DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and Lnx2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	109/478 - (22%)
Similarity:	172/478 - (35%)	Gaps:	159/478 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   922 EQEQEAQGEDQCDARSMASVSTMPTPMP-------LMQHRRSSTPRHSLDVGAP----------E 969
            |:.:.:|...|.:..:.::|...|.|.|       .:...|:|||       ||          :
  Rat   149 ERRKTSQAHTQIEGETGSTVIDPPGPSPPETDCLGTVPGERNSTP-------APLPVWTEDPGLD 206

  Fly   970 HELLRRRARSSSGQRSLAL--------------------------TPTPL--------FASGSSS 1000
            :......|.:.|.|:.|:|                          ..|||        :..|
  Rat   207 NPAFEESAAADSVQQPLSLPEGEITTIEIHRTNPYIQLGISIVGGNETPLINIVIQEVYRDG--- 268

  Fly  1001 CSSSPNHRLLD-------NENDPANDTDSYTPVYANRAASV------------CVASSLAD---- 1042
             :.:.:.|||.       |..|.:|.:.:|.....::..|.            ..|::.||
  Rat   269 -AIARDGRLLAGDQILQVNNCDISNVSHNYARAVLSQPCSTLHLTVLRERRFGSRANNHADGSAP 332

  Fly  1043 -DEKWQLLARKRCSEGSALSATPNPQQFG----QRTHYARNSINLANSHYRSLRFAHSRLSSSRL 1102
             ||.:|:|..||.|          .:|.|    :||.  ...:.:.:.....|.....||||:..
  Rat   333 RDEVFQVLLHKRDS----------AEQLGIKLVRRTD--EPGVFILDLLEGGLAAQDGRLSSNDR 385

  Fly  1103 SLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPY 1167
            .|.:    |...:.:|   ||...|                   |   .|:.|.:.|:|....|
  Rat   386 VLAI----NGHDLKQG---TPELAA-------------------H---IIQASGERVNLTIARP- 420

  Fly  1168 VNASSSPASASTSAGAGSS--LAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTP 1230
              ....|::.|..|||.||  ..||:    |.|||        ..:::...:         .|..
  Rat   421 --GKPQPSNGSREAGAHSSNHAQPPS----HSRPS--------SHKDLTRCV---------TCQE 462

  Fly  1231 KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGM 1295
            |.||..|.|. :|||.::.|||.|..|.:.|||.:|.|.|..|.||.::.||.::.|||..:..:
  Rat   463 KHITVKKEPH-ESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNL 526

  Fly  1296 SHAETIGLFK-NVREGTIVLKIL 1317
            ||:|.:.:.| :.....::||.|
  Rat   527 SHSEAVAMLKASAASPAVILKAL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	33/87 (38%)
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	12/89 (13%)
		PDZ	335..421	CDD:214570	27/129 (21%)
		PDZ_signaling	462..538	CDD:238492	31/76 (41%)
		PDZ_signaling	595..679	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000