DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and ssp6

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	211/1056 - (19%)
Similarity:	322/1056 - (30%)	Gaps:	407/1056 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SPVMILSC---TTLASNGATATAAVTATATGTAATSGGSL----------------QQQQQQHLQ 124
            |..|..||   .|.||:.||..|||:.:|:.  |||.|||                .|.|||||.
  Fly     3 SKPMSTSCQSIATAASSAATTAAAVSISASN--ATSVGSLIAAACQQEQPHPHQHYSQSQQQHLY 65

  Fly   125 HQQQQQPLRTATPTCLLSGR--------QTPSAISVMSLQEATSL---HRQQQQPHQPP------ 172
            ||..||.......|..| ||        .:...|....|..:|.:   |:.::.....|
  Fly    66 HQSHQQASHYVNGTGSL-GRLKFHKSLDASDEEIEYAQLSRSTHILGRHKSERYLASNPDEDRRR 129

  Fly   173 -TIYVPVPTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLY 236
             ||.|.         ...||....|.|||     .:.::.::.....|..||
  Fly   130 RTIIVE---------KKNNSYGFTLQSYG-----IHYKRDEELEMITYVDYV------------- 167

  Fly   237 EKGSNASGGASSNKSSLSLTPNG---HLPDYKLV--------TAMPVVV---------------- 274
            |.|..|. .|...:..:.|:.||   ...|:|.:        |.|.:||
  Fly   168 EYGGPAY-RAGMREGDVILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYI 231

  Fly   275 -----------------------LDDEHKSNSLPATEASRNSNSSSNMNGSSNSNSLDVSNSNSH 316
                                   |:.:.|::||||.:.: |:|:|     .|:...:..:.....
  Fly   232 QLQSMLQQKMNELERVHLRERELLEGKWKTHSLPARKKA-NANTS-----PSDGEGVSPTEVAGE 290

  Fly   317 SGSSTSLASTTRNVFTWGKRMSRKLDLLKRSDSPAAAHKSH-----------SDLRSLFH----- 365
            :|......||                    .|.|..|.:.|           :.....:|
  Fly   291 AGFYRPALST--------------------EDVPNIAARQHGVGGPGIIPPPAQFMLTYHYLDPT 335

  Fly   366 -----SPTHHKS-----GSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQ 420
                 .|||..|     |.|.....|..:..|......|..|....|..:...:.|    .|.|.
  Fly   336 YRYVLRPTHGSSEEFVDGLGLQRSSSDHQPPAQRYVLQQTESVDANSMTQPTTTAP----TQYHS 396

  Fly   421 QQQQQQQSVQDVGTGQSQSAQSTP---THQFQAAARPQKALKNFFHRIGSTGMLNHRSHNL---- 478
            .            ||.|....:.|   ..:.:..|:|.|..|.     .|:|...|..|:.
  Fly   397 T------------TGGSVKPPAPPPRTCEKHKPPAKPPKPEKE-----KSSGKHCHVGHSCNPCL 444

  Fly   479 --LKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDD---PTEGLNLQR--------------- 523
              .:...|.:.|.||...:  |.....|:|..   ||.   |:...:.|.
  Fly   445 GHFRWKSAEKSAVPAPDNV--SLDAYDLASPC---CDTHCVPSRRRHRQHKEHTHKHKHRDRERV 504

  Fly   524 EQREQRL-PRIASLKSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPS 587
            |.:|||: |:                     |||..|        |:   |.||  |.||.|
  Fly   505 ESKEQRVRPK---------------------STSHAS--------PN---ANGG--AGSGHH--- 532

  Fly   588 RRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLP------- 645
                              ..:|.:...|.:||.|:|::|.||.|:...||:|....:|
  Fly   533 ------------------HHHHHHHHSHEQQQQQQQQQQQQQQQQQQQQQQQPIQTVPHHHHYPH 579

  Fly   646 QRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYD--SDGGATGARLGNNLSISGGD 708
            |..:|.|..    |::.|..|:     |..|:|.|:|:.|.:.  |...|||.        :...
  Fly   580 QMHNPCQVQ----SQSGSTRSR-----YFDLASGLASHCSLHSCTSSEFATGD--------TASY 627

  Fly   709 TESIASGTL-----------KRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYN 762
            |.||::.||           :::|..|..|.|            ..|..:.      |...|.::
  Fly   628 TTSISTDTLFWDPTSETAQSRQHSTKSRQSYE------------QQPQQQQ------PTHQGHHH 674

  Fly   763 YDYETETIRRRFRQVKLERKCQEDY---IGIVLSPKTVMTNSNE--------------------- 803
            :.:......:|:.....:.:.|:.|   |..|..||:....:|:
  Fly   675 HHHHQGDYHQRYHVTTTQMQPQQIYPNTIAYVQKPKSWDNLANKAGFNVGYGYLDTVAVKPAIKM 739

  Fly   804 --QQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAH 866
              .|.|:.:....|||.....|                 .::::|...   :.||
  Fly   740 QIAQQRHSMPRRNPYGRYSTYG-----------------DVENYAPPP---TEFV---------- 774

  Fly   867 DEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGED 931
            .|:||.    |...|...||:       :...:.|.|:..|...::..:.|   ..|.|:...::
  Fly   775 GELTTT----TTTTITAKSTE-------ELLAACDCLTPQQQAAIKAAQYQ---LSQNQKLSHQN 825

  Fly   932 QCDARSMASVSTMPTP 947
            .|   .:...|.:|.|
  Fly   826 SC---QLGYYSHLPRP 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	16/115 (14%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	24/113 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900