DRSC/TRiP Functional Genomics Resources

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Protein Alignment a and mpz-1

DIOPT Version :9

Sequence 1:NP_001014543.1 Gene:a / 43852 FlyBaseID:FBgn0000008 Length:1329 Species:Drosophila melanogaster
Sequence 2:NP_001364655.1 Gene:mpz-1 / 174657 WormBaseID:WBGene00003404 Length:2422 Species:Caenorhabditis elegans


Alignment Length:1535 Identity:294/1535 - (19%)
Similarity:477/1535 - (31%) Gaps:562/1535 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 LNKSIVSSTSISSSLPDLH--------------DKSPVMILSCTTLASNGATATAAVTATATGTA 108
            :|...:||..:::.|...|              || |:....|.|||:.     ||:.||..   
 Worm   301 INSHGMSSQQVATILRHQHPTVDMIVGRPIAYADK-PIDTPECFTLATK-----AALCATTL--- 356

  Fly   109 ATSGGSLQQQQQQHLQHQQQQQPLRTATPTCLLSGRQTPS----AISVMSLQEATSLHRQQQQPH 169
                       ::.||.|     :.|:.|:  .:..|||:    :||.:.::|    .:::::|.
 Worm   357 -----------EEALQRQ-----MATSVPS--TTANQTPNTLSPSISCVPIEE----EKEEKEPE 399

  Fly   170 QPPTIYVPVPTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSC 234
            ..||.....|.|:          .|.|   ..|..|    ::....|..|     .|.....|||
 Worm   400 PEPTTSKEQPIKI----------TTYL---PDTIDI----RKPCDCAPNY-----NRRDKRKSSC 442

  Fly   235 LYEKGSNASGGASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSLPA-TEASRNSNSSSN 298
            ...:..:..||....|:.                      .|.:.:.|.:.: .|......|.:.
 Worm   443 DDGEHGDGDGGGGCKKTK----------------------EDHQEEENEIDSKDELGEMVRSPTV 485

  Fly   299 MNGSSNSNSLDVSNSNSHSGSSTSLAS---------TTRNVFTWGKRMSRKLDLLKRSDSPAAAH 354
            ..|.|:.||:..|.|.|...:|.|:.|         ....||......|.|.:|:     ..|.|
 Worm   486 ETGQSDENSVVTSVSRSSKRNSNSITSRISLKSLQEMALTVFLRENWESTKFELI-----DVALH 545

  Fly   355 KSHS-DLRSLFHSPTHHKSGSGGSSGPSSAKASASPTGG-----------------HQNSSGSTT 401
            :..: .|........|.|...||....|....||:.:.|                 |.:.:.|..
 Worm   546 RDPALGLGITVAGYVHKKEEIGGIFVKSLVPRSAASSSGVIKVHDLILEVNGTTLEHMSHADSVR 610

  Fly   402 STLK-----KCK------SGP-IETIKQRHQQQQQQQ---------------------------- 426
            :.:|     |.|      |.| .:.:|...||:.:.|                            
 Worm   611 TLVKSGDQVKLKLVRFPLSSPQAQCLKMLQQQETETQVIDVKLSNPDLVKEWKSRIGDDIEIIAA 675

  Fly   427 ------QSVQDVGTGQS--------QSAQSTPTHQFQAAARPQKALKNFFHRIGSTGM-LNH--- 473
                  ||| |.|.|.|        ..||..|.|..::..:.....|....:.|...: :||   
 Worm   676 VVKPDRQSV-DGGLGISLEGTVDVLNGAQLCPHHYIESIRQDGPVAKTKVLQAGDELLQVNHSPL 739

  Fly   474 --RSHNLLK--ASEAAQQATPAATTLYRSSS----------TSQL---------SSSSYVKCDDP 515
              .||..::  .:.|.....|....:.|.|.          ..||         :..:.||....
 Worm   740 YGESHVTVRQALTRAVHSGAPVTLIVARRSQHLHVFEPTTYEKQLPLSFPFLAANQETVVKAKSD 804

  Fly   516 TEGLNLQREQREQRLPRIA-SLKSSSCDDI--AKVSSCLTA-------STSSGSAAGSLGSPP-- 568
            .: |...|.:....|.|:: .|:|.|.::.  ..|.:|:..       |...|.:......|.  
 Worm   805 ID-LTSTRAETTHLLQRVSRRLRSKSLENFHGLAVWNCVPLVIHLCKDSRGLGFSIVDYKDPTHR 868

  Fly   569 -------SSAAAGGGGTANS-----------GQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGH 615
                   .|...||...|:.           ..||.|.      :.|...::||.....|.|...
 Worm   869 DESVIVVQSLVPGGVAQADGRVVPGDRLLFVNNHDLSN------SSLERAVAVLKAARMGPVRLG 927

  Fly   616 LKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQR--LSS 678
            |.:.|...:.|...|           |||             .||::.:.::...|..:|  .|.
 Worm   928 LAKPIPVDQSQFTSH-----------SPL-------------CSRSERLLARGRSPRGRRRYTSG 968

  Fly   679 CLSSNES---------------GYDSDGGATGARLGNNLSISGGDTESIASGTLKRNSLISLSSS 728
            ..||.|:               ||......:.||  :..||.|.:.           |:.|.|..
 Worm   969 TTSSQETVWIGTAEQYRKLHPQGYYPSRSPSAAR--SERSIEGSEF-----------SMTSWSPC 1020

  Fly   729 EGVGMGMGMSLGLGAPSTRNSSICSAPVSL-GGYNYDYETETIRRRFRQVKLER--KCQEDYIGI 790
                            |||:.|.|.:|:|| |.:.||..       |....|||  |.|:.    
 Worm  1021 ----------------STRSVSPCGSPISLRGSWAYDVV-------FLPTHLERTVKLQKG---- 1058

  Fly   791 VLSPKTVMTNSNEQQYRYLIVELEPYGMAQK-----DGRLRLGDEIVNVNGKHLRGI---QSFAE 847
            .|....|:....::.....:|:    .:..|     |||:::||.|..:|.:.||.:   |:.|.
 Worm  1059 ALPLGAVLDGDKDKGVNGCVVK----SICGKKAVALDGRIQVGDFITKINTESLRNVTNSQARAI 1119

  Fly   848 VQR--LLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQR---------HRLSYVQRTQS-- 899
            ::|  |:.:|.:  :..:.:.|..|....|............|         :|..::||.:|  
 Worm  1120 LKRTNLVGTFCN--VTYITSADAKTWKERFQRPSESSSPIINRLSPKVFPKFYRSPFMQRQESQS 1182

  Fly   900 ---------------TDSLSS-MQSLQLQQERIQGHNTEQE------------------------ 924
                           |||:|. :::..|.:...:.|:.|||                        
 Worm  1183 KTEMTDDETEAPSIMTDSMSEHIKTFDLAEGSSRSHHDEQEVRNRMSRLIDGVEVDDFVNLIIKE 1247

  Fly   925 ------------QEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAPE----HELL 973
                        .:.:....|:.:....:.:.|.|.| .....||.|:..:....|.    .|:|
 Worm  1248 AITDATIELRVLHKTKDWSNCNHKREERLESPPLPPP-PPEVLSSPPKSPVASVQPTPRDLEEVL 1311

  Fly   974 RRRARSS----SGQRSL----------ALTPTPLFASGSSSCSSSPNHRLLDNENDPANDTDSYT 1024
            .|...||    ||||:.          .|..||         .|||       ||..:....|.:
 Worm  1312 TRSTASSLEYHSGQRTSQLHILSTEEEVLQATP---------PSSP-------ENKSSEVPPSIS 1360

  Fly  1025 PVYANRAASVCVASSLADDEKWQLLAR--------KRCSEGSALSATPNPQQFGQRTHYARNSIN 1081
            |      :.:.:|..:...|:.:::..        :..:.|:.:.||..|               
 Worm  1361 P------SGIKLAGEVTAPEEIEVVKEQAENVDRAETAATGAEVEATSTP--------------- 1404

  Fly  1082 LANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQT 1146
                                             ..|.:.|:....:|||: ::.|....|.|   
 Worm  1405 ---------------------------------TAEAIGNSKDDESTTTS-ISQQSVGLQTQ--- 1432

  Fly  1147 HQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDE 1211
                         :|.|..  ||::.|..::.|.:....||...|..|             :|.:
 Worm  1433 -------------ALNSTE--VNSNMSRVTSRTPSTGSESLQNQARQL-------------VRSK 1469

  Fly  1212 EMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGR--DSPKGNM--------GIFVKTV 1266
            ...|.              :|:|..:.|. ||.|.||||||  .|.||.:        |||:|:|
 Worm  1470 YWGEA--------------RTVTLVREPN-KSFGISIVGGRVEVSQKGGLPGTGNTVCGIFIKSV 1519

  Fly  1267 FPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKN 1306
            .|:..|...|.:..||.::.:|...::..:|.:.:...||
 Worm  1520 LPNSPAGRSGQMNMGDRVISVNDVDLRDATHEQAVNAIKN 1559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aNP_001014543.1 PDZ_signaling 775..865 CDD:238492 23/101 (23%)
PDZ_signaling 1230..1317 CDD:238492 29/87 (33%)
mpz-1NP_001364655.1 PDZ_signaling <271..326 CDD:238492 5/24 (21%)
PDZ_signaling 539..624 CDD:238492 17/89 (19%)
PDZ_signaling 685..766 CDD:238492 16/80 (20%)
PDZ_signaling 843..926 CDD:238492 15/88 (17%)
PDZ 1050..1124 CDD:214570 20/81 (25%)
PDZ_signaling 1475..1569 CDD:238492 29/86 (34%)
PDZ 1827..1912 CDD:214570
PDZ 1988..2073 CDD:214570
PDZ_signaling 2089..2169 CDD:238492
PDZ_signaling 2341..2414 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19964
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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