Protein Alignment a and inaD

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 129/636 - (20%)
• Similarity: 224/636 - (35%)
• Gaps: 137/636 - (21%)

  Fly   756 VSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQ 820
            :|.|.:|      ........|.|::..::.: ||.:....|..:.|.:.....|..:.|...|.
  Fly    15 ISFGMHN------PFPELIHMVTLDKTGKKSF-GICIVRGEVKDSPNTKTTGIFIKGIVPDSPAH 72

  Fly   821 KDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMS 885
            ..|||::||.|:::|||.:|            :|.....|||:       ...||..::.|
  Fly    73 LCGRLKVGDRILSLNGKDVR------------NSTEQAVIDLI-------KEADFKIELEI---- 114

  Fly   886 TQRHRLSYVQRTQSTDSLSS--MQSL-QLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTP 947
             |....|..|:.:| |..|:  ||:. :..||:...:|....| ..|:.|...:.||.::...:
  Fly   115 -QTFDKSDEQQAKS-DPRSNGYMQAKNKFNQEQTTNNNASGGQ-GMGQGQGQGQGMAGMNRQQS- 175

  Fly   948 MPLMQHRR-----SSTPRHS--LDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSP 1005
               ||.|.     |...:||  .|....:...:..|.|:.:|..        :..:.:.:|..:.
  Fly   176 ---MQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYE--------IDRASAGNCKLNK 229

  Fly  1006 NHRLLDNENDPANDTDSYTPVYAN---------------RAASVCVASSLADDEKWQLLARKRC- 1054
            ..:..|.|.:   |...||....|               |.||..:..:||..:..|.:|   |
  Fly   230 QEKDRDKEQE---DEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKMA---CF 288

  Fly  1055 ----SEGSALSAT---PNPQQFGQRTHYARNSINL-ANSHYRSLRFAHSRLSSSRLSLFMQAPPN 1111
                ....||.:.   |..:......:..:|..:| |::.::::......:.:||      ..||
  Fly   289 VAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSR------RKPN 347

  Fly  1112 SLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQ----------SLYIKHSPKSVSLFSPNP 1166
            .    ||:...|.....|.:|.|.....|..:.:|.|          .:|.||:.....:|..:
  Fly   348 D----EGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISD- 407

  Fly  1167 YVNASSSPASASTSAG-----------AGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRAS 1220
             :...|:...|....|           ..|:.......|......:.:..||::.||..:..:|:
  Fly   408 -LREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAA 471

  Fly  1221 ---------------MSEGSGRCTP-KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPS 1269
                           ....:....| |.|........|.:|..:.||::: ....|..:..|:|.
  Fly   472 EEKKKEEAKKEEEKPQEPATAEIKPNKKILIELKVEKKPMGVIVCGGKNN-HVTTGCVITHVYPE 535

  Fly  1270 GQAADDGTLQAGDEIVEINGNSVQ--GMSHAETIGLFKNVREGTIVLKILR 1318
            ||.|.|..|:..|.|.:|||..:.  .|:..:...||....|..:.|.:.|
  Fly   536 GQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	16/52 (31%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	24/86 (28%)
inaD	NP_001246470.1	PDZ1_INAD-like	29..115	CDD:467276	26/110 (24%)
		PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like	259..342	CDD:467160	14/85 (16%)
		PDZ3_INAD-like	379..454	CDD:467277	10/76 (13%)
		PDZ4_INAD-like	501..585	CDD:467278	22/84 (26%)
		PDZ5_INAD-like	596..674	CDD:467279