DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Il16

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_006229550.1	Gene:	Il16 / 116996	RGDID:	1583872	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	1415	Identity:	260/1415 - (18%)
Similarity:	434/1415 - (30%)	Gaps:	556/1415 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 HKSNSLPA---TEASRNSNSSSNMNGSSNSNSLDVSNSNSHSG---SSTSLASTTRNVFTWGKRM 337
            |.:.:.|:   |...|.........|.::|..::   .:||||   .||...|.:|::.
  Rat    71 HAAAAKPSSSTTHRPRPGEQERKKRGLTSSLRME---PHSHSGKSRKSTKFRSISRSLI------ 126

  Fly   338 SRKLDLLKRSDSPAAAHKSH---------SDLRSLFHSPTH--HKSGSGGSSGPSSAKASASPTG 391
               |...|.||..::..:.:         .|....|||...  ..|.:|.|:.|..|.||.:
  Rat   127 ---LCNAKTSDDSSSPDEKYPDPFETSLCQDKEGFFHSSMQLADTSEAGLSNIPDLALASEA--- 185

  Fly   392 GHQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQDVGTGQSQSAQSTPTHQFQAAARPQK 456
            ....::||...  |.|:       |....::.....|.:..|..::||:    ...|..|...:.
  Rat   186 AQLQAAGSDRG--KHCR-------KMFFLKESSTTSSKEKAGKSEAQSS----NFLFPKACHQRT 237

  Fly   457 ALKNFFHRIGSTGMLNHRSHN----LLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTE 517
                   |..||.:..:.:..    :.|.|.|.....|.:....|.|.:.||        |.|..
  Rat   238 -------RSNSTSVNPYSAREMDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL--------DYPVS 287

  Fly   518 GLNLQREQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSG--------------------SAAG 562
            |             .....:|.|...:.::|..|.||..|.                    |..|
  Rat   288 G-------------TARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 339

  Fly   563 SLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQH 627
            .:|....|..|||...|:....:...               :.|.|..::.|...|...::.:|.
  Rat   340 PIGIYVKSIFAGGAAAADGRLQEGDE---------------ILELNGESIAGLTHQDALQKFKQA 389

  Fly   628 QQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSS--CLSSNESGYDSD 690
            ::....|..:.:.::|                  .|:.|....||.:.|||  |.:.:.|.:..:
  Rat   390 KKGLLTLTVRTRLTTP------------------PSLCSHLSPPLCRSLSSSTCGAQDSSPFSLE 436

  Fly   691 GGATGARLGNNLSISGGDTESIASGTLKRNSLI----SLSSSEGVGMGMGMSLGLGAPSTRNSSI 751
            ..|:.|                  .|.|.|..|    ||....|||:|:|              :
  Rat   437 SPASPA------------------STAKPNYRIMVEVSLKKEAGVGLGIG--------------L 469

  Fly   752 CSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPY 816
            ||.|.                 |:.:.          |:                  .|..|.|.
  Rat   470 CSIPY-----------------FQCIS----------GV------------------FIHTLSPG 489

  Fly   817 GMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTK--- 878
            .:|..|||||.|||||.:|...:. ..:..||..:||......:.::::......|::...|
  Rat   490 SVAHLDGRLRCGDEIVEINDSPVH-CMTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAV 553

  Fly   879 -IRIDGM--STQRHR--LSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQ---------- 928
             ..::|:  ..:||:  |..|:|.:|  |.....:|:.::|:   |:....:.||
  Rat   554 AQAVEGVKFGKERHQWSLEGVKRLES--SWHGRPTLEKEREK---HSAPPHRRAQKIMVRSSSDS 613

  Fly   929 ----------------------------------GEDQCDARSMAS------------------- 940
                                              ||:|.....:.|
  Rat   614 SYMSGSPGGSPCSAGAELQPSEGEGSTHSPSLPPGEEQEPCPGVPSRPHQESPPLSESLERDSHP 678

  Fly   941 ---------------VSTMPTPMPLMQHRRSSTPR--------------HSLDVGAPE-HELLRR 975
                           .||.|.|.|....:..|.|:              |:|...:.| .|||..
  Rat   679 PLKLKNSFEILVRKPTSTKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETRELLPL 743

  Fly   976 RARSSSGQRSL---ALTPTPLFASGSSSC-------SSSP-------NHRLLDNE---------- 1013
            ..:..:..|:|   |..|.|..::.:||.       |:||       .|.||..:
  Rat   744 LLQEDTAGRTLCTAACCPGPAASTQTSSSTEGEPRRSASPETPASPGKHPLLKRQARMDYSFDST 808

  Fly  1014 -NDP---------------ANDTDSYTPVYANRA------------------------------- 1031
             .||               .::..|:.|:..|.:
  Rat   809 TEDPWVRISDCIKNLFSPIMSENHSHMPLQPNASLGEEDGTQGHPEGGLSKMDTANGAPRIFKSA 873

  Fly  1032 --ASVCVASSLADDEKW--QLL--ARKRCSE-------GSALSATP-NPQQFGQRTHYARNSINL 1082
              ::|.....:|....|  |.|  .|.|..|       .||:..|| :....|.::..:.:||..
  Rat   874 DGSTVKKGPPVAPKPAWFRQSLKGLRNRVPETRRAPEVASAIQTTPVSRDASGPQSQASSSSIRQ 938

  Fly  1083 ANSHYRSLRFAHSRLSS---SRLSL------------------FMQAP----------------- 1109
            ..|.:.:  |..|:|..   .||||                  |...|
  Rat   939 RISSFEN--FGSSQLPDRGVQRLSLQPTSGETTRLPGKQDEGRFSGLPAQGTKVTAKHRQTEVEP 1001

  Fly  1110 -----PNSLTVGE---------GVANTPSSTA--------TTTTDLTN-------QQQQQQ---N 1142
                 |||..||:         |....|.:.:        ||.|:.|.       .|:.:.   .
  Rat  1002 PSTTFPNSSEVGDPDMSESPPPGQRPNPKALSPDPLLRLLTTQTEDTQGPGFKMPSQRARSFPLT 1066

  Fly  1143 QQQTHQSLYIKHSPKSVSLFSPNPYVNAS---------------------------SSPASASTS 1180
            :.|::::..:  ..||..|:|.:..::::                           .||.:.|.:
  Rat  1067 RTQSYETKLL--DEKSSKLYSISSQLSSAVMKSLLCLPSSASCGQITCIPKERVSPKSPCNNSAA 1129

  Fly  1181 A-GAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPK----TITFFKGPG 1240
            | |.|.::|.....      ||.:::|....|.:.|   ...:|....|:.:    .|:......
  Rat  1130 AEGFGEAVASDTGF------SLNLSELREYSEGLTE---PGETEDRNHCSSQAGQSVISLLSAEE 1185

  Fly  1241 LK-------------------------------SLGFSIVGGRDSPKGNMGIFVKTVFPSGQAAD 1274
            ||                               .||||:.||.|..  |..|.|..|||:|.|:.
  Rat  1186 LKKLIEEVRVLDEATLKQLDSIHVTVLHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQ 1248

  Fly  1275 DGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKLQKA 1324
            :||:|.|:|::.|||.|::|.:|.:.:.:.:..|:....:.:.|:.:.:|
  Rat  1249 EGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQAVIVTRKAIVEA 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	20/89 (22%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	30/121 (25%)
Il16	XP_006229550.1	PDZ_signaling	316..391	CDD:238492	13/89 (15%)
		PDZ_signaling	454..536	CDD:238492	31/141 (22%)
		PDZ_signaling	1207..1284	CDD:238492	27/78 (35%)
		PDZ	1329..1413	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7902
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46076
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.860