DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and gopc

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_956851.1	Gene:	gopc / 326887	ZFINID:	ZDB-GENE-030131-5086	Length:	455	Species:	Danio rerio

Alignment Length:	480	Identity:	87/480 - (18%)
Similarity:	166/480 - (34%)	Gaps:	123/480 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 SAAGSLGSPPSSAAAGGGGTANSG-------------------------------QHDPSRRG-- 590
            ::||..|||.|..:||......||                               |.|.:..|
Zfish     3 ASAGGAGSPGSGLSAGPAAATGSGMSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQ 67

  Fly   591 -----AFPYAFLRSRLSVLPEENH----------GNVPGHLKQQIQRQREQHQQ----HQRDLLQ 636
                 :..:|.|..:...:.:.||          ..:.....:::..::|.|:|    |...|..
Zfish    68 KMTSLSSCFAQLCHKAQTIFQLNHKLEAQLVDLRSELTDVQAEKVVVEKEVHEQLLQLHAMQLKL 132

  Fly   637 QEQTSS-----------PLPQRRSPEQAMLNNVSRNDSITSKDWE---PLYQRLSSCLSSNESGY 687
            |.:...           |:|.....|:.:  ..|:.:.:.....|   .:.::.:..|..:.:..
Zfish   133 QAKGGQAVDSDSIKDRMPVPSVEEKEKEL--EASKKEKVKEVKLEAEVKMLKKENEALRRHIAVL 195

  Fly   688 DSDGGATGARLG------------NNLSISGGDTESIASGTL--KRNSLISLSSSEGVGMGMGMS 738
            .::  ..||||.            ..:.:.|.|.:..|...|  :..:.|.|...:.|
Zfish   196 QAE--VYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTV------- 251

  Fly   739 LGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRR-----FRQVKLERKCQEDYIGIVLSPKTVM 798
              :.|...||......|..:|     ::|:::::.     .|:|.|.:   ||:.|:.:|    :
Zfish   252 --IRACRGRNDPKKPLPSPVG-----HDTDSLKKTQGVGPIRKVVLTK---EDHEGLGIS----I 302

  Fly   799 TNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLV 863
            |...|.....||.|:.|...|::.|.|.:||.|:.||..:||..:....|..|.....:...::|
Zfish   303 TGGKEHGVPILISEIHPTQPAERCGGLHVGDAILAVNNINLRDAKHKEAVTILSQQRGEIEFEVV 367

  Fly   864 IAHDEVTTVTDFYTKIRIDGMSTQRHRL--------SYVQRTQSTDSLSSMQSL--QLQQERIQG 918
            ....||.:..:   .:..:..|..|:||        |.......|...:|:|::  .|...|.:.
Zfish   368 YVAPEVDSDDE---NVEYEDDSGHRYRLYLDELEEASAANHNNGTADPASLQAVGKHLVNNRTEN 429

  Fly   919 HNTEQEQEAQGEDQCDARSMASVST 943
            .:.....|...:|:....:.::.|:
Zfish   430 GDVGLSSECPSDDKTSKTAESAESS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	26/89 (29%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
gopc	NP_956851.1	PDZ_signaling	285..367	CDD:238492	25/88 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900