DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and grip1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	860	Identity:	168/860 - (19%)
Similarity:	301/860 - (35%)	Gaps:	234/860 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 PEENHGNVPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAM-LNNVSRNDSITSKD 668
            |||::..  |:  :.:.....:|..|:....:....|.|      |:.|: :...|..|......
Zfish    24 PEEDYHE--GY--EDVYYYASEHLHHEGPYTKHSNPSRP------PDGALAIRRQSIPDEFKGTS 78

  Fly   669 WEPLYQRLSSCLSSNES-GYDSDG---------GATGARLGNNLSISGGDTESIASG----TLKR 719
            ...|.::..:.|....| |.|.||         |...|| .:.|::  ||.....:|    ..:.
Zfish    79 TVELIKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAAR-SDQLNV--GDYIKSVNGINLTKFRH 140

  Fly   720 NSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQ 784
            :.:|||..:.|..:.:.:...|...|.:.|.:                     .|:.|::....:
Zfish   141 DEIISLLKNVGERVVLEVEYELPPVSVQGSGV---------------------MFKNVEVTLHKE 184

  Fly   785 EDYIGIVL-----------SPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKH 838
            .:..|.|:           .|.|:.|             :.|.|.|.::|.::.||.:::::|..
Zfish   185 GNTFGFVIRGGAHEDRNKSRPVTITT-------------IRPGGPADREGTIKPGDRLLSIDGIR 236

  Fly   839 LRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDS- 902
            |.| .|.||...:|..          ...|.|.:.::...: :|.::|....| .|:..:|..|
Zfish   237 LHG-ASHAEAMSILKQ----------CGQEATLLIEYDVSV-MDSVATASGPL-LVEVAKSMGSS 288

  Fly   903 --LSSMQSLQLQQERIQGHNTEQEQEAQGEDQC------------DARSMASVSTMPTPMPLM-- 951
              |:...|:...::.|   ..::.:.|...|:|            |..|| ...|:.....|:
Zfish   289 LGLALSTSMYCNKQVI---IIDKVKPASIADRCGALHAGDHILSVDGTSM-EYCTLAEATQLLAS 349

  Fly   952 --QH-RRSSTPRHS--LDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCS--------- 1002
              :| :....|.|.  |.:..|||..::|..|           |.| :.||:::.|
Zfish   350 ASEHVKMEILPHHQTRLALKGPEHVKVQRSTR-----------PLP-WESGTNNNSNFLPYQHYN 402

  Fly  1003 ------SSPNHRLLDNENDPANDTDSYTPVYANRAASVCV----ASSLADDEKWQLLAR---KRC 1054
                  |....:.....|.|...:.|.|.:.|...:|:.:    .:......:..::.|   |:.
Zfish   403 TYHPDQSHSQAKKTSPSNPPLGSSFSPTSMSAYSLSSLNMNTLPRTMYPTSPRGTMMRRKLKKKD 467

  Fly  1055 SEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLR-------FAHSRLSSSRLSLFMQAPPNS 1112
            .:.|...|:......||..|.....:.|.:.......       ||...|||..|..::.  |:|
Zfish   468 YKSSMSLASSTVGLAGQVVHTETTEVTLISDSIMGFGIQLQGGVFATETLSSPPLIAYID--PDS 530

  Fly  1113 -------LTVGEGVANTPS-STATTTTDLTNQQQQQQNQQQTHQSLYIKHS-PKSVSLFSPNPYV 1168
                   |.:|:.:.:... .|..:|.:.|| |..:.:...:..:|.|:.. .:||...|...:|
Zfish   531 PAERCGILQIGDRILSINGIPTEDSTLEETN-QLLRDSSITSKVTLEIEFDVAESVIPSSGTFHV 594

  Fly  1169 NASSSPA-------SASTSAGAGSSLA---PPAAALMHHRPSL---------------------- 1201
            .....|.       |:.:|...|.:|.   ....::.|...:|
Zfish   595 KLPKKPGVELGITISSPSSRKPGDALIISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDA 659

  Fly  1202 --------PVAKLTIR-DEEMAEVIRASMSEGSGR----C------TPKTITF------FKGPGL 1241
                    .:.||.|| ||:.:.|:||...:.:.|    |      |...|.:      :.||
Zfish   660 VQILQQCEDLVKLKIRKDEDNSGVLRAGSVDRNARVLLACVADEQETSGAIIYTVELKRYGGP-- 722

  Fly  1242 KSLGFSIVGGRD--SPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLF 1304
              ||.:|.|..:  .|     |.:.::...|.|...|.:..||.|:.||.||::|...:|.|.|.
Zfish   723 --LGITISGTEEPFDP-----IIISSLTKGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLL 780

  Fly  1305 KNVREGTIVLKILRR 1319
            :...| ::.|||.::
Zfish   781 QMAGE-SVTLKIKKQ 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	19/100 (19%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	26/94 (28%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	18/82 (22%)
		PDZ_signaling	178..261	CDD:238492	20/106 (19%)
		PDZ_signaling	276..359	CDD:238492	16/87 (18%)
		PDZ_signaling	490..578	CDD:238492	17/90 (19%)
		PDZ_signaling	591..675	CDD:238492	10/83 (12%)
		PDZ_signaling	711..792	CDD:238492	25/90 (28%)
		PDZ_signaling	1053..1133	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810