSIVGGQEEL 701

  Fly  1256 KGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            ..|...|::::.....|.:||.::.||.::|:||.|..||:|...:.|.|.:| |.|.|.|:
Zfish   702 NCNQSFFIRSIVEGTPAYNDGRIRCGDILLEVNGKSTWGMTHTALVRLLKELR-GRITLTIV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	24/91 (26%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	29/86 (34%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492	28/118 (24%)
		PDZ_signaling	411..491	CDD:238492	16/97 (16%)
		PDZ_signaling	536..621	CDD:238492	14/96 (15%)
		DegQ	<548..621	CDD:223343	12/78 (15%)
		PDZ_signaling	678..762	CDD:238492	34/107 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000