DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and Lnx2

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	633	Identity:	138/633 - (21%)
Similarity:	205/633 - (32%)	Gaps:	214/633 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 PSTRNSSICSAPV---SLGGYNYDYETETIRRRFRQ-----------VKLERKCQEDYIGIVLSP 794
            |..||.:..|.||   ..|..|..:|........:|           :::.|  ...||.:.:|
Mouse   186 PGERNLTPASLPVWTEEPGLDNPAFEESAAADSVQQPLSLPEGEITTIEIHR--SNPYIQLGIS- 247

  Fly   795 KTVMTNSNEQQYRYLIVELEPY--GMAQKDGRLRLGDEIVNVNG--------KHLRGI--QSFAE 847
               :...||.....:::: |.|  |:..:||||..||:|:.||.        .|.|.:  |..:.
Mouse   248 ---IVGGNETPLINIVIQ-EVYRDGVIARDGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCST 308

  Fly   848 VQ------RLLSSFVDNCIDLVIAHDEVTTV----TDFYTKIRIDGMSTQRHRLSYVQRTQSTDS 902
            :|      |...|..::..|.....|||..|    .|          ||::..:..|:||..
Mouse   309 LQLTVLRERRFGSRANSHADGSAPRDEVFQVLLHKRD----------STEQLGIKLVRRTDE--- 360

  Fly   903 LSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGA 967
             ..:..|.|    ::|....|:......|                      |..:...|.|..|.
Mouse   361 -PGVFILDL----LEGGLAAQDGRLNSND----------------------RVLAINGHDLKHGT 398

  Fly   968 PEHELLRRRARSSSGQR-SLALT----PTPLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVY 1027
            ||   |..:...:||:| :|.:.    |.|...|..:...||.||....:.:.|.:..|
Mouse   399 PE---LAAQIIQASGERVNLTIARPGKPQPSNGSREAGAHSSSNHAQPPSHSRPGSHKD------ 454

  Fly  1028 ANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRF 1092
                .:.||.                |.|..........:..|......|.|
Mouse   455 ----LTRCVT----------------CQEKHITVKKEPHESLGMTVAGGRGS------------- 486

  Fly  1093 AHSRLSSSRLSLFM-QAPPN------------------------SLTVGEGVANTPSSTATTTTD 1132
                 .|..|.:|: ..||:                        :|:..|.||...:|.|:....
Mouse   487 -----KSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVI 546

  Fly  1133 LTNQQQQ--QQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALM 1195
            |...:.|  ::..|.|.:         ..|.||.|.| :||.||:....       |..|:|  :
Mouse   547 LKALEVQIAEEAAQATEE---------QPSAFSENEY-DASWSPSWVMW-------LGLPSA--L 592

  Fly  1196 HHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMG 1260
            |....:              |:|.|.                   |.|.|||||||.:....|..
Mouse   593 HSCHDI--------------VLRRSY-------------------LGSWGFSIVGGYEENHTNQP 624

  Fly  1261 IFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVR 1308
            .|:||:.....|..||.|:.||.||.:||.|..||||:..:.:.|..|
Mouse   625 FFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	26/118 (22%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	30/79 (38%)
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175
		NPXY motif	207..210		1/2 (50%)
		PDZ	229..315	CDD:214570	22/92 (24%)
		PDZ_signaling	336..418	CDD:238492	24/124 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		8/36 (22%)
		PDZ_signaling	463..539	CDD:238492	13/93 (14%)
		PDZ_signaling	596..680	CDD:238492	33/110 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000