DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and PsGEF

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	1705	Identity:	298/1705 - (17%)
Similarity:	508/1705 - (29%)	Gaps:	588/1705 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QQQHQAEGSNISHSSNSSSNKSHTPATC-------SNRLNKSIVSSTSISSSLPDLHDKSPVMIL 84
            |::..:|||....::...:.....|.|.       .::|:.|.:..|::...|..:.:.:...:.
  Fly    69 QRRSFSEGSGPRQATPQLAALRCLPRTTGGAVALEDSQLSSSRMGDTTLDRMLDAIIESARKEVR 133

  Fly    85 SCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQ---QQQQPLRTAT---------- 136
            ...||...|||.:..:.|.....:.||...::.:...||:.|   :::.|.:|.|
  Fly   134 CTKTLPGAGATTSTTILADNAEWSETSVHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAK 198

  Fly   137 ---PTCLLSGRQTPSAISVMSLQEATSLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLS 198
               |..|:.  .|...:|..|...::.|...:||..:..::..|..|...:...|.:|.::...|
  Fly   199 KLEPLQLVP--STKRCLSFSSSSASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSS 261

  Fly   199 YGSTS-----------SIANLQQQQQQHAAQYQQYVAQRLHAASSSCL--YEK------------ 238
            .|...           |||...::||.:....:....||.|.:.:..:  |.|
  Fly   262 NGGADMEASQRGSIDVSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGY 326

  Fly   239 GSNASGGASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSLPATEASRNSNSSSNMNGSS 303
            |.::|||:.|:             .|:. ||:        |:.:..|..:...|...||....:.
  Fly   327 GGHSSGGSMSS-------------GYQR-TAV--------HRHSGRPYFDQRFNFQISSGEETAG 369

  Fly   304 NSNSLDVSNSNSHSGSSTSLASTTRNVFTWG--KRMSRKLDLLKRSDSPAAAHKSHSDLRSLF-- 364
            ....|.|.:.:.|..|.....|..:.....|  :|.:.:|..|:.:.:.|.        ||.|
  Fly   370 QYLQLAVWHRDRHLNSVPVTQSEWQARVKSGTERRTAERLAKLENAGNEAK--------RSEFLG 426

  Fly   365 ------HSPTHHKSGSGGSSGPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQ 423
                  :...|..||....|....|:|...||..|.....:.....|:      ||...:.|.:|
  Fly   427 CSTFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQ------ETEAAKDQDKQ 485

  Fly   424 QQQQSVQ-----------DVGTGQSQSAQST-----------------------PTHQFQAAARP 454
            |.....:           .|.||....:.|.                       |    |...:|
  Fly   486 QDDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLP----QQPQQP 546

  Fly   455 QKALKNFFHRIGSTGMLNHRSHNLLKASEA-AQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEG 518
            .|..|...|:..:...|..|...|...::. |...|..|......||.|:.:.|:....::.|.|
  Fly   547 MKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNANHLNNGTSG 611

  Fly   519 LNLQ---------------REQR--------------EQR----------LPRI----ASLKSSS 540
            ...|               |:|:              |:|          .||:    |.|.:..
  Fly   612 GRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWTHPPRVEKIEAGLSADR 676

  Fly   541 CD---------------------DIAKV----SSCLT-------------------------AST 555
            |.                     |:..:    .|.||                         .||
  Fly   677 CGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFRRSGAGATTITSTDLGQNNVHIST 741

  Fly   556 SSGSAAGSLGSPPSSAA--AGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPG---- 614
            ..|:|.| |||...:.|  |.|..|..|.|...|.| ..|.|...||.:........::..
  Fly   742 RLGAAVG-LGSEEHTLATTATGTTTVMSLQRTTSTR-IQPLANSMSRPATACSGTTSSIEAAKRR 804

  Fly   615 -HL------KQQIQRQREQHQQHQRDLLQQEQTSS------------PLPQRRSPEQAMLNNVSR 660
             ||      |:.|....:..::....|:.:||..:            ||.:|:
  Fly   805 LHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFTAALHFGVDRFVQPLGERK------------ 857

  Fly   661 NDSITSKDWEPLYQRLSS------------CLSSNESGYDSDGGATGARLGNNLSISGGDTESIA 713
             |.|:..|...|:|.:..            |.|..:........|:...|....:|... .:...
  Fly   858 -DLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQDQEPQMNFASRVYLSKTTAICAA-YKKYC 920

  Fly   714 SGTLKRNSLISLSSSEGVGMGM--------------GMSLGLGAPSTRNSSICSAPVSLGGYNYD 764
            :| :||...:.::.|...|...              .:::.:..|......|......|.| |..
  Fly   921 NG-IKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPDLTMFIHRPLQHFREILKLMQLLAG-NCH 983

  Fly   765 YETE----------TIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMA 819
            .:||          .::..:|::.:.....|.     |.....:....:.:.|.:..:.:|:.:|
  Fly   984 VDTEEHKNFSTVINELQAAYREITVSSGLMEP-----LGEGRPLLTLQDLESRMVFTKCKPFTLA 1043

  Fly   820 QKDGRLRLGDEIVNVNGKHLR--------GIQSFAEVQR-----------LLSSFVDNCIDLVIA 865
            .:..:...|.::..|.|:.::        .|..||:|.|           .:::.||:|.
  Fly  1044 VQGRQWIFGGDLSRVEGRSVKPYWTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCF----- 1103

  Fly   866 HDEVTTVTDFYTKIRIDGMSTQ-----------------RHRLSYVQRTQSTD------------ 901
            |....| |:|...:..:|...:                 ..|.|.:.|..|.:
  Fly  1104 HMRKKT-TEFRLTVDPNGRLAESPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQ 1167

  Fly   902 ------------------------------------------SLSSMQSLQLQQ----------- 913
                                                      .|.|:.|:.|:|
  Fly  1168 IFLVNAALGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSH 1232

  Fly   914 ---------------ERIQGHN-------TEQEQ----------EAQGEDQCDARSMASVSTMPT 946
                           :|..|||       .||.:          ...|..:..|..:|:......
  Fly  1233 GHVHSATGVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRILNKTGTPKSSALHLANWMKGQL 1297

  Fly   947 PMPLMQHRRSSTPRHSLDVGAPEHELL---------------RRRARSSSGQRSLA-----LTPT 991
            .....|.|.::..|...:|.|.:.:|:               |::....:.:.:||     |:..
  Fly  1298 DKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTRQQLEKRTKELNLAKENGGLSAR 1362

  Fly   992 PLFA----SGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLAR- 1051
            |.|.    ||....|.|..             :|.|:...|....|| ::.|.:.....|:..|
  Fly  1363 PNFGGKRLSGVEELSMSAT-------------SDIYSTSEAEGVTSV-ISQSHSTTSDSQITVRS 1413

  Fly  1052 ---------------KRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSR 1101
                           |.|.:.....|.|...  |...:.:...:.|.|    ||:..||:.|.:|
  Fly  1414 SPIVLDKLAVCRHCHKNCQQSGPGGARPGGG--GGVNNSSSTPVLLCN----SLKVQHSQSSPNR 1472

  Fly  1102 L---------SLFMQAPPNSLTVGEGVANTPSSTATTTTD------------------------- 1132
            .         :..|..|.||...|.|..:..|.:::|.|.
  Fly  1473 CCKLSNGIAGATEMANPKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQL 1537

  Fly  1133 LTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSP----------NPYVNASSSP---ASASTSAGAG 1184
            :|::..|.|::........:.:|.:|....:|          :|.|:.||.|   .||....|:.
  Fly  1538 ITDEISQSQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSP 1602

  Fly  1185 SSLAPP----AAALMHHRPSLPVA----KLTIRDEEMAEVIRASMSEGSG--------------- 1226
            ..|.||    ..|.|...|..|.|    |..:...|.|.::|:|.::|||
  Fly  1603 KPLPPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPA 1667

  Fly  1227 -------RCTPKTIT 1234
                   ||||:..|
  Fly  1668 KYAACHCRCTPEDFT 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	17/108 (16%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	2/5 (40%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674	20/108 (19%)
		C2	286..>381	CDD:278593	22/116 (19%)
		PDZ_signaling	644..716	CDD:238492	11/71 (15%)
		RhoGEF	831..1000	CDD:295373	28/184 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900