DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and Ush1c

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	153/831 - (18%)
Similarity:	247/831 - (29%)	Gaps:	317/831 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 LPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISGGD 708
            :|.:.|||:.:             .|:.:.|.:|      |||        |.|.|  ||..|..
  Rat   170 IPVKSSPEEPL-------------KWQYVDQFVS------ESG--------GVRGG--LSSPGNR 205

  Fly   709 TESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRR 773
            |      |.::...|||..|.|:|                .||.|.|:...|
  Rat   206 T------TKEKKVFISLVGSRGLG----------------CSISSGPIQKPG------------- 235

  Fly   774 FRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKH 838
                                              ..:..::|..::.:.| |..||:||.|||..
  Rat   236 ----------------------------------IFVSNVKPGSLSAEVG-LETGDQIVEVNGID 265

  Fly   839 LRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQR----TQS 899
            ...: ...|...:|.|.....|.:|........:||   :.|::  ..::|.|   ||    .|.
  Rat   266 FTNL-DHKEAVNVLKSSRSLTISIVAGAGRELFMTD---RERLE--EARQHEL---QRQELLMQK 321

  Fly   900 TDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLD 964
            ..::.|.:.||.|||..:....|..|:|..|::...:.|..:|         :.......:...|
  Rat   322 RLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIS---------EEEEKFKKQWEED 377

  Fly   965 VGAPEHELLRRRARSSSGQRSLALTPTPL---------------------------FASGSSSCS 1002
            .|:.|..:|.:...:.       :.|.||                           .|...|...
  Rat   378 WGSKEQLILPKTITAE-------VHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKKKAKYDSLQD 435

  Fly  1003 SSPNHRLLDNE----NDPANDTDSYTPVYANRAA---SVCVASSLADDEKWQLLARKRC------ 1054
            ...|.:.|:.|    .:.....:....:..||.|   |......|.:.||.|....:.|
  Rat   436 LRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKTQYWVERLCQTRLQQ 500

  Fly  1055 -----SEGSALSATPNP------------QQFGQRTHYARNSINLANSHYRSL------RFAHSR 1096
                 :|.:.::..|.|            ::|....|.          |...|      .|.:..
  Rat   501 ISSAENEITEMTTGPPPPPPSVSPLVPPLRRFAGGIHL----------HTTDLDDIPLDMFYYPP 555

  Fly  1097 LSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSL 1161
            .:.|.|.:....||         :|.||.......      ....:...:..|.:::|:|..:.:
  Rat   556 KTPSALPVMPHPPP---------SNPPSKVPAPPV------LPSSDHMSSSSSPWVQHTPPPIPI 605

  Fly  1162 FSP------------------------NPY-VNASSSPAS---ASTSAGAGSSLA------PPA- 1191
            ..|                        :|: ......||:   |:|.:|..:|..      |||
  Rat   606 PPPPSIPTQDLTPTRPLPSALEEVLGNHPFRTGDPGHPATDWEANTHSGKPTSSPTPERSFPPAP 670

  Fly  1192 --------------------AALMHHRPSL---PVAKLTIRDEEMAE---VIRASM-------SE 1223
                                ..::|...:.   |..|..:..:||.:   |.:.:.       .|
  Rat   671 KTFCPSPQPPRGPGVSTISKPVMVHQEHNFVYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEE 735

  Fly  1224 G---SGRCTPKTITFFKGPGLK--------SLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGT 1277
            |   ....:|:.|.   |..::        ||..::.||.|||.|.  :.|..|:..|.|...|.
  Rat   736 GFDPYSMFSPEQIA---GKDVRLLRIKKEGSLDLALEGGVDSPVGK--VVVSAVYEGGAAERHGG 795

  Fly  1278 LQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKLQKAKSMG 1328
            :..||||:.|||..|...:.||.                 ...||||.:.|
  Rat   796 VVKGDEIMAINGKIVTDYTLAEA-----------------EAALQKAWNQG 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	15/89 (17%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	26/94 (28%)
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492
		PDZ_signaling	209..289	CDD:238492	25/144 (17%)
		Cgr1	<316..>358	CDD:281823	11/41 (27%)
		PDZ_signaling	751..838	CDD:238492	28/98 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900