DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and CG43707

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001260005.1	Gene:	CG43707 / 33601	FlyBaseID:	FBgn0263846	Length:	2021	Species:	Drosophila melanogaster

Alignment Length:	1374	Identity:	247/1374 - (17%)
Similarity:	411/1374 - (29%)	Gaps:	454/1374 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 QQQQQQHLQHQQQQQPLRTATPTCLLSGRQTPSAISVMSLQ------------------------ 156
            :|.:.:....:.|||.:..|....|...:..|..:.|..::
  Fly   699 KQHKAEIAMRKMQQQRMAQAAALTLPKPKSQPVEVEVRKVELEPSDEEEDEDEVSEPEEEDDGEE 763

  Fly   157 ---EATSLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQ 218
               :...|....|:..:|  :|..: |..|..|             ..||...::|.::.|.
  Fly   764 IDDDEQKLETDLQEDEEP--LYENI-TPCGCRV-------------VPTSDAEDIQDKRSQF--- 809

  Fly   219 YQQYVAQRLHAASSSCLYEKGSNASGGASSNKSSLSLTPNG-HLPDYKLVTAMPVVVLDDEHKSN 282
                   |..:.|....||.           |:|.:.||.| .||      :.|.....||..:|
  Fly   810 -------RKRSVSLDDDYEA-----------KASETPTPTGLRLP------STPASPCRDELLAN 850

  Fly   283 --SLPATEASRNSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTRNVFTW--GKRMSRKLDL 343
              :.|::::..|.|:..:.:|..|.:.:.|..:.....|..|.:|   |:...  .||.:..|..
  Fly   851 VSTYPSSDSLANDNTRDHSDGIWNESQVTVLTAEQRDISDGSYSS---NLLLTPSSKRKNLLLQH 912

  Fly   344 LKRS--DSPAAAHKSHSDLRSLFHSPTHHKSGSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKK 406
            .:||  |:.|...:..|....|...|...|:.:..:|.|:|.:....|..  ...:.||...|..
  Fly   913 QQRSSVDTDALDFEEQSPTYGLQTLPKIIKTPTPTTSRPTSTQPMMPPPA--IAVTPSTNQILDS 975

  Fly   407 CKSGPIE---------------------TIKQRHQQQQQQQQSVQDVGTGQSQSAQSTPTHQFQA 450
            |.|.|:.                     ..||||...........|.......|..||.|.::..
  Fly   976 CISSPLPKRSMVARGSVPDARQLMFTSGATKQRHSDASFLPMGAADYARSADISECSTNTDEYAT 1040

  Fly   451 AARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDP 515
            ..                        :..|.:..:.|::....|  .:.|:.:.:||.|...:|
  Fly  1041 CT------------------------DTSKRTPVSTQSSQLEKT--HAGSSFESASSLYSMRED- 1078

  Fly   516 TEGLNLQREQRE---QRLPRIASLKS--SSCDDIAK--VSSCLTASTSSGSA---AGSLGSPPSS 570
                .||.:::|   |.....|.|||  .|..::.:  .|..::::|||||.   ..::.||...
  Fly  1079 ----LLQHDEKERDKQTTLTKAQLKSPIGSVAELTRKSPSHSISSTTSSGSCPVLGAAIKSPAKE 1139

  Fly   571 AAAGGGGTANSGQHDPSRRGAFP-----------------YAFLRSRLSVLPEENHGNVPG---- 614
            :......::.:.|...|.....|                 ..:..|.....|.|......|
  Fly  1140 SLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPHEEDDEEQGTRSK 1204

  Fly   615 --HLKQQIQRQREQ-------HQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITS-KDW 669
              .|:|:.:|:|.:       .:::.|.|....:..:...:..||||::...:....|.:. |.:
  Fly  1205 ARRLRQEDERKRRKTSMKLDIEKENMRALTSPIKKPTGSSKITSPEQSISGTMDNGSSPSKMKRF 1269

  Fly   670 EPLYQRLSSCLSSNESGYDSDGGATGARLGN------NLSISGGDTESIASGTLKRNSLISLSSS 728
            .|..:|     ...:|..:....|...|...      .||...||||          .|:..|.|
  Fly  1270 RPKIRR-----QLRKSSREDVLAAAAVRRSRATPTIFGLSSGSGDTE----------LLLDASMS 1319

  Fly   729 EGVGMGMGMS--LGLGAPS------TRNSSI------------------CSAPVSL--------G 759
            .|...|...|  ..:.|||      |..||:                  |:.|.||        .
  Fly  1320 TGAVAGTTTSAVTSVSAPSSASKLPTSESSVTTQPEAVVAPLPAKKPHSCATPTSLLSPKLPTTS 1384

  Fly   760 GYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGR 824
            |......::|.:.:.:.::              |.::|...|:...|            ::.||.
  Fly  1385 GTQSKSTSDTFQLKAKSIE--------------SLRSVSPGSDSVFY------------SEADGN 1423

  Fly   825 LRLGDEI-VNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQR 888
            ...|::. .:..||.:.|.|....:..|....|::.  ..|..|.|...:|| ....:...:|||
  Fly  1424 AASGEQSHCHHCGKEMEGKQQSNTISELAGDSVESI--PYIEQDIVKPPSDF-ADSPVTTKTTQR 1485

  Fly   889 HRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQH 953
            ......:|.:|.:        :...||.:.:.|.||
  Fly  1486 LYKKMDKRFRSEE--------RYHGERGRHYKTRQE----------------------------- 1513

  Fly   954 RRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTP-LFASGSSSC----SSSPNHRLLDNE 1013
                                ..||:|....|..:|..|| |..:|||.|    :....|.:....
  Fly  1514 --------------------NIRAKSEERGRIPSLPNTPVLRPAGSSPCVLPDTEQSQHIIYKGH 1558

  Fly  1014 NDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARN 1078
            .|...    ||              .|.||:.|                |....|...|:...|.
  Fly  1559 YDAGR----YT--------------RLTDDDLW----------------TQLDHQCFDRSRERRA 1589

  Fly  1079 SINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQ 1143
            |.......:...:....||...|.:|.|.                                   .
  Fly  1590 STESEKGFHAKYQVILHRLVQRRCTLEMY-----------------------------------H 1619

  Fly  1144 QQTHQS-------------------LYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAP 1189
            :|.|.|                   ::.::|.:.:.|.:.|      |:|.|.
  Fly  1620 RQKHNSFLWAKCKEISAKSFRNIFAVFTQYSGQMIELIASN------STPDSI------------ 1666

  Fly  1190 PAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDS 1254
                   .|....|.||.:........:.:.:|.|: ....||:......|  ..||.|.|.:.
  Fly  1667 -------RRKLEEVLKLMLLVWARESYVISKLSNGA-HGVDKTVVVKSDSG--EFGFRIHGSKP- 1720

  Fly  1255 PKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRR 1319
                  :.|..:.|...|...| |:.||.|:.:||..|....|.|.:   |...:|...|
  Fly  1721 ------VVVAAIEPETPAESSG-LEVGDIIISVNGVQVLDKHHTEVV---KIAHDGCEKL----- 1770

  Fly  1320 KLQKAKSMG 1328
            :||.|:::|
  Fly  1771 ELQVARTIG 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	13/90 (14%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	23/86 (27%)
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	81/452 (18%)
		PDZ_signaling	1702..1775	CDD:238492	23/90 (26%)
		PH	1792..1894	CDD:278594
		PH-like	1792..1893	CDD:302622
		PH-like	1911..2011	CDD:302622
		PH	1921..2014	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900