DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and GRIP1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	988	Identity:	203/988 - (20%)
Similarity:	335/988 - (33%)	Gaps:	263/988 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 AQSTPTHQFQAAAR--PQKALKNFFHRIGSTGMLNHRSHNLLKASEA---------AQQATPAAT 493
            |:|...|||..:..  |...:.|.. ...:.|.:.::......||||         .....|...
Human    12 AESVKKHQFSTSESYLPATLILNSI-SFNTDGSIQYKEKLYFSASEALDAYIDDFHLNYEPPDID 75

  Fly   494 T-----------LYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKV 547
            |           |.:|:|    ..|.|.|....|:..:.....|.|.:|.  ..|.|:..::.|.
Human    76 TKVNLDQSPLEFLAKSNS----DESPYTKSASQTKPPDGALAVRRQSIPE--EFKGSTVVELMKK 134

  Fly   548 SSCLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSV-LPEENHGN 611
            .......|.||..... |.|..|....||..|.|.|.|..       .::::...: |.:..|..
Human   135 EGTTLGLTVSGGIDKD-GKPRVSNLRQGGIAARSDQLDVG-------DYIKAVNGINLAKFRHDE 191

  Fly   612 VPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRL 676
            :...||          ...:|.:|:.|....|:..:.|      :.:.|...:|      |::
Human   192 IISLLK----------NVGERVVLEVEYELPPVSVQGS------SVIFRTVEVT------LHK-- 232

  Fly   677 SSCLSSNESGYDSDGGATGARLGNNLSI-----SGGDTESIASGTLKRNSLISLSSSEGVGMGMG 736
                ..|..|:...|||...|..:...:     .||..:  ..||:|...  .|.|.:|:.:
Human   233 ----EGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPAD--REGTIKPGD--RLLSVDGIRL--- 286

  Fly   737 MSLGLGAPSTRNSSI---CSAPVSLGGYNYDYET-ETIRRRFRQVKLE-RKCQEDYIGIVLSPKT 796
                ||.......||   |....:| ...||... :::......:.:| .|.....:|:.|   |
Human   287 ----LGTTHAEAMSILKQCGQEAAL-LIEYDVSVMDSVATASGPLLVEVAKTPGASLGVAL---T 343

  Fly   797 VMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCID 861
            .....|:|.  .:|.:::...:|.:.|.|.:||.|::::|..:. ..:.||..:.|::..|....
Human   344 TSMCCNKQV--IVIDKIKSASIADRCGALHVGDHILSIDGTSME-YCTLAEATQFLANTTDQVKL 405

  Fly   862 LVIAHDEVTTVTDFYTKIRIDG---MSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQ 923
            .::.|.:        |::.:.|   :..||.     .|..:.||.:|..|         ..:|..
Human   406 EILPHHQ--------TRLALKGPDHVKIQRS-----DRQLTWDSWASNHS---------SLHTNH 448

  Fly   924 EQEAQGEDQC--------------DARSMASVSTMPTPM---PLMQHRRSSTPRHSLDVGAPEHE 971
            .......|.|              ...::.|.|..||.|   .|......:.|| ||...:|...
Human   449 HYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPR-SLYSTSPRGT 512

  Fly   972 LLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDNEN-------DP------------- 1016
            ::|||.:....:.||:|..:.:..:|          :::..|.       ||
Human   513 MMRRRLKKKDFKSSLSLASSTVGLAG----------QVVHTETTEVVLTADPVTGFGIQLQGSVF 567

  Fly  1017 ANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSIN 1081
            |.:|.|..|:     .|...|.|.|:          ||          ...|.|.|. .|.|.|.
Human   568 ATETLSSPPL-----ISYIEADSPAE----------RC----------GVLQIGDRV-MAINGIP 606

  Fly  1082 LANSHY-RSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQ 1145
            ..:|.: .:.:.......:|:::|.::     ..|.|.|  .|||..
Human   607 TEDSTFEEASQLLRDSSITSKVTLEIE-----FDVAESV--IPSSGT------------------ 646

  Fly  1146 THQSLYIKHSPK-SVSLFSP------NPYVNASSSPASASTSAGA---GSSL------------A 1188
            .|..|..||:.: .:::.||      :|.|.:.....|.:...|.   |..|            .
Human   647 FHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSM 711

  Fly  1189 PPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITF--FKGPGLKSLGFSIVGG 1251
            ..|..::.....|  .||.||.:|    ..:...|.||... .|:..  :.||    ||.:|.|.
Human   712 EDAVQILQQCEDL--VKLKIRKDE----DNSDEQESSGAII-YTVELKRYGGP----LGITISGT 765

  Fly  1252 RD--SPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVL 1314
            .:  .|     |.:.::...|.|...|.:..||.|:.||.:|::|...:|.|.|.:...| |:.|
Human   766 EEPFDP-----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-TVTL 824

  Fly  1315 KILRR-KLQKAKS 1326
            ||.:: ..|.|.|
Human   825 KIKKQTDAQSASS 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	19/90 (21%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	26/90 (29%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	19/97 (20%)
		PDZ_signaling	227..310	CDD:238492	22/106 (21%)
		PDZ_signaling	325..408	CDD:238492	19/88 (22%)
		PDZ_signaling	545..633	CDD:238492	21/113 (19%)
		PDZ_signaling	646..730	CDD:238492	16/103 (16%)
		PDZ_signaling	746..827	CDD:238492	26/91 (29%)
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900