DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment a and Mpdz

DIOPT Version :9

Sequence 1:NP_001014543.1 Gene:a / 43852 FlyBaseID:FBgn0000008 Length:1329 Species:Drosophila melanogaster
Sequence 2:XP_006238402.1 Gene:Mpdz / 29365 RGDID:3105 Length:2068 Species:Rattus norvegicus


Alignment Length:1724 Identity:338/1724 - (19%)
Similarity:568/1724 - (32%) Gaps:585/1724 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 YSTLAAQQQQQQQQQQQ-------HQAEGSN----ISHSSNSSSNKSHTPATCSNRLNKSIVSST 66
            |..|:.:.::.:..||:       .:..|.|    ::|.|..|.|..         |..|:.::.
  Rat   510 YPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSG---------LGISLEATV 565

  Fly    67 S---ISSSLPDLHDKSPVMILSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQQQ 128
            .   |.|.||:                  |....:....:.......:|.:|..:..|.:.:..:
  Rat   566 GHHFIRSVLPE------------------GPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILK 612

  Fly   129 QQPLRTATPTCLLSGRQT--PSAISVMSLQEATSLHRQQ--QQPHQPPTIYVPVPTKLGNNVNTG 189
            :.|:......|    |:|  |:|:|.:   ::..:|..:  ::||          ..||..:.:.
  Rat   613 ELPIDVTMVCC----RRTVPPTALSEV---DSLDIHDLELTEKPH----------IDLGEFIGSS 660

  Fly   190 NSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYEKGSNASG---------- 244
            .:...:|    :.|.:       .|:|.:.|..:|. ..|...:...||||...|          
  Rat   661 ETEDPML----AMSDV-------DQNAEEIQTPLAM-WEAGIQAIELEKGSRGLGFSILDYQDPI 713

  Fly   245 -GASSNKSSLSLTPNGHL-PDYKLVTAMPVVVLDDEHKSNSL--PATEASRNSNSSSNMNGSSNS 305
             .|::.....||.|.|.. .|.:|.....::.::|.:..||.  .|.||.:.:.|.....|.:..
  Rat   714 DPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGVAKP 778

  Fly   306 NSLDVSNSNSHSGSSTSLAS--TTRNVFTWGKRMSR-KLDLLKRSDSPAAAHKSHSDLRSLFHSP 367
            ..|........:...|.|.|  |.:.:....|.:.| .|.|:   |:|.|...:.|...|.| ||
  Rat   779 LPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDKALFRADLALI---DTPDAESVAESRFESQF-SP 839

  Fly   368 --------------THHKSGSGGSS-GPSSAKASASPTGGHQNSSGSTTSTLKKCKSGPIETIKQ 417
                          .|..:.|.|.: |||   ..:||.....|||               :.:..
  Rat   840 DNDSVYSTQASVLSLHDGACSDGMNYGPS---LPSSPPKDVTNSS---------------DLVLG 886

  Fly   418 RHQQQQQQQQSVQDVGTG---QSQSAQSTPTHQFQAAA--------RPQKALKNFFHRIGSTGML 471
            .|       .|::::.|.   |.|.|.|.||....||.        .|..|::..:....:....
  Rat   887 LH-------LSLEELYTQNLLQRQHAGSPPTDMSPAATSGFTVSDYTPANAVEQKYECANTVAWT 944

  Fly   472 NHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASL 536
            ..:..:.|..:|.| .|.||....|.:..:|.:|.:         |.:.|| ...::...|..: 
  Rat   945 PSQLPSGLSTTELA-PALPAVAPKYLTEQSSLVSDA---------ESVTLQ-SMSQEAFERTVT- 997

  Fly   537 KSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGG----GTANSG--------QHDPSRR 589
                   |||.||.|..:.|:..  ..||....|...||.    |....|        :...|..
  Rat   998 -------IAKGSSSLGMTVSANK--DGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLT 1053

  Fly   590 GAFPYAFLRSRLSVLPEENHGNVPGHLK-----------QQIQRQREQHQQHQRDLLQQEQTSS- 642
            .|...|.||....:.|:......|...:           :.::..|....|....::..:..|| 
  Rat  1054 NAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSY 1118

  Fly   643 ------PLPQRR--SPEQAMLNNVSRNDSITSKDW-EP----LYQRLSSCLSSNESGYDSDGGAT 694
                  .||:|.  ..|::.|.|.:.:      .| :|    |::..|..|..:..|    |...
  Rat  1119 TGRDIPELPEREEGEGEESELQNAAYS------SWSQPRRVELWREPSKSLGISIVG----GRGM 1173

  Fly   695 GARLGNNLSISG-------GDTESIASGTLKRNSLI----------------------------- 723
            |:||.|...:.|       .|:.:..:||||....|                             
  Rat  1174 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVF 1238

  Fly   724 -------------------------SLSSSEGVGMGMGMSLGLGAPS-----TRNSSICSAPVSL 758
                                     |.||:......:.::.. .|||     :..:::||.|.|.
  Rat  1239 MVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSD-KAPSQSESESEKATLCSVPSSS 1302

  Fly   759 GGY------------------------NYDYETETIRRRF-------RQVKLERKCQEDYIGIVL 792
            ...                        .:.|..:.|:.|:       ..::||:    .:.|:.|
  Rat  1303 PSVFSEMSSDYAQPSATTVAEDEDKEDEFGYSWKNIQERYGTLTGQLHMIELEK----GHSGLGL 1363

  Fly   793 SPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHL--RGIQSFAEVQRLLSS- 854
            |   :..|.:..:....||.::|.|.|.:||||::.||::.:||:.|  |..|:.:.:.:...| 
  Rat  1364 S---LAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSK 1425

  Fly   855 ----FVDNCIDLV--------IAHDEVTTVTDFYTKIRIDGMSTQRHRL--SYVQRTQSTD--SL 903
                |:.|. |.|        .|.|.:.:.::          |.|...:  |......:.|  ||
  Rat  1426 VKIIFIRNA-DAVNQMAVCPGSAADPLPSTSE----------SPQNKEVEPSITTSASAVDLSSL 1479

  Fly   904 SSMQSLQL------------QQERIQGHNTEQEQEAQGE---------DQCDARSMASVSTMPTP 947
            :::..|:|            :::.:.|...:...|..|.         |:..|.....|:..|..
  Rat  1480 TNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGAAKDGRLKPGDRILAVDDELVAGCPIE 1544

  Fly   948 --MPLMQHRRSSTPRHSLDVGA--PEHELLRRRARSSSGQR------------------SLALTP 990
              :.|::..:::.   .|.|||  |..:.:...|.::||:|                  |.:.:.
  Rat  1545 KFISLLKTAKTTV---KLTVGAENPGCQAVPSAAVTASGERKDSSQTPAVPAPDLEPIPSTSRSS 1606

  Fly   991 TP-LFASGSSSCSSSPN-------------------------------HRLLDN----------- 1012
            || :|||..::|...|.                               |.:.:.           
  Rat  1607 TPAIFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWA 1671

  Fly  1013 ---------------ENDPANDTDSYTP------VYANRA----ASVCVASSLADDEKWQLLARK 1052
                           .:|.|.:....||      :|.:.|    ..||        :.:.:..:|
  Rat  1672 GDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEDVC--------DTFTVELQK 1728

  Fly  1053 RCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGE 1117
            |..:|..||..      |:|..   ..:.:::.....:..|..||        ||.....:..||
  Rat  1729 RPGKGLGLSIV------GKRND---TGVFVSDIVKGGIADADGRL--------MQGDQILMVNGE 1776

  Fly  1118 GVANTPS---------STATTTTDL--------TNQQQQQQNQQQTHQSLY--------IKHSPK 1157
            .|.|...         |..|.|.::        .::::..|:.|.:..||.        |..|..
  Rat  1777 DVRNATQEAVAALLKCSLGTVTLEVGRIKAAPFHSERRPSQSSQVSESSLSSFSLPRSGIHTSES 1841

  Fly  1158 SVSLFSPNPY---------VNASSSPASA---STSAGAGSSL--APPAAALMH------------ 1196
            |.|....|..         |.....||.|   |.:.|.||.|  .|...|:||            
  Rat  1842 SESSAKKNALASEIQGLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLR 1906

  Fly  1197 -----------------HRPSLPVAK------------------LTIRDEEMAEVIRASMSEGSG 1226
                             |..::.:.|                  :|...:|:|....|.....|.
  Rat  1907 VGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAFTGLTSS 1971

  Fly  1227 RCTP--------KTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDE 1283
            ...|        ||||..:||  ..||||||||..||.|::.|:|||||..|.||:||.|:.||:
  Rat  1972 TIFPDDLGPPQSKTITLDRGP--DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLKRGDQ 2034

  Fly  1284 IVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            |:.:||.|::|::|.|.:.:.|..: ||:.|.:|
  Rat  2035 IIAVNGQSLEGVTHEEAVAILKRTK-GTVTLMVL 2067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aNP_001014543.1 PDZ_signaling 775..865 CDD:238492 27/104 (26%)
PDZ_signaling 1230..1317 CDD:238492 43/94 (46%)
MpdzXP_006238402.1 L27_2 6..63 CDD:117611
PDZ_signaling 140..222 CDD:238492
PDZ_signaling 256..335 CDD:238492
PDZ 374..463 CDD:214570
PDZ_signaling 552..621 CDD:238492 13/95 (14%)
PDZ_signaling 693..776 CDD:238492 20/82 (24%)
PDZ_signaling 993..1063 CDD:238492 19/79 (24%)
PDZ_signaling 1150..1241 CDD:238492 17/94 (18%)
PDZ 1348..1433 CDD:214570 24/91 (26%)
PDZ_signaling 1482..1561 CDD:238492 11/81 (14%)
MPDZ_u10 1563..1624 CDD:293272 14/60 (23%)
PDZ 1625..1709 CDD:214570 6/83 (7%)
PDZ_signaling 1721..1801 CDD:238492 19/96 (20%)
PDZ_signaling 1858..1943 CDD:238492 15/84 (18%)
PDZ_signaling 1984..2067 CDD:238492 42/85 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19964
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

Return to query results.
Submit another query.