Protein Alignment a and Lnx1

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_001153049.1
• Gene: Lnx1 / 16924
• MGIID: 1278335
• Length: 728
• Species: Mus musculus
• Alignment Length: 813
• Identity: 149/813 - (18%)
• Similarity: 250/813 - (30%)
• Gaps: 317/813 - (38%)

  Fly   615 HLKQQIQRQREQHQ--------QH---QRDLLQQEQTSSP------LPQRRSPEQAMLNNVSRND 662
            |..:.:||...||.        .|   .:|..::.|...|      :....|||.:....:|
Mouse   114 HCTEVLQRCDLQHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATIS--- 175

  Fly   663 SITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGN---NLSISGGDTESIASGTLKRNSLIS 724
                             |.::|.|.|:....:....|.   |.|.||....:.|. ..:|:::.|
Mouse   176 -----------------LMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSNRTRAR-PFERSTMRS 222

  Fly   725 LSSSEGVGMGMGMSLGLGA-PSTRNSSICSAPVSLGGYNYDYET--ETIRRRFR--------QVK 778
            .|..:       ::..|.| ..|::.|:.:..|..|..|.:..|  |...|.|.        .:|
Mouse   223 RSFKK-------INRALSALRRTKSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIK 280

  Fly   779 LERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVE-LEPYGMAQKDGRLRLGDEIVNVNGKHLRGI 842
            :.|....:.:.|.|      ...:|....::|:: :...|:..:||||..||.|:.|||.
Mouse   281 INRADPSESLSIRL------VGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM----- 334

  Fly   843 QSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQSTDSLSSMQ 907
                                     :::.|...|. :|:.....|..||:.
Mouse   335 -------------------------DISNVPHNYA-VRLLRQPCQVLRLTV-------------- 359

  Fly   908 SLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTP------------- 959
               |::::.:..:.....::.|........:.:.|:....:.:...||...|
Mouse   360 ---LREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVA 421

  Fly   960 ----------------RHSLDVGAPE-------------HELLRRRARSSS------------GQ 983
                            .|.|..|:||             |.::.|:.|.||            ||
Mouse   422 DRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDIFQEAGWISNGQ 486

  Fly   984 RSLALTPTPLFASGSSSCSSSP----NHRLLDNENDP-----------ANDTDSYTPVYANRAAS 1033
            :|    |.|    |..:.:|.|    :.:::....||           |:..:...|:|   ..|
Mouse   487 QS----PGP----GERNTASKPAATCHEKVVSVWKDPSESLGMTVGGGASHREWDLPIY---VIS 540

  Fly  1034 VCVASSLADDEKWQLLARK-RCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHSRL 1097
            |         |...:::|. |...|..|...              |.|.|
Mouse   541 V---------EPGGVISRDGRIKTGDILLNV--------------NGIEL--------------- 567

  Fly  1098 SSSRLSLFMQAPPNSLTVGEGVA---NTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSV 1159
                         ..::..|.||   :.|||......::..|:.|:
Mouse   568 -------------TEVSRTEAVAILKSAPSSVVLKALEVKEQEAQE------------------- 600

  Fly  1160 SLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPS------LPVAKLTIRDEEMAEVIR 1218
                       ..|||:..::    .::.||.    ...||      ||......:|     ||.
Mouse   601 -----------DCSPAALDSN----HNVTPPG----DWSPSWVMWLELPQYLCNCKD-----VIL 641

  Fly  1219 ASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDE 1283
            ...:.|                  ||||.||||.:...||...|:|::.....|.:||.::.||.
Mouse   642 RRNTAG------------------SLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDI 688

  Fly  1284 IVEINGNSVQGMSHAETIGLFKNVREGTIVLKI 1316
            ::.:||.|..||.||....:.|.:: |.|.|.|
Mouse   689 LLAVNGRSTSGMIHACLARMLKELK-GRITLTI 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	11/52 (21%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	28/84 (33%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:438435
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..220		7/35 (20%)
		NPXY motif	185..188		0/2 (0%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		13/65 (20%)
		PDZ1_LNX1_2-like	274..362	CDD:467165	24/141 (17%)
		PDZ2_LNX1_2-like	384..466	CDD:467166	10/81 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..500		7/26 (27%)
		PDZ3_LNX1_2-like	507..592	CDD:467167	21/138 (15%)
		PDZ4_LNX1_2-like	637..725	CDD:467168	33/108 (31%)