Protein Alignment a and magi-1

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_001255577.1
• Gene: magi-1 / 178107
• WormBaseID: WBGene00010444
• Length: 1054
• Species: Caenorhabditis elegans
• Alignment Length: 1138
• Identity: 235/1138 - (20%)
• Similarity: 375/1138 - (32%)
• Gaps: 345/1138 - (30%)

  Fly   420 QQQQQQQQSVQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEA 484
            ::.|...|.:.|..:..|.|..||.......|||....:.:..|.|.:|...:..|.|    |.:
 Worm    25 EKLQATLQEMLDCTSSPSTSLDSTDKLPSGLAARRLIRIASEHHHISTTSSCHSDSGN----SSS 85

  Fly   485 AQQATPAATTLYRSSSTSQLSSSSYVKCDD------PTEGL---------------------NLQ 522
            ....||  .|::..:|..:|.....|:.||      |.:.|                     ::.
 Worm    86 RDVITP--FTVHGGASIGRLILIDIVRRDDLIGIVHPNDILLTIENIKVSGMVRSEVNRILEDMM 148

  Fly   523 REQRE---QRLPR----------IASLKSS----------------------------------- 539
            ||..:   :.||.          :|..|||
 Worm   149 REHDQIAIEILPAGAITDDICELLADRKSSGELQTIIRENLYQKTVPYTTRPPREGEVDGEHYRF 213

  Fly   540 -SCDDIAKV---SSCLTASTSSGSAAGS--------------LGS----PPS--SAAAGGGG--- 577
             |.||..|:   ...|...|..|...|:              :||    ||:  :|....|.
 Worm   214 VSVDDFNKLLDSGDLLENGTYQGHLYGTPRPVECYADDDMMLMGSEGLLPPNWETAYTENGDKYF 278

  Fly   578 -TANSG---------------QHDPSRRGAF-------------PYAFLRSRLSV--------LP 605
             ..|:|               |.|....|.|             ||.|..|..::        ||
 Worm   279 IDHNTGTTTWDDPRELPPGWEQVDDQNYGTFYVDHINRKTQYERPYGFGGSSATIDQPVKYGTLP 343

  Fly   606 ---EENHGNVPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRR---SPEQAMLN-NVSRNDS 663
               ..||.|:..|......:.....:....|       |||...|:   .||.|..: :...:..
 Worm   344 SSTNHNHNNIYSHYNSGTLKSSSSPRDSGFD-------SSPTRYRKFGDPPETATSSADYDHHSK 401

  Fly   664 ITSKDWEPLY----QRLSSCLSSNESGYDSDG-GATGARLGNNLS------------ISGGDTES 711
            :.|:...||:    .||...|.|.:....:.| |.|  .:||:.|            :|||  .:
 Worm   402 MFSRSSNPLFTTDPARLGGELISTKIVKGAKGLGFT--LIGNDSSSRGDEFIQVKSVLSGG--PA 462

  Fly   712 IASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSA-PVS-------LGGYNYDYE-- 766
            .|:|.|:...::         :.:...|.|||.......:..| ||:       ..||....:
 Worm   463 AANGVLRSGDIL---------VRVNGRLLLGATQKEACDVFVAIPVNEAVDIQVCRGYELFIDPA 518

  Fly   767 ----TETIRRRFRQVKLER----KCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDG 823
                ||.:....:...|..    |..|.: |.     |:..|.|.|:.:.::       ...:..
 Worm   519 NRIVTENVYAAAKSRDLHEIDIFKGSEGF-GF-----TIADNLNGQRIKKIL-------FPSQCP 570

  Fly   824 RLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQR 888
            .|..||.||.::|:::|.|..        :..||...:..|.:.....|.....|.|   ..|..
 Worm   571 NLMEGDTIVELDGRNVRPIPH--------TQLVDMLRERPIGYRGKLVVKRGSPKTR---SRTPS 624

  Fly   889 HRLSYVQ-RTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQ 952
            ....|.: :|...||.:.:..........|...||::|..:...|......:....|.:.:|..:
 Worm   625 AAFRYGEPQTNMMDSAAPLPVRSKTPAERQTSRTEEDQNVRNTLQRQPAVTSEWEGMSSAIPASR 689

  Fly   953 HRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPL-----FASGSSS------------ 1000
            .|.|||   :|....|.:..|.:..:..|...:::|...|:     ...|..|
 Worm   690 MRPSST---TLGFATPNYIPLSQYNQKPSDLITVSLIRKPVGFGFRLLGGVESKTPLSVGQIVIG 751

  Fly  1001 CSSSPNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARK-----RCSEGSAL 1060
            .::..:.||  .|.|...:.|.:....|:.:.:|.:..:.|.::..:|:.|:     ....||..
 Worm   752 GAAEEDGRL--QEGDEIVEIDGHNVEGASHSEAVVLLEAAAQNKHVKLIVRRPSRTDPARRGSLN 814

  Fly  1061 SATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPP----NSLTVGEGVAN 1121
            ||.|: ..:....|  ||.    |..:..:..:....:.|.:.......|    ..|:||:.|
 Worm   815 SAGPS-GSYDVLLH--RNE----NDGFGFVLMSSQHKNGSTVGQIQPGSPAARCGRLSVGDRV-- 870

  Fly  1122 TPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFS------------PNPYVNASSSP 1174
                .|....|:                |.:.| |.::||..            ||     ::.|
 Worm   871 ----IAVNGIDI----------------LSLSH-PDTISLIKDSGLSVRLTIAPPN-----TAGP 909

  Fly  1175 ASASTSAGAGSSLA--------------PPAAALMHHRPS-LPVAKLTIRDEEMAEVIRASMSEG 1224
            .....||..|.:..              ||:....|..|| |....|:|.|       |.||
 Worm   910 VLPMVSATLGRNFTMNGHYESNYGLPPPPPSVYEKHPPPSYLAFDGLSIND-------RMSM--- 964

  Fly  1225 SGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEING 1289
            :|.....|:.    .|.|..||||.||::.  |:|.:||..:...|.|..||.||.||::..|||
 Worm   965 NGNLIDVTLE----RGTKGFGFSIRGGQEF--GSMPLFVLRIADDGPAKADGRLQVGDQLTTING 1023

  Fly  1290 NSVQGMSHAETIGLFKNVREGTIV-LKILRRKL 1321
            .|.:||||.:.|.:   :::.|:| |.:||.:|
 Worm  1024 QSTKGMSHDDAIRI---IKQHTMVNLTVLRNRL 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	11/52 (21%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	33/85 (39%)
magi-1	NP_001255577.1	TlyC	<86..224	CDD:440865	22/139 (16%)
		NK	180..>244	CDD:450170	8/63 (13%)
		WW	263..293	CDD:238122	6/29 (21%)
		WW	294..323	CDD:197736	4/28 (14%)
		PDZ1_MAGI-1_3-like	422..509	CDD:467213	21/99 (21%)
		PDZ2_MAGI-1_3-like	534..614	CDD:467214	20/100 (20%)
		PDZ3_MAGI-1_3-like	717..801	CDD:467215	13/85 (15%)
		PDZ4_MAGI-1_3-like	822..903	CDD:467216	17/109 (16%)
		PDZ5_MAGI-1_3-like	968..1051	CDD:467217	34/91 (37%)