Protein Alignment a and Grip2

DIOPT Version :9

• Sequence 1: NP_001014543.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_006506166.1
• Gene: Grip2 / 243547
• MGIID: 2681173
• Length: 1049
• Species: Mus musculus
• Alignment Length: 625
• Identity: 133/625 - (21%)
• Similarity: 198/625 - (31%)
• Gaps: 201/625 - (32%)

  Fly   768 ETIRRRFRQVKLER--KCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDE 830
            ::|...||.:.:..  |.:...:|:.:|..|      ::..:..:..|.|.|:|.:...|.:||.
Mouse    49 QSIPEEFRGITMVELIKREGSTLGLTISGGT------DKDGKPRVSNLRPGGLAARSDLLNVGDY 107

  Fly   831 IVNVNGKHLR--------------GIQSFAEVQ------------RLLSSFVD-------NCIDL 862
            |.:|||.||.              |.:...||:            |::|..||       |....
Mouse   108 IRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGF 172

  Fly   863 VI---AHDEVTTVTDF-YTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQ 923
            |:   ||:::...... .|.:|..|.:.:...|....|..|.|.             |..|....
Mouse   173 VLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDG-------------IPLHGASH 224

  Fly   924 EQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLAL 988
            ........||...::..|                    ..||..|:      ...::||...:.:
Mouse   225 ATAIATLQQCSHEALFQV--------------------EYDVATPD------TVANASGPLVVEI 263

  Fly   989 TPTPLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASS--------LADD-- 1043
            ..||..|.|.|..:.|  ||     |.||...|...|      |||...|.        ||.|
Mouse   264 AKTPGSALGISLTTGS--HR-----NKPAITIDRIKP------ASVVDRSGALHAGDHILAIDGT 315

  Fly  1044 --------EKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSINLANSH--YR---SLRFAHS 1095
                    |..:|||  ..:|...|...|:||  .:|......::.:..|.  :|   |....||
Mouse   316 STEHCSLVEATKLLA--SVTEKVRLEILPSPQ--SRRPLKPPEAVRIQRSEQLHRWDPSAPSCHS 376

  Fly  1096 -RLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSV 1159
             |.|..|...:....|:.   ...|::||.|:.|.....
Mouse   377 PRPSHCRAPTWAAGGPDQ---SRSVSSTPFSSPTMNPAF-------------------------- 412

  Fly  1160 SLFSPNPYVNASS---SPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASM 1221
                  |..|||:   .|.|..|:||....      ....||.||.:|..|:
Mouse   413 ------PCANASTLPRGPMSPRTTAGRRRQ------RRKEHRSSLSLASSTV------------- 452

  Fly  1222 SEGSGR---CTPKTITFFKGPGLKSLGFSIVGG------RDSPKGNMGIFVKTVFPSGQAADDGT 1277
              |.|.   .|..|.....|..|...|..:.||      ..||.     .|:.:.|...|...|.
Mouse   453 --GPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP-----LVRFIEPDSPAERCGL 510

  Fly  1278 LQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            ||.||.::.|||.:.:..:..|...|   :|:..:..|::
Mouse   511 LQVGDRVLAINGIATEDGTMEEANQL---LRDAALARKVV 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	27/127 (21%)
		PDZ_signaling	1230..1317	CDD:238492	23/92 (25%)
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492	19/87 (22%)
		PDZ_signaling	160..243	CDD:238492	17/115 (15%)
		PDZ_signaling	258..341	CDD:238492	26/97 (27%)
		PDZ_signaling	463..551	CDD:238492	23/93 (25%)
		PDZ_signaling	564..647	CDD:238492
		PDZ_signaling	664..744	CDD:238492
		PDZ_signaling	947..1026	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900