Protein Alignment a and si:dkey-92j12.5

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_068077317.2
• Gene: si:dkey-92j12.5 / 560912
• ZFINID: ZDB-GENE-090313-354
• Length: 1894
• Species: Danio rerio
• Alignment Length: 1448
• Identity: 285/1448 - (19%)
• Similarity: 455/1448 - (31%)
• Gaps: 497/1448 - (34%)

  Fly    29 QHQAEGSNISHSSNSSSNKSHT-----PATCSNRLNKSIVSSTSISSSLPDLHDKSPVMILSCTT 88
            :|..:.|....:|:|..:|...     |::...|....:..::|:..::..|.|.|.::|.|
Zfish   784 EHNHQHSTFQTNSHSQKSKMEAEPVSIPSSGYERTITVVRGNSSLGMTVSALRDGSGIIIRS--- 845

  Fly    89 LASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQQQQQPLRTAT---PTCLLSGRQTPSAI 150
            :...|:.:.....|...|..|.:|     :...:|.:.|.:..||..:   |.  ||....|:|.
Zfish   846 VVHGGSISKDGRLAVGDGIVALNG-----ESTTNLTNAQARAMLRRHSLIGPD--LSVMYVPAAF 903

  Fly   151 SVMSLQEAT-SLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQ 214
              :.|..|: |..:::.:.|.|..:                                     |.:
Zfish   904 --LDLHRASYSKSKEEMEIHTPAAV-------------------------------------QHR 929

  Fly   215 HAAQYQQYVAQRLHAASSSCLYEKGSNASGGASSNKSSLSLTPNGHLPDYKLVTAMPVVV-LD-D 277
            |        :|.|......|:.|:.|...|...:.|:... ..|..:.::..:....:.. || |
Zfish   930 H--------SQNLPFKPLECISEQQSVVDGKGVNGKTQAE-EENERIDEHSPIKQREISKRLDRD 985

  Fly   278 EHKSNSLPATEASRNSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTR-------------N 329
            :...|..||.:       |.|.:..............:|....||.....|             :
Zfish   986 QKVKNEKPALQ-------SENRHEQEREKDRQRDEKETHGRDHTSWTQPRRVKLSRAGGTCLGFS 1043

  Fly   330 VF---TWGKRMS----RKLDLLKR--SDSPAAAHKSH---------------SDLRSLFHSPTHH 370
            ||   ..|.|:|    |:...:|.  .||| |||.|.               ||.       ||.
Zfish  1044 VFGGRGMGSRLSNGEMRRGIFIKHIAEDSP-AAHNSTLKEGDRILQVQGIDVSDF-------THE 1100

  Fly   371 KSGSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQD-VGT 434
            ::            ..|....|.:                 :|.:.|..|..:.......| :..
Zfish  1101 EA------------VEAIRRAGDR-----------------VELLVQSPQFSEPDNYLEDDRISK 1136

  Fly   435 GQSQSAQS-------TPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAA 492
            ..||::|.       :||..|...  |.|..:::     ..|...|.:.:|||
Zfish  1137 TNSQNSQESEIPNNLSPTFPFSPI--PFKRTEDW-----KLGKPPHSAPSLLK------------ 1182

  Fly   493 TTLYRSSSTSQLSSSSYVKC---DDPTEGLNLQREQREQRLPRIASLKSSSCDDIA---KVSSCL 551
                             :.|   :..|:|:        ||||....|...:..|.:   :.|...
Zfish  1183 -----------------LPCRPDETQTDGV--------QRLPERPPLPEETSHDHSGQEQTSYWS 1222

  Fly   552 TASTSSGSAAGSL--GSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEE------- 607
            ......||..|.|  .....|:...|.|...||..|    ||      |.|:||...|
Zfish  1223 RMQQRYGSLPGELLMFDLDCSSHGSGLGLCLSGNRD----GA------RGRMSVFVSEITADGAA 1277

  Fly   608 -NHGNV-PGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNN--------VSRND 662
             ..|.| .|....:|..|....:.||.                  ..|::||        ::||.
Zfish  1278 AADGRVRVGDELLEINGQVLYGRSHQN------------------ATAIINNAPAKVRILLTRNK 1324

  Fly   663 SITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISGGDTESIAS--GTLKRNSLISL 725
            ::..:......:.:.||.....|.:              :.:...|..|:.|  |.:.|...:..
Zfish  1325 AVQKQMTSGPEKEMDSCPEIYPSVH--------------IDMIAEDQHSVLSQDGRITREDKLKS 1375

  Fly   726 SSSEGVGMGMGMSLGLGAPSTRNS--------------SICSAPVSLGGYNYDYETETIRRRFRQ 776
            .|||      .:::||.||....|              |.|..|.|.|..:.|..|.....|...
Zfish  1376 RSSE------SLNVGLPAPINATSNHQASCHPASQTPISRCIPPQSSGISSADESTANQSSRIWP 1434

  Fly   777 VKLERKCQ----EDYIGIVLSPKTVMT----------------NSNEQQYRYLIVELEPYGMAQK 821
            .....:.|    .|.:...:.|..:.|                ..|......:|.|:...|.|.:
Zfish  1435 HSTSHRAQCSVSSDPLTCPIIPGCINTVDICKGTTGLGLSIVGGCNTLLGVIVIHEVNKDGAAHR 1499

  Fly   822 DGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIA-HDEVTTVTDFYTKIRIDGMS 885
            ||||..||.|:.|||                       |||.:| |:|..:|      :|   :|
Zfish  1500 DGRLWAGDHILEVNG-----------------------IDLRMATHEEALSV------LR---LS 1532

  Fly   886 TQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPL 950
            .||.||| :.|...|:.                |:....|:...||..|               |
Zfish  1533 PQRVRLS-IYRDHVTEK----------------HSKHTSQKHTPEDMWD---------------L 1565

  Fly   951 MQHRRSSTPRHSL---------DVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPN 1006
            .....:..||..|         |.|....|:.|..|....|:  |.|....|..:|....::|.:
Zfish  1566 FNVELNLQPRQGLGLCIVGKMNDTGIFVSEITRGGAADVDGR--LLLGDQILSVNGEDIRAASQD 1628

  Fly  1007 HRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQ 1071
            |                             ||:|.          :||| ||.|...   .:|..
Zfish  1629 H-----------------------------ASALL----------QRCS-GSVLLEV---ARFKA 1650

  Fly  1072 RTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGV-ANTPSSTATTTTDLTN 1135
            .:||:..                .::....:.||     :.|...:.| .|....|.|......:
Zfish  1651 SSHYSYG----------------DQVGEVDVPLF-----SCLNTHDSVDGNVDIRTVTVQKHECD 1694

  Fly  1136 QQQQQQNQQQTHQSLYIKHSPKSV------------SLFSPNPYVNASSSPASAS----TSAGA- 1183
            ..:.:......|..:||.....|.            .:.|.|.......|.|.||    .|:||
Zfish  1695 SVELRVRDTLGHAGMYISELDASTLAARSGLLQLGSRVISINGTQTERLSVAEASFLLKNSSGAV 1759

  Fly  1184 -----------GSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFK 1237
                       |:|::...::|:|..|.|.....|...:...:.              :|||..:
Zfish  1760 TLQVMPSGCADGASISTDRSSLIHSSPGLSENYTTHNHQSSPQY--------------QTITLER 1810

  Fly  1238 GPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIG 1302
            |..  .||||||||..|..|::.|:||.:||.|.|.:||.|:.||:::.:||.|::|::|:|.:.
Zfish  1811 GSA--GLGFSIVGGFGSSHGDLPIYVKNIFPKGAAVEDGRLRRGDQLLTVNGQSLEGVTHSEAVE 1873

  Fly  1303 LFKNVREGTIVLKILRRK 1320
            :.:.. .||::|::|.::
Zfish  1874 ILRQT-SGTVILQVLSKR 1890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	17/53 (32%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	35/84 (42%)
si:dkey-92j12.5	XP_068077317.2	None