Protein Alignment a and IL16

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_047288403.1
• Gene: IL16 / 3603
• HGNCID: 5980
• Length: 1396
• Species: Homo sapiens
• Alignment Length: 1409
• Identity: 268/1409 - (19%)
• Similarity: 434/1409 - (30%)
• Gaps: 545/1409 - (38%)

  Fly   279 HKSNSLPATEASR--NSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTRNVFTWGKRMSRKL 341
            |:..:.|...|:|  .:.......||..| ||.: .|:|.:|.|...|..        :.:||.|
Human    33 HEVAAKPCPVATRQPRARDQERKKGSFTS-SLRM-ESHSRAGKSRKSAKF--------RSISRSL 87

  Fly   342 DL--LKRSDSPAAAHKSHSD---------LRSLFHSPTH--HKSGSGGSSGPSSAKAS-ASPTGG 392
            .|  .|.||..::..:.:.|         ...:|||...  ..|.:|.||.|..|.|| |:....
Human    88 MLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSSVQLADTSEAGPSSVPDLALASEAAQLQA 152

  Fly   393 HQNSSGST----------TSTLKKCKSGPIET-------IKQRHQQQQQQQQSVQDVGTGQ---- 436
            ..|..|.|          ::...:.|.|.:|.       .|..||:.:....||....|.:
Human   153 AGNDRGKTCRRIFFMKESSTASSREKPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFP 217

  Fly   437 --SQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNL-LKASEAAQQATPAATTLYRS 498
              .:||..|....:...:. :|:|                |..| ..|.:||..:.|.     ||
Human   218 MTKKSAAPTDRQPYSLCSN-RKSL----------------SQQLDCPAGKAAGTSRPT-----RS 260

  Fly   499 SSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSG--SAA 561
            .||:||.        .|:.||      :...:..|..:|..        :..|..|...|  |..
Human   261 LSTAQLV--------QPSGGL------QASVISNIVLMKGQ--------AKGLGFSIVGGKDSIY 303

  Fly   562 GSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQ 626
            |.:|....:..|||...|:....:...               :.|.|..::.|...|...::.:|
Human   304 GPIGIYVKTIFAGGAAAADGRLQEGDE---------------ILELNGESMAGLTHQDALQKFKQ 353

  Fly   627 HQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSS--CLSSNESGYDS 689
            .::....|..:.:.::|                  .|:.|....||.:.|||  |::.:.|.:
Human   354 AKKGLLTLTVRTRLTAP------------------PSLCSHLSPPLCRSLSSSTCITKDSSSF-- 398

  Fly   690 DGGATGARLGNNLSISGGDTESIASGTLKRNSLI----SLSSSEGVGMGMGMSLGLGAPSTRNSS 750
                            ..::.|....|.|.|..|    ||....|||:|:|
Human   399 ----------------ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIG-------------- 433

  Fly   751 ICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEP 815
            :||.|.                 |:.:.          ||                  .:..|.|
Human   434 LCSVPY-----------------FQCIS----------GI------------------FVHTLSP 453

  Fly   816 YGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTK-- 878
            ..:|..|||||.|||||.::...:..: :..||..:||......:.::::......|::...|
Human   454 GSVAHLDGRLRCGDEIVEISDSPVHCL-TLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEA 517

  Fly   879 ----IRIDGMSTQRHR--LSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARS 937
                :.......:||:  |..|:|.:|  |.....:|:.::|:.......:.|:.......|:..
Human   518 VAQAVENTKFGKERHQWSLEGVKRLES--SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSY 580

  Fly   938 MAS-------------------------------------------------------------- 940
            |:.
Human   581 MSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRL 645

  Fly   941 -----------VSTMPTPMPLMQHRRSSTPRHSLD------------------------------ 964
                       :|:.|.|.|....:..|.|:.||:
Human   646 KKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQ 710

  Fly   965 -----------VGAP------------------------------EHELLRRRARSSSGQRSLAL 988
                       .|.|                              :|.||:|:||......:.|.
Human   711 EDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAE 775

  Fly   989 TP------------TPLFASGSSSCSSSPNHRLLDNE--------NDPANDTDSYTP-VYANR-A 1031
            .|            :|:.:.........||..|.:.|        ..|..||.:.|| ||.:. :
Human   776 DPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADS 840

  Fly  1032 ASVCVASSLADDEKW--QLL--ARKRCSE-----GSALSATPNP---QQFGQ--RTHYARNSINL 1082
            ::|.....:|....|  |.|  .|.|.|:     ..|||..|.|   :..|.  |...:.:||..
Human   841 STVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQ 905

  Fly  1083 ANSHYRSLRFAHSRL---SSSRLS-------------------------------LFMQAPPNSL 1113
            ..|.:.:  |..|:|   .:.|||                               |..|.|...|
Human   906 RISSFET--FGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQPEQVL 968

  Fly  1114 TVGE---------GVANTP-------SSTATTTTD-----LTNQQQQQQN-----QQQTHQSLYI 1152
            :.|.         ||:.:|       ..|.....|     |:.|.::.|.     ..|..:|..:
Human   969 SSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPL 1033

  Fly  1153 KHS---------PKSVSLFSPNPYVNAS------------------------SSPASASTSAGAG 1184
            ..|         .|:..|:|.:..|:::                        :||.|:|....|.
Human  1034 TRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAA 1098

  Fly  1185 SSLAPPAA----------ALMHHRPSLPVAK-----------------LTIRDEEMAEVI----- 1217
            :..|..:|          .|..:...|..||                 ..:..||:.::|
Human  1099 NGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1163

  Fly  1218 --RASMSEGSGRCTPKTITFF---KGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGT 1277
              .|::.:..|    ..:|..   :|.|   ||||:.||.|..  |..|.|..|||:|.|:.:||
Human  1164 LDEATLKQLDG----IHVTILHKEEGAG---LGFSLAGGADLE--NKVITVHRVFPNGLASQEGT 1219

  Fly  1278 LQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKL 1321
            :|.|:|::.|||.|::|.:|.:.:.:.:..||....: |:.|||
Human  1220 IQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAV-IVTRKL 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	16/52 (31%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	31/87 (36%)
IL16	XP_047288403.1	PDZ3_PDZD2-PDZ1_hPro-IL-16-like	279..364	CDD:467240	18/107 (17%)
		PDZ4_PDZD2-PDZ2_hPro-IL-16-like	414..503	CDD:467241	31/148 (21%)
		PDZ6_PDZD2-PDZ3_hPro-IL-16-like	1175..1260	CDD:467243	32/90 (36%)
		PDZ7_PDZD2-PDZ4_hPro-IL-16-like	1296..1381	CDD:467244