DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and LNX2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_699202.1	Gene:	LNX2 / 222484	HGNCID:	20421	Length:	690	Species:	Homo sapiens

Alignment Length:	663	Identity:	139/663 - (20%)
Similarity:	223/663 - (33%)	Gaps:	175/663 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   681 SSNESGYDSDGGATGARLGNNLSISGGDTESIASGTL---KRNSLISLSS-SEGVGM-GMGMSLG 740
            |..::..:::.|.|.......||   .:.:.:.:|.:   :..:..|||: ||..|: .......
Human   153 SRTQAEIENENGPTLLDPAGTLS---PEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEES 214

  Fly   741 LGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQ 805
            .||.:|:.      |:||.    :.|..||       ::.|  ...||.:.:|    :...||..
Human   215 AGADTTQQ------PLSLP----EGEITTI-------EIHR--SNPYIQLGIS----IVGGNETP 256

  Fly   806 YRYLIVELEPY--GMAQKDGRLRLGDEIVNVNGKHLRGI-QSFAEVQRLLSSFVDNCIDLVIAHD 867
            ...:::: |.|  |:..:||||..||:|:.||..::..: .::|   |.:.|...|.:.|.:..:
Human   257 LINIVIQ-EVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYA---RAVLSQPCNTLHLTVLRE 317

  Fly   868 EVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQ 932
                        |..|.....|          :||.|..:  ::.|..:...::.::...:...:
Human   318 ------------RRFGNRAHNH----------SDSNSPRE--EIFQVALHKRDSGEQLGIKLVRR 358

  Fly   933 CDARSMASVSTMPTPMPLMQHRRSSTPR------HSLDVGAPEHELLRRRARSSSGQRSLALTPT 991
            .|...:..:..:...:.....|.||..|      |.|..|.||   |..:...:||:|.......
Human   359 TDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPE---LAAQIIQASGERVNLTIAR 420

  Fly   992 PLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANRAAS-----VCVASSLADDEKWQLLAR 1051
            |......::...:.||......:.|        |.|.:|.:|     .||.
Human   421 PGKPQPGNTIREAGNHSSSSQHHTP--------PPYYSRPSSHKDLTQCVT-------------- 463

  Fly  1052 KRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFM-QAPPNSLTV 1115
              |.|..........:..|......|.|                  .|..|.:|: ..||:....
Human   464 --CQEKHITVKKEPHESLGMTVAGGRGS------------------KSGELPIFVTSVPPHGCLA 508

  Fly  1116 GEG-VANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASAST 1179
            .:| :............|||                                  |.|.|.|.|..
Human   509 RDGRIKRGDVLLNINGIDLT----------------------------------NLSHSEAVAML 539

  Fly  1180 SAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPG---- 1240
            .|.|.|    ||.||......: |.:.|...||.....  |.:|.....:|..:.:...|.
Human   540 KASAAS----PAVALKALEVQI-VEEATQNAEEQPSTF--SENEYDASWSPSWVMWLGLPSTLHS 597

  Fly  1241 ----------LKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGM 1295
                      |.|.|||||||.:....|...|:||:.....|..||.|:.||.||.:||.|..||
Human   598 CHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662

  Fly  1296 SHAETIGLFKNVR 1308
            ||:..:.:.|..|
Human   663 SHSALVPMLKEQR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	23/92 (25%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	32/93 (34%)
LNX2	NP_699202.1	mRING-HC-C3HC3D_LNX2	45..89	CDD:319694
		modified RING-HC finger (C3HC3D-type)	50..87	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..224		7/31 (23%)
		NPXY motif	208..211		0/2 (0%)
		PDZ	230..316	CDD:214570	26/102 (25%)
		PDZ	336..422	CDD:214570	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..455		7/44 (16%)
		PDZ_signaling	466..542	CDD:238492	18/127 (14%)
		PDZ_signaling	599..683	CDD:238492	30/77 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000