DRSC/TRiP Functional Genomics Resources

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Protein Alignment a and PDZD2

DIOPT Version :9

Sequence 1:NP_001014543.1 Gene:a / 43852 FlyBaseID:FBgn0000008 Length:1329 Species:Drosophila melanogaster
Sequence 2:XP_005248326.1 Gene:PDZD2 / 23037 HGNCID:18486 Length:2873 Species:Homo sapiens


Alignment Length:1575 Identity:302/1575 - (19%)
Similarity:479/1575 - (30%) Gaps:575/1575 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 SNIS-HSSNSSSNKSHTPATCSNRLNKSIVSSTSISSSLPDLHDKSPVMILSCTTLASNGATATA 98
            |.:| |..:.|.::......||.|      ...:..||...|..::.:...|...|:...:|...
Human  1582 SRVSLHKEDPSESEEEQIEICSTR------GCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRE 1640

  Fly    99 AVTATATGTAA-----TSG-------GSLQQQQQQHLQHQQQQQPLRTA---TPTCLLSGRQTPS 148
            :|.:.....|.     |||       ..|:...|:|..|..    :.|:   .|:|   ..:|..
Human  1641 SVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHAD----ISTSQNHRPSC---AEETTE 1698

  Fly   149 AISVMSLQEATSLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQ 213
            ..|..|..|.:.|.:..:..|.||                      ::||  |.:.:..|:....
Human  1699 VTSASSAMENSPLSKVARHFHSPP----------------------IILS--SPNMVNGLEHDLL 1739

  Fly   214 QHAAQYQQYVAQRLHAASSSCLYEKGSNASGGASS-----NKSSLSLTPNGHLPDY--------- 264
            ......|               ||...||:...||     .|:..|:..|.|:.:.         
Human  1740 DDETLNQ---------------YETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQK 1789

  Fly   265 -KLVTAMPVVVLDDE-HKSNS--------------LPATEASRNSNSSSNMNGSSNSNSLDVSNS 313
             |::...|::....| :|.|.              :||    |:.:|...|..||....:.|.:|
Human  1790 PKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPLMPA----RSPDSKIQMVSSSQKKGVTVPHS 1850

  Fly   314 -----NSHSGSSTSLASTTRNVFTWG---------KRMSRKLDLLKRSDSPA--AAHKSHSDLRS 362
                 .:......|..|....:.|.|         ||:|.|......|::||  |.....:|.|.
Human  1851 PPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRK 1915

  Fly   363 LFHSP-THHKSGSG-----------------------------------GSSGPSSAKASASPTG 391
            ...|| |.||:.|.                                   .:|||  .|.|.|.|.
Human  1916 PLISPQTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGP--LKPSVSDTS 1978

  Fly   392 ----------------------------GHQNSSGSTTSTLKKCK---------SGPIETIKQRH 419
                                        ...:....||....||:         |||:.....|:
Human  1979 IRTFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRN 2043

  Fly   420 QQQQQQQQSVQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSH--NLLKAS 482
                  ..||    .|..||.....:|.....|:|:...:.     |...|.:.|..  |.||..
Human  2044 ------GMSV----AGNRQSEPRLASHVAADTAQPRPTGEK-----GGNIMASDRLERTNQLKIV 2093

  Fly   483 EAAQQAT--------PAAT------------------TLYR---SSSTSQLSSSSYVKCDDPTEG 518
            |.:.:|.        ||.:                  .|||   .||||..||            
Human  2094 EISAEAVSETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSS------------ 2146

  Fly   519 LNLQREQREQRLPR---IASLKSSSCDDIAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGGG--- 577
            |.....|.||.:.|   :|.|.|||......:.....:...|...:.|.|.|.:|...|..|   
Human  2147 LPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDH 2211

  Fly   578 --------------TANSGQHDPSRRGAFPYAFLRSR-------LSVLPE--ENHGNVPG----- 614
                          .|....|. .|.|..|::..|||       .||:||  .:.|.:|.     
Human  2212 LYFTPRPATRTYSMPAQFSSHF-GREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQ 2275

  Fly   615 ---HLKQQIQRQREQHQQHQRDLLQQEQTSSPLP------------QRRSPEQA----------- 653
               .:|..:...|......:.|::..::||..:.            ::..|.::           
Human  2276 GIYSVKPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK 2340

  Fly   654 MLNNVSRND------------SITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISG 706
            ...|::..|            |::||  .|:.:|.|..:.|...|:..|..|...|    .|:|.
Human  2341 SFENLANADRPVAKSGASPFLSVSSK--PPIGRRSSGSIVSGSLGHPGDAAARLLR----RSLSS 2399

  Fly   707 GDTESIASGTL-----KRNSLISL---------SSSEGVGMGMGMSLG----------LGAPSTR 747
            .......:|||     |..|:::|         :||:|....:..|||          |.:|..|
Human  2400 CSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKR 2464

  Fly   748 NSSIC----SAPVSLGGYNYDYETETIRRRFRQVK------LERKCQEDYIGIVLSPKTVMTNSN 802
            |.|..    .:|||             |.:.::::      |::.|.|||..   .|..|:..:.
Human  2465 NKSSVRHTQPSPVS-------------RSKLQELRALSMPDLDKLCSEDYSA---GPSAVLFKTE 2513

  Fly   803 EQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHD 867
                    :|:.|        |...|.....|:.....|.::              |        
Human  2514 --------LEITP--------RRSPGPPAGGVSCPEKGGNRA--------------C-------- 2540

  Fly   868 EVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQ 932
                          .|.|..:   :....|.|:.|.:...:..|...|....|.:|...:.|:.|
Human  2541 --------------PGGSGPK---TSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQ 2588

  Fly   933 CDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASG 997
            .....::||.:..|.:.|:|..::.:                                       
Human  2589 RLQSVLSSVGSKSTILTLIQEAKAQS--------------------------------------- 2614

  Fly   998 SSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLA---DDEKWQLLARKRCSEGSA 1059
                         :||.|...       :..||.....:..|:|   |.|...:...:..|:|:|
Human  2615 -------------ENEEDVCF-------IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAA 2659

  Fly  1060 -LSATPNPQQFGQRTHYARNSINLAN-SHYRSLRFAH-SRLSSSRLSLF-----------MQAPP 1110
             ...|.|...|    ..:.|..:||. :|...|:..| ::|....|.:.           .|.||
Human  2660 SQEGTMNRGDF----LLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP 2720

  Fly  1111 NSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPA 1175
            .:  .|:|:.:  ..|......:.|.:|:.|.|||        ||.:              .||.
Human  2721 TA--NGKGLLS--RKTIPLEPGIENTEQRMQVQQQ--------HSQE--------------GSPR 2759

  Fly  1176 SASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPG 1240
            ....:...|||.....:..:|             |....||::.|                    
Human  2760 IGRPTVLLGSSAVIRRSVAVH-------------DALCVEVLKTS-------------------- 2791

  Fly  1241 LKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFK 1305
             ..||.|:.||:.|..|:..:.:|.|:..|.|...|.::|||||:.|||..:.|:.|.:...:.|
Human  2792 -AGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMK 2855

  Fly  1306 NVREGTIVLKILRRK 1320
            :|.||.:.|.|.:.:
Human  2856 SVPEGPVQLLIRKHR 2870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aNP_001014543.1 PDZ_signaling 775..865 CDD:238492 14/95 (15%)
PDZ_signaling 1230..1317 CDD:238492 27/86 (31%)
PDZD2XP_005248326.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 589..670 CDD:238492
PDZ_signaling 726..810 CDD:238492
PDZ_signaling 2623..2694 CDD:238492 18/74 (24%)
PDZ 2785..2867 CDD:214570 30/102 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I8096
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto91104
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9923
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.890

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