DRSC/TRiP Functional Genomics Resources

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Protein Alignment a and IL16

DIOPT Version :9

Sequence 1:NP_001014543.1 Gene:a / 43852 FlyBaseID:FBgn0000008 Length:1329 Species:Drosophila melanogaster
Sequence 2:NP_001339615.1 Gene:IL16 / 3603 HGNCID:5980 Length:1382 Species:Homo sapiens


Alignment Length:1409 Identity:268/1409 - (19%)
Similarity:434/1409 - (30%) Gaps:545/1409 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 HKSNSLPATEASR--NSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTRNVFTWGKRMSRKL 341
            |:..:.|...|:|  .:.......||..| ||.: .|:|.:|.|...|..        :.:||.|
Human    20 HEVAAKPCPVATRQPRARDQERKKGSFTS-SLRM-ESHSRAGKSRKSAKF--------RSISRSL 74

  Fly   342 DL--LKRSDSPAAAHKSHSD---------LRSLFHSPTH--HKSGSGGSSGPSSAKAS-ASPTGG 392
            .|  .|.||..::..:.:.|         ...:|||...  ..|.:|.||.|..|.|| |:....
Human    75 MLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSSVQLADTSEAGPSSVPDLALASEAAQLQA 139

  Fly   393 HQNSSGST----------TSTLKKCKSGPIET-------IKQRHQQQQQQQQSVQDVGTGQ---- 436
            ..|..|.|          ::...:.|.|.:|.       .|..||:.:....||....|.:    
Human   140 AGNDRGKTCRRIFFMKESSTASSREKPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFP 204

  Fly   437 --SQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNL-LKASEAAQQATPAATTLYRS 498
              .:||..|....:...:. :|:|                |..| ..|.:||..:.|.     ||
Human   205 MTKKSAAPTDRQPYSLCSN-RKSL----------------SQQLDCPAGKAAGTSRPT-----RS 247

  Fly   499 SSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSG--SAA 561
            .||:||.        .|:.||      :...:..|..:|..        :..|..|...|  |..
Human   248 LSTAQLV--------QPSGGL------QASVISNIVLMKGQ--------AKGLGFSIVGGKDSIY 290

  Fly   562 GSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQ 626
            |.:|....:..|||...|:....:...               :.|.|..::.|...|...::.:|
Human   291 GPIGIYVKTIFAGGAAAADGRLQEGDE---------------ILELNGESMAGLTHQDALQKFKQ 340

  Fly   627 HQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSS--CLSSNESGYDS 689
            .::....|..:.:.::|                  .|:.|....||.:.|||  |::.:.|.:  
Human   341 AKKGLLTLTVRTRLTAP------------------PSLCSHLSPPLCRSLSSSTCITKDSSSF-- 385

  Fly   690 DGGATGARLGNNLSISGGDTESIASGTLKRNSLI----SLSSSEGVGMGMGMSLGLGAPSTRNSS 750
                            ..::.|....|.|.|..|    ||....|||:|:|              
Human   386 ----------------ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIG-------------- 420

  Fly   751 ICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEP 815
            :||.|.                 |:.:.          ||                  .:..|.|
Human   421 LCSVPY-----------------FQCIS----------GI------------------FVHTLSP 440

  Fly   816 YGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTK-- 878
            ..:|..|||||.|||||.::...:..: :..||..:||......:.::::......|::...|  
Human   441 GSVAHLDGRLRCGDEIVEISDSPVHCL-TLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEA 504

  Fly   879 ----IRIDGMSTQRHR--LSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARS 937
                :.......:||:  |..|:|.:|  |.....:|:.::|:.......:.|:.......|:..
Human   505 VAQAVENTKFGKERHQWSLEGVKRLES--SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSY 567

  Fly   938 MAS-------------------------------------------------------------- 940
            |:.                                                              
Human   568 MSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRL 632

  Fly   941 -----------VSTMPTPMPLMQHRRSSTPRHSLD------------------------------ 964
                       :|:.|.|.|....:..|.|:.||:                              
Human   633 KKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQ 697

  Fly   965 -----------VGAP------------------------------EHELLRRRARSSSGQRSLAL 988
                       .|.|                              :|.||:|:||......:.|.
Human   698 EDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAE 762

  Fly   989 TP------------TPLFASGSSSCSSSPNHRLLDNE--------NDPANDTDSYTP-VYANR-A 1031
            .|            :|:.:.........||..|.:.|        ..|..||.:.|| ||.:. :
Human   763 DPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADS 827

  Fly  1032 ASVCVASSLADDEKW--QLL--ARKRCSE-----GSALSATPNP---QQFGQ--RTHYARNSINL 1082
            ::|.....:|....|  |.|  .|.|.|:     ..|||..|.|   :..|.  |...:.:||..
Human   828 STVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQ 892

  Fly  1083 ANSHYRSLRFAHSRL---SSSRLS-------------------------------LFMQAPPNSL 1113
            ..|.:.:  |..|:|   .:.|||                               |..|.|...|
Human   893 RISSFET--FGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQPEQVL 955

  Fly  1114 TVGE---------GVANTP-------SSTATTTTD-----LTNQQQQQQN-----QQQTHQSLYI 1152
            :.|.         ||:.:|       ..|.....|     |:.|.::.|.     ..|..:|..:
Human   956 SSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPL 1020

  Fly  1153 KHS---------PKSVSLFSPNPYVNAS------------------------SSPASASTSAGAG 1184
            ..|         .|:..|:|.:..|:::                        :||.|:|....|.
Human  1021 TRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAA 1085

  Fly  1185 SSLAPPAA----------ALMHHRPSLPVAK-----------------LTIRDEEMAEVI----- 1217
            :..|..:|          .|..:...|..||                 ..:..||:.::|     
Human  1086 NGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1150

  Fly  1218 --RASMSEGSGRCTPKTITFF---KGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGT 1277
              .|::.:..|    ..:|..   :|.|   ||||:.||.|..  |..|.|..|||:|.|:.:||
Human  1151 LDEATLKQLDG----IHVTILHKEEGAG---LGFSLAGGADLE--NKVITVHRVFPNGLASQEGT 1206

  Fly  1278 LQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKL 1321
            :|.|:|::.|||.|::|.:|.:.:.:.:..||....: |:.|||
Human  1207 IQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAV-IVTRKL 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aNP_001014543.1 PDZ_signaling 775..865 CDD:238492 19/89 (21%)
PDZ_signaling 1230..1317 CDD:238492 31/89 (35%)
IL16NP_001339615.1 PDZ_signaling 268..351 CDD:238492 18/105 (17%)
PDZ_signaling 406..488 CDD:238492 30/141 (21%)
COG1615 <911..1006 CDD:332639 16/94 (17%)
PDZ_signaling 1162..1239 CDD:238492 30/81 (37%)
PDZ 1284..1370 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I8096
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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