Protein Alignment a and FRMPD2

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_054220869.1
• Gene: FRMPD2 / 143162
• HGNCID: 28572
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 935
• Identity: 175/935 - (18%)
• Similarity: 319/935 - (34%)
• Gaps: 296/935 - (31%)

  Fly   616 LKQQIQRQREQHQQHQRDLLQQ--EQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRL-- 676
            :::::..:....||::..||::  ..|||..|..::||......||...:.|....||.:..|
Human   190 VEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTH 254

  Fly   677 SSC-LSSNES--GYDSDGGATGARLGNNLSISGGD----TESIASGTLKRNSLIS-----LSSSE 729
            |.| |..|.:  |.|......|.||.:....|..|    |.....|.|:|.|..|     |.:.|
Human   255 SHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGE 319

  Fly   730 GVGMGMGMSLGL-GAPSTRNS-------SICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQ-E 785
            .     .|:|.| |:..|:..       .:|  .|.|.|.:                ||.||. |
Human   320 A-----PMTLHLPGSVVTKKGKSYLALRDLC--VVLLNGQH----------------LEVKCDVE 361

  Fly   786 DYIGIVLSPKTVMTNSNEQQY---RYL-------------IVELEPYGMAQKDGRLRLGDEIVNV 834
            ..:|.|.:..|...|..|..|   .|:             :.::.|.|..::..:..:     |.
Human   362 STVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSM-----NT 421

  Fly   835 NGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQS 899
            ....|| |:.|.....||...:              |...||.::|.|.:..:.:        .:
Human   422 FTLFLR-IKFFVSHYGLLQHSL--------------TRHQFYLQLRKDILEERLY--------CN 463

  Fly   900 TDSLSSMQSLQLQQERIQGHNTEQEQEAQG----EDQCDARSMASVSTMPTPMPLMQ-HRRSST- 958
            .:.|..:..|.||.|  .|:..:::.|::.    ||...|..:..::.:...:.:.: ||.||.
Human   464 EEILLQLGVLALQAE--FGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSAL 526

  Fly   959 ----------------PRHSL-------DVGAPEHELL--------------------------R 974
                            |.:.:       :...||.|:.                          |
Human   527 WGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWR 591

  Fly   975 RRARSSSGQRSLALTPT-----PLFASGSSS--------CSS-----------SPNHRLLDNEN- 1014
            ...:.|:.|:...:|.:     ..|.:.|:.        ||:           .|:|.|.|::.
Human   592 ETGKISTYQKKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKF 656

  Fly  1015 -DPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSAT-----------PNPQ 1067
             ..||    .:|.:..|:..:.....|:..|....::|.:.:.|..||.:           ...:
Human   657 VQMAN----LSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAE 717

  Fly  1068 QFGQRTHYARNSI-------------NLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSL------ 1113
            ..|:.....|..:             :|:....:|:   |:...::|...|:..|...:
Human   718 GIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSM---HAGSKNNRRKSFIAEPGREIVRVTLK 779

  Fly  1114 ---------TVGEG---------------VANTPSSTATTTTDLTNQQQQQQNQQQTHQSL---- 1150
                     .:.||               :...|:..|.|.      :...|.....|.||
Human   780 RDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTI------KPGGQILALNHISLEGFT 838

  Fly  1151 ------YIKHSPKSVSLF----------SPNPYVNASSSPASAST---SAGAGSSLAPPAAALMH 1196
                  .|::||.::.|.          :|:...|::::...:||   |.|...||.........
Human   839 FNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDR 903

  Fly  1197 HRPSLPVAKLTIRDEEMAEVIRASMS----EGSGRCTPKT-----------ITFFKGPGLKSLGF 1246
            :...|.:|.:    :.:...:|..:|    :|:|...|.:           :...|..|  :|||
Human   904 NTEELDMAGV----QSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDG--TLGF 962

  Fly  1247 SIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGT 1311
            |:.||.::.....||:||::.|.|.||.:|.:..||.:::::|..:.|::|.:.:...|.  .|.
Human   963 SVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLKG--PGQ 1025

  Fly  1312 IVLKILRRKLQKA--------KSMG 1328
            :...:|.|::.::        .|||
Human  1026 VARLVLERRVPRSTQQCPSANDSMG 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	9/52 (17%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	24/95 (25%)
FRMPD2	XP_054220869.1	KIND	15..197	CDD:214801	0/6 (0%)
		FERM_F1_FRMPD2	341..434	CDD:340716	23/116 (20%)
		B41	346..550	CDD:214604	44/249 (18%)
		FERM_C_PTPH13	546..647	CDD:270008	11/100 (11%)
		PDZ_canonical	772..863	CDD:483948	13/96 (14%)
		PDZ2-PTPN13_FRMPD2-like	947..1033	CDD:467254	25/89 (28%)
		PDZ3_PTPN13_FRMPD2-like	1078..1166	CDD:467181