DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and baz

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001036283.1	Gene:	baz / 32703	FlyBaseID:	FBgn0000163	Length:	1520	Species:	Drosophila melanogaster

Alignment Length:	1451	Identity:	267/1451 - (18%)
Similarity:	461/1451 - (31%)	Gaps:	476/1451 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QQQQQQQQQHQAEGSNISHSSNSSSNKSHTPATCSNRLNKSIVSSTSISSSLPDLHDKSPVMILS 85
            ||..||...|...|.|.::||.|...:|.              ....:..:...:.:|...|:|.
  Fly   286 QQTYQQGSHHAGHGQNGAYSSKSLPRESK--------------RKEPLGQAYESIREKDGEMLLI 336

  Fly    86 CTTLASN-GATAT--------AAVTATATGTAATSG-----------------GSLQQQQQQHLQ 124
            .....|. |.||.        ..|.....|:.|..|                 |..:.|.|:.|:
  Fly   337 INEYGSPLGLTALPDKEHGGGLLVQHVEPGSRAERGRLRRDDRILEINGIKLIGLTESQVQEQLR 401

  Fly   125 HQQQQQPLRTATPTCLLSG-----RQTPSAISVMSLQEATSLHRQQQQPHQPPTIYVPVPTKLGN 184
            ...:...||..    :|.|     :|..|.::.| ::.||.  ...::||..|.
  Fly   402 RALESSELRVR----VLRGDRNRRQQRDSKVAEM-VEVATV--SPTRKPHAAPV----------- 448

  Fly   185 NVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASGGASSN 249
                           |::..:||.::            :.:::     ..:.:||.|..|.:.:.
  Fly   449 ---------------GTSLQVANTRK------------LGRKI-----EIMLKKGPNGLGFSVTT 481

  Fly   250 KSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSLPATEASRNSN----------SSSNMNGSSN 304
            :.:   ...||.|.|               ..|.||...|..:..          ..:.|.|.:.
  Fly   482 RDN---PAGGHCPIY---------------IKNILPRGAAIEDGRLKPGDRLLEVDGTPMTGKTQ 528

  Fly   305 SNSLDVSNSNSHSGSSTSLASTTRNVFTWGKRMSRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTH 369
            ::.:.:..       .....:|.|.|      :||:.:|.:::|.||
  Fly   529 TDVVAILR-------GMPAGATVRIV------VSRQQELAEQADQPA------------------ 562

  Fly   370 HKSGSGGSSGPS-------SAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQ 427
             :..:|.:..||       :|.|.|.|....::||..:..|               ||||.|..:
  Fly   563 -EKSAGVAVAPSVAPPAVPAAAAPAPPIPVQKSSSARSLFT---------------HQQQSQLNE 611

  Fly   428 SVQDVGTGQSQSAQST--------------------PTHQFQAA----ARPQKALKNF-----FH 463
            |...:..| |:||.|.                    |.|..:.|    :...|...|.     ..
  Fly   612 SQHFIDAG-SESAASNDSLPPSSNSWHSREELTLHIPVHDTEKAGLGVSVKGKTCSNLNASGSSA 675

  Fly   464 RIGSTGMLNHRS------HNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQ 522
            ..||.|::.|..      .|::....|::..        |.....||.|         ..|::|:
  Fly   676 SSGSNGLMKHDGDLGIFVKNVIHGGAASRDG--------RLRMNDQLLS---------VNGVSLR 723

  Fly   523 REQREQRLPRIAS---------------------LKSSSCDDIAKVSSCLTASTSSGSAAGSLGS 566
            .:...:.:..:..                     |:|:|..||...|:..:.|.|:.|.
  Fly   724 GQNNAEAMETLRRAMVNTPGKHPGTITLLVGRKILRSASSSDILDHSNSHSHSHSNSSG------ 782

  Fly   567 PPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEE-----NHGNVPGHLKQQIQR---- 622
              .|.:.|.|...||..:.....||       :.:.:.||:     |.|...|....::.|
  Fly   783 --GSNSNGSGNNNNSSSNASDNSGA-------TVIYLSPEKREQRCNGGGGGGSAGNEMNRWSNP 838

  Fly   623 ------------------QREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVS-RNDS---IT 665
                              .::.|||......||:|      |||.|...:.::.: ||:|   .|
  Fly   839 VLDRLTGGICSSNSAQPSSQQSHQQQPHPSQQQQQ------QRRLPAAPVCSSAALRNESYYMAT 897

  Fly   666 SKDWEPLYQRLSSC--------------LSSNESGYDSDG---GATGARLGNNLSISG-GDTESI 712
            :.:|.|....|.:.              :|........||   ..:.|....||::.. |...:.
  Fly   898 NDNWSPAQMHLMTAHGNTALLIEDDAEPMSPTLPARPHDGQHCNTSSANPSQNLAVGNQGPPINT 962

  Fly   713 ASGT--------LKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETET 769
            ..||        ...:|.:||.::.||......:||..:.|.::.:...|. ..|.|..:.:...
  Fly   963 VPGTPSTSSNFDATYSSQLSLETNSGVEHFSRDALGRRSISEKHHAALDAR-ETGTYQRNKKLRE 1026

  Fly   770 IRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNV 834
            .|.|.|:::|.:...  |.|.:.|....:.::|.|...|
  Fly  1027 ERERERRIQLTKSAV--YGGSIESLTARIASANAQFSGY-------------------------- 1063

  Fly   835 NGKHLRGIQSF--AEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRT 897
              ||.:...|.  .|.|:.|::....      |.|::..:          |.|..      ::::
  Fly  1064 --KHAKTASSIEQRETQQQLAAAEAE------ARDQLGDL----------GPSLG------MKKS 1104

  Fly   898 QSTDSLSSM-QSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRH 961
            .|.:||.:| |.||:..|. :||...:....:|.:  |:...|.||          ...:|.||.
  Fly  1105 SSLESLQTMVQELQMSDEP-RGHQALRAPRGRGRE--DSLRAAVVS----------EPDASKPRK 1156

  Fly   962 SLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSS----PN--------HRLLDNEN 1014
            :..:...:||......|:...|.||        ..|...|.||    |:        .|...|..
  Fly  1157 TWLLEDGDHEGGFASQRNGPFQSSL--------NDGKHGCKSSRAKKPSILRGIGHMFRFGKNRK 1213

  Fly  1015 DPANDTDSYTPVYANRAASVCVASS--LADDEKWQLLARKRCSE--GSALSA------------- 1062
            |.....|:|....:...:.|..|:|  |...::.||...::..:  .:||:|
  Fly  1214 DGVVPVDNYAVNISPPTSVVSTATSPQLQQQQQQQLQQHQQQQQIPTAALAALERNGKPPAYQPP 1278

  Fly  1063 --TPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSS 1125
              .|.|...|....:..:..|....||.:....|           .|...:.::.|:...:...:
  Fly  1279 PPLPAPNGVGSNGIHQNDIFNHRYQHYANYEDLH-----------QQHQQHQISGGDSTTSISET 1332

  Fly  1126 TATTTTDLTNQQQQQQN-----QQQTHQSLYIKHSPKS--VSLFSPNPYVNASSSPASASTSAGA 1183
            .:.:|.:...||..:|.     :.:.||..:.:.|.:|  ||:.               |||:|:
  Fly  1333 LSESTLECMRQQVIRQRIKVEAESRRHQHYHSQRSARSQDVSMH---------------STSSGS 1382

  Fly  1184 -GSSLAPPAAALMHHRPSLPVAKL-TIRDEEMAEVIRA-SMSEGSGRCTPKTITFFKGPGLKSLG 1245
             ..|||.|.|.....||.....:. |::.:.:..:..: |.|..|...:|..:..:|...:.  |
  Fly  1383 QPGSLAQPQAQSNGVRPMSSYYEYETVQQQRVGSIKHSHSSSATSSSSSPINVPHWKAAAMN--G 1445

  Fly  1246 FSIVGGRDSPKGNMGIFVKTV 1266
            :|......|.: :.|.||..|
  Fly  1446 YSPASLNSSAR-SRGPFVTQV 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	14/91 (15%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	9/37 (24%)
baz	NP_001036283.1	DUF3534	<62..174	CDD:288873
		PDZ_signaling	341..412	CDD:238492	14/70 (20%)
		CRS1_YhbY	<390..>436	CDD:294440	11/50 (22%)
		PDZ_signaling	462..548	CDD:238492	17/121 (14%)
		PDZ_signaling	<686..753	CDD:238492	8/83 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900