Protein Alignment a and Mpdz

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_001416564.1
• Gene: Mpdz / 29365
• RGDID: 3105
• Length: 2068
• Species: Rattus norvegicus
• Alignment Length: 1724
• Identity: 338/1724 - (19%)
• Similarity: 568/1724 - (32%)
• Gaps: 585/1724 - (33%)

  Fly    13 YSTLAAQQQQQQQQQQQ-------HQAEGSN----ISHSSNSSSNKSHTPATCSNRLNKSIVSST 66
            |..|:.:.::.:..||:       .:..|.|    ::|.|..|.|..         |..|:.::.
  Rat   510 YPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSG---------LGISLEATV 565

  Fly    67 S---ISSSLPDLHDKSPVMILSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQQQ 128
            .   |.|.||:                  |....:....:.......:|.:|..:..|.:.:..:
  Rat   566 GHHFIRSVLPE------------------GPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILK 612

  Fly   129 QQPLRTATPTCLLSGRQT--PSAISVMSLQEATSLHRQQ--QQPHQPPTIYVPVPTKLGNNVNTG 189
            :.|:......|    |:|  |:|:|.:   ::..:|..:  ::||          ..||..:.:.
  Rat   613 ELPIDVTMVCC----RRTVPPTALSEV---DSLDIHDLELTEKPH----------IDLGEFIGSS 660

  Fly   190 NSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASG---------- 244
            .:...:|    :.|.:       .|:|.:.|..:|. ..|...:...||||...|
  Rat   661 ETEDPML----AMSDV-------DQNAEEIQTPLAM-WEAGIQAIELEKGSRGLGFSILDYQDPI 713

  Fly   245 -GASSNKSSLSLTPNGHL-PDYKLVTAMPVVVLDDEHKSNSL--PATEASRNSNSSSNMNGSSNS 305
             .|::.....||.|.|.. .|.:|.....::.::|.:..||.  .|.||.:.:.|.....|.:..
  Rat   714 DPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKP 778

  Fly   306 NSLDVSNSNSHSGSSTSLAS--TTRNVFTWGKRMSR-KLDLLKRSDSPAAAHKSHSDLRSLFHSP 367
            ..|........:...|.|.|  |.:.:....|.:.| .|.|:   |:|.|...:.|...|.| ||
  Rat   779 LPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDKALFRADLALI---DTPDAESVAESRFESQF-SP 839

  Fly   368 --------------THHKSGSGGSS-GPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQ 417
                          .|..:.|.|.: |||   ..:||.....|||               :.:..
  Rat   840 DNDSVYSTQASVLSLHDGACSDGMNYGPS---LPSSPPKDVTNSS---------------DLVLG 886

  Fly   418 RHQQQQQQQQSVQDVGTG---QSQSAQSTPTHQFQAAA--------RPQKALKNFFHRIGSTGML 471
            .|       .|::::.|.   |.|.|.|.||....||.        .|..|::..:....:....
  Rat   887 LH-------LSLEELYTQNLLQRQHAGSPPTDMSPAATSGFTVSDYTPANAVEQKYECANTVAWT 944

  Fly   472 NHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASL 536
            ..:..:.|..:|.| .|.||....|.:..:|.:|.:         |.:.|| ...::...|..:
  Rat   945 PSQLPSGLSTTELA-PALPAVAPKYLTEQSSLVSDA---------ESVTLQ-SMSQEAFERTVT- 997

  Fly   537 KSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGG----GTANSG--------QHDPSRR 589
                   |||.||.|..:.|:..  ..||....|...||.    |....|        :...|..
  Rat   998 -------IAKGSSSLGMTVSANK--DGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLT 1053

  Fly   590 GAFPYAFLRSRLSVLPEENHGNVPGHLK-----------QQIQRQREQHQQHQRDLLQQEQTSS- 642
            .|...|.||....:.|:......|...:           :.::..|....|....::..:..||
  Rat  1054 NAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSY 1118

  Fly   643 ------PLPQRR--SPEQAMLNNVSRNDSITSKDW-EP----LYQRLSSCLSSNESGYDSDGGAT 694
                  .||:|.  ..|::.|.|.:.:      .| :|    |::..|..|..:..|    |...
  Rat  1119 TGRDIPELPEREEGEGEESELQNAAYS------SWSQPRRVELWREPSKSLGISIVG----GRGM 1173

  Fly   695 GARLGNNLSISG-------GDTESIASGTLKRNSLI----------------------------- 723
            |:||.|...:.|       .|:.:..:||||....|
  Rat  1174 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVF 1238

  Fly   724 -------------------------SLSSSEGVGMGMGMSLGLGAPS-----TRNSSICSAPVSL 758
                                     |.||:......:.::.. .|||     :..:::||.|.|.
  Rat  1239 MVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSD-KAPSQSESESEKATLCSVPSSS 1302

  Fly   759 GGY------------------------NYDYETETIRRRF-------RQVKLERKCQEDYIGIVL 792
            ...                        .:.|..:.|:.|:       ..::||:    .:.|:.|
  Rat  1303 PSVFSEMSSDYAQPSATTVAEDEDKEDEFGYSWKNIQERYGTLTGQLHMIELEK----GHSGLGL 1363

  Fly   793 SPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHL--RGIQSFAEVQRLLSS- 854
            |   :..|.:..:....||.::|.|.|.:||||::.||::.:||:.|  |..|:.:.:.:...|
  Rat  1364 S---LAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSK 1425

  Fly   855 ----FVDNCIDLV--------IAHDEVTTVTDFYTKIRIDGMSTQRHRL--SYVQRTQSTD--SL 903
                |:.|. |.|        .|.|.:.:.::          |.|...:  |......:.|  ||
  Rat  1426 VKIIFIRNA-DAVNQMAVCPGSAADPLPSTSE----------SPQNKEVEPSITTSASAVDLSSL 1479

  Fly   904 SSMQSLQL------------QQERIQGHNTEQEQEAQGE---------DQCDARSMASVSTMPTP 947
            :::..|:|            :::.:.|...:...|..|.         |:..|.....|:..|..
  Rat  1480 TNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGAAKDGRLKPGDRILAVDDELVAGCPIE 1544

  Fly   948 --MPLMQHRRSSTPRHSLDVGA--PEHELLRRRARSSSGQR------------------SLALTP 990
              :.|::..:::.   .|.|||  |..:.:...|.::||:|                  |.:.:.
  Rat  1545 KFISLLKTAKTTV---KLTVGAENPGCQAVPSAAVTASGERKDSSQTPAVPAPDLEPIPSTSRSS 1606

  Fly   991 TP-LFASGSSSCSSSPN-------------------------------HRLLDN----------- 1012
            || :|||..::|...|.                               |.:.:.
  Rat  1607 TPAIFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWA 1671

  Fly  1013 ---------------ENDPANDTDSYTP------VYANRA----ASVCVASSLADDEKWQLLARK 1052
                           .:|.|.:....||      :|.:.|    ..||        :.:.:..:|
  Rat  1672 GDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVC--------DTFTVELQK 1728

  Fly  1053 RCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGE 1117
            |..:|..||..      |:|..   ..:.:::.....:..|..||        ||.....:..||
  Rat  1729 RPGKGLGLSIV------GKRND---TGVFVSDIVKGGIADADGRL--------MQGDQILMVNGE 1776

  Fly  1118 GVANTPS---------STATTTTDL--------TNQQQQQQNQQQTHQSLY--------IKHSPK 1157
            .|.|...         |..|.|.::        .::::..|:.|.:..||.        |..|..
  Rat  1777 DVRNATQEAVAALLKCSLGTVTLEVGRIKAAPFHSERRPSQSSQVSESSLSSFSLPRSGIHTSES 1841

  Fly  1158 SVSLFSPNPY---------VNASSSPASA---STSAGAGSSL--APPAAALMH------------ 1196
            |.|....|..         |.....||.|   |.:.|.||.|  .|...|:||
  Rat  1842 SESSAKKNALASEIQGLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLR 1906

  Fly  1197 -----------------HRPSLPVAK------------------LTIRDEEMAEVIRASMSEGSG 1226
                             |..::.:.|                  :|...:|:|....|.....|.
  Rat  1907 VGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSS 1971

  Fly  1227 RCTP--------KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDE 1283
            ...|        ||||..:||  ..||||||||..||.|::.|:|||||..|.||:||.|:.||:
  Rat  1972 TIFPDDLGPPQSKTITLDRGP--DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQ 2034

  Fly  1284 IVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            |:.:||.|::|::|.|.:.:.|..: ||:.|.:|
  Rat  2035 IIAVNGQSLEGVTHEEAVAILKRTK-GTVTLMVL 2067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	20/67 (30%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	42/84 (50%)
Mpdz	NP_001416564.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1124..1143		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1326		7/51 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1447..1468		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1574..1608		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1809..1848		8/38 (21%)