DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and patj

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_005161760.1	Gene:	patj / 368723	ZFINID:	ZDB-GENE-030616-129	Length:	1914	Species:	Danio rerio

Alignment Length:	1516	Identity:	288/1516 - (18%)
Similarity:	470/1516 - (31%)	Gaps:	526/1516 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QQQQQQQQQQQHQAEGSNISHSSNSSSNKSHTPATCSNRLNKSIVSSTSISSSLPDLHDKSPVMI 83
            |:.....::::.:.||.....|.|....:          |.|   :...:..|:.|..|...|
Zfish   707 QENDDDDEEEEEEDEGELALWSPNVQVLE----------LEK---AERGLGFSILDYQDPMDV-- 756

  Fly    84 LSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQ------QHLQH---QQQQQPLRTATPTC 139
                      |.:...:.:...|..|.:.|.:....|      .||:.   .|..:.|::|.|..
Zfish   757 ----------ARSVIVIRSLVPGGVADNHGGIFPGDQLVFVNDTHLETCSLAQAVEVLKSAPPGK 811

  Fly   140 LLSGRQTPSAI-----SVMSLQEATSLHRQ----QQQPHQPPTIYVPVPTKLGNN---VNTGNSS 192
            :..|.:.|.|.     ...||....|:..|    |...|..|    |:|....|.   .:..:..
Zfish   812 VYLGIRKPLAAEDRGSGQQSLWPVESVDEQPTAKQAVSHTLP----PMPEDFVNGSILSDDLDEE 872

  Fly   193 ATLLLS----YGSTSSIANLQQQQQQHAA-------------QYQQYVAQRLHAAS-SSCLYEKG 239
            ..|:|.    |.|..:..:||...::..|             :.||  :.:::..| .|.|.||.
Zfish   873 PELILDAEPRYASPLTTVDLQPDVEKEMAVDEEEEDVDVNVMEDQQ--SSKVNDTSLPSYLSEKS 935

  Fly   240 SNASGGASSNKSSLSLTPN-------------------------GHLPDYKLVTAMPVVVLDDEH 279
            .:....|:|::..|:..|:                         ||...: :.||..  ..|..:
Zfish   936 RSWEEPATSSRYHLNTEPDLQEQVDDDLSMNLEKIQLQPLKIPLGHFTSW-VETADS--DSDSRN 997

  Fly   280 KSNSLPATE-----ASRNSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLAS---TTRNVFTW--- 333
            :.:.|..|:     |.|.|:.:......:.....|:.......|..|.:.|   ..|.|..|
Zfish   998 EGSELTLTDTDNESAQRTSSRNKKRRNQAGPTRGDLPEREEGEGEETPVFSHWGPPRRVEVWAEP 1062

  Fly   334 ----------GKRMSRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTHHKSGSGGSSGPSSAKASAS 388
                      |:.:.::|             |:..:|:.:|....                .:.|
Zfish  1063 EESLGISIVGGRTVIKRL-------------KNGEELKGIFIKQV----------------LADS 1098

  Fly   389 PTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQDVGTGQS------QSAQSTPTHQ 447
            |.|        .|..||  ....|..:.....|....:::||.:....|      ||..|||
Zfish  1099 PAG--------RTGALK--TGDKILQVSGVDLQNASHEEAVQTIKAAPSPVVFIVQSLSSTP--- 1150

  Fly   448 FQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAATTL---YRSSSTSQLSSSSY 509
                 ||..        :.::.:..|::.. ..|.:|.|.|.|....|   ||..|..|......
Zfish  1151 -----RPVS--------VTASSIKQHKAKR-KAAQKAGQGAAPPPMRLPPPYRPPSQVQEEEHEQ 1201

  Fly   510 VKCDD-------------PTEGLNLQREQREQRLP-RIASLKSSSCDDIAKVSSCLTASTSSGSA 560
            .:.|:             |.|.|.::.|:....|. .:|..:..||     :|..:...|:.|.|
Zfish  1202 EEEDEQDTEVIRQRYADLPGELLIVELEKDRNGLGLSLAGNRDRSC-----MSIFVVGITTGGPA 1261

  Fly   561 AGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYA--FLRSRLSVLPEENHGNVPGHLKQQIQRQ 623
                                      ||.|.....  .|.....||...:|.|....:|....:.
Zfish  1262 --------------------------SRDGRIKVGDELLEINSQVLYGRSHQNASAIIKSAASKV 1300

  Fly   624 R----------------------------EQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSR 660
            :                            |.|:.......::.|....||..|||.:..||....
Zfish  1301 KLVLVRNEDAINQMAVTPFPSQPALFSSSETHENPPAVPAEKPQLPESLPLSRSPPENTLNKDQA 1365

  Fly   661 NDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISGGDTESIASGTLKR-NSLIS 724
            ..:.|:.. :|.::.|            :||.:...:|.....:....:|..|...::: .||..
Zfish  1366 CVTATASS-DPTHKSL------------TDGESAVKKLKPAEKLLESPSEQSAKPQVEQIPSLPK 1417

  Fly   725 LSSSEGVGMGMGMSLGLGAPSTR--------NSSICSAPVSLGGYNYDYETETIRRRFRQVKLER 781
            |..|                ||:        .||..|.|||  |.:.|:|
Zfish  1418 LQRS----------------STKPSAGSLEVTSSASSVPVS--GTSPDFE--------------- 1449

  Fly   782 KCQED--YIGIVLSPKTVMTNS--------------NEQQYRYLIVELEPYGMAQKDGRLRLGDE 830
            .|.:|  ...||...:||:..|              :.|....:|.|:...|.|.:||||..||:
Zfish  1450 YCSKDPATCPIVPGQETVIEISKGRSGLGLSIVGGKDTQLDAIVIHEVYEEGAAARDGRLWAGDQ 1514

  Fly   831 IVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTD--------------------- 874
            |:.|||..||.:.....:..|..:  ...:.|.:..||.....:
Zfish  1515 ILEVNGVDLRSVAHEDAIAALRQT--PPKVRLTVLRDEAQYRDEENLDVFPVELQKKTGRGLGLS 1577

  Fly   875 ----------FYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQ---------------LQQE 914
                      |.:.:...|.:....||....:..|.|.....|:.|               |:..
Zfish  1578 IVGKRNGKGVFISDVVKGGAADLDGRLMQGDQILSVDGEDMRQASQETVAAILKCARGKVLLELG 1642

  Fly   915 RIQGHN-TEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTP-RHSLDVGAPEHELLRRRA 977
            |::..: ....:.:||.....|...:|..| ||| |.:....|.|| .:|.::..|    :.:..
Zfish  1643 RLKAASWISSRRTSQGSQMSHASGSSSTPT-PTP-PTVAPPPSQTPNNNSRNIAEP----ISKST 1701

  Fly   978 RSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDNENDPANDTDSY-TPVYANRAASVCVASSLA 1041
            .:..|.|::.:|..|..|.|.|         :...:..|..|...: ..:.||..|:
Zfish  1702 VTEPGVRTVEITRGPTDALGIS---------IAGGKGSPLGDIPIFIAMIQANGVAA-------- 1749

  Fly  1042 DDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFM 1106
                                          :||
Zfish  1750 ------------------------------KTH-------------------------------- 1752

  Fly  1107 QAPPNSLTVGEGVA--NTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVN 1169
                 .|.||:.:.  |:.|....|..|:.|.               :|::..::.|    ..|.
Zfish  1753 -----RLKVGDRIVSINSQSLDGLTHADVVNM---------------LKNAYGAIIL----QVVA 1793

  Fly  1170 ASSSPASASTSAGAGSSLAP---PAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPK 1231
            .::..|.||......||.||   |...|:  .|..|                          .||
Zfish  1794 DTNISAIASQVESLSSSSAPSTNPEVRLV--EPETP--------------------------KPK 1830

  Fly  1232 TITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMS 1296
            :||..||.  :.||||||||..||.|::.|:|||||..|.||.||.|:.||:::.:||.|::|::
Zfish  1831 SITLEKGS--EGLGFSIVGGFGSPHGDLPIYVKTVFGKGAAAVDGRLKRGDQLLSVNGESLEGVT 1893

  Fly  1297 HAETIGLFKNVREGTIVLKIL 1317
            |.:.:.:.|..| |::.|.:|
Zfish  1894 HEQAVAILKKQR-GSVTLSVL 1913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	26/105 (25%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	40/86 (47%)
patj	XP_005161760.1	L27_2	12..69	CDD:117611
		PDZ_signaling	131..>191	CDD:238492
		PDZ_signaling	238..317	CDD:238492
		PDZ	361..449	CDD:214570
		PDZ_signaling	563..627	CDD:238492
		PDZ_signaling	731..817	CDD:238492	18/110 (16%)
		PDZ_signaling	1053..1144	CDD:238492	19/129 (15%)
		PDZ	1222..1307	CDD:214570	20/115 (17%)
		MPDZ_u10	1398..1463	CDD:293272	21/97 (22%)
		PDZ	1464..1549	CDD:214570	22/86 (26%)
		PDZ_signaling	1561..1641	CDD:238492	9/79 (11%)
		PDZ_signaling	1707..1792	CDD:238492	23/187 (12%)
		PDZ_signaling	1829..1913	CDD:238492	40/86 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100