DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment a and PATJ

DIOPT Version :9

Sequence 1:NP_001014543.1 Gene:a / 43852 FlyBaseID:FBgn0000008 Length:1329 Species:Drosophila melanogaster
Sequence 2:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens


Alignment Length:1534 Identity:301/1534 - (19%)
Similarity:477/1534 - (31%) Gaps:552/1534 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 VPVPT-KLGNNVNT--GNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYE 237
            :|:.| :||..|::  |:...:.::|.|...::..||.:.:             |...:...||.
Human   563 LPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDE-------------LLEVNGMQLYG 614

  Fly   238 KGSNASGGASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDE-------HKSNSLPATEASRNSNS 295
            |....:      .|.|...|    |.:.||....  :.|||       ....|||.||...|   
Human   615 KSRREA------VSFLKEVP----PPFTLVCCRR--LFDDEASVDEPRRTETSLPETEVDHN--- 664

  Fly   296 SSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTRNVFTWGKRMSRKLDLLKRS----------DSP 350
                        :||:......|          .:..|...: :.::|:|..          ..|
Human   665 ------------MDVNTEEDDDG----------ELALWSPEV-KIVELVKDCKGLGFSILDYQDP 706

  Fly   351 AAAHKSHSDLRSLFHSPTHHKSGS---GGS---------SGPSSAKA----SASPTG----G--- 392
            ....:|...:|||.......:||.   |..         ...|.|:|    .|.|.|    |   
Human   707 LDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICK 771

  Fly   393 --------------HQNSSGSTTSTLKKCKSGPIETI---------------------------- 415
                          |.:|:...|..     ||.|..|                            
Human   772 PLVEDNEEESCYILHSSSNEDKTEF-----SGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFL 831

  Fly   416 ---KQRHQQQQQQQQS-------------VQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHR 464
               |..|.||::.:||             :|::    .:..:.....:::....|..:::.:   
Human   832 DLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEM----DEEREILVDEEYELYQDPSPSMELY--- 889

  Fly   465 IGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQRE-- 527
                 .|:|           .|:|||..:.......|..|..:...:..:...|..:..::.:  
Human   890 -----PLSH-----------IQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPY 938

  Fly   528 --------------QRLPRIASLKSSS----CDDIAKVSSCLTASTSSGSAAGSLGSP------P 568
                          :.||.:.|.:.:|    .||:..::|....|...|.....:..|      |
Human   939 GYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLP 1003

  Fly   569 SSAAAGGGGTANSGQHDPSR---RGAFPYAFLRSRLSV----LPEENHGNVPGHLKQQIQRQREQ 626
            ..|...........||..:|   :.:.....|.||.:.    |||...|                
Human  1004 VVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEG---------------- 1052

  Fly   627 HQQHQRDLLQQEQT---SSPLPQR-----RSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSN 683
                     :.|:|   |...|.|     |.|      |||...||..  .:.:.:||.:  ...
Human  1053 ---------EGEETPNFSHWGPPRIVEIFREP------NVSLGISIVG--GQTVIKRLKN--GEE 1098

  Fly   684 ESGY-------DSDGGATGA-RLGNN-LSISGGD----TESIASGTLKR--NSLI----SLSSSE 729
            ..|.       ||..|.|.| :.|:. |.:||.|    :.|.|...:|.  |.::    ||||:.
Human  1099 LKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163

  Fly   730 GVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYD------------------------------ 764
            .|           .|:..|    .|....|..|.|                              
Human  1164 RV-----------IPNVHN----KANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSD 1213

  Fly   765 -------YETETIRRRFRQVKLER---KCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMA 819
                   :..:.||:|:..:..|.   :.::|..|:.||   :..|.:..:....:|.:.|.|.|
Human  1214 ENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLS---LAGNKDRSRMSIFVVGINPEGPA 1275

  Fly   820 QKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGM 884
            ..|||:|:|||::.:|.:.|.| :|......::.: ..:.:.||...:|     |...::.:...
Human  1276 AADGRMRIGDELLEINNQILYG-RSHQNASAIIKT-APSKVKLVFIRNE-----DAVNQMAVTPF 1333

  Fly   885 STQRHRLSYVQRTQSTDSLSS---------------MQSLQLQ-QERIQGHNTEQEQEAQGEDQC 933
            .......|.::....|:.:||               .:|.:|: ..::.|.....:|:...|...
Human  1334 PVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLEDMSQVIGQGMVADQQKALEYPP 1398

  Fly   934 D-ARSMASVSTMPTPMPLMQHRRSSTPR---HSLDVG--------------------APEHELLR 974
            | |.|.......||.:..........|.   ||.|..                    .|..|:: 
Human  1399 DNAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI- 1462

  Fly   975 RRARSSSGQRSLALT-----PTPLF-ASGSSSCSSSP-------NHRLLDNENDPANDTDSYTPV 1026
              ...|.|:..|.|:     .|||| ..||....|..       :|.:.:.|...|.....   |
Human  1463 --IEISKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQNAIVIHE---V 1522

  Fly  1027 YANRAASVCVASSLADDEKW---QLL------ARKRCSEGSALSATPNPQQ-----FGQRTHYAR 1077
            |...||:       .|...|   |:|      .|....|.:..:....||:     :....||..
Human  1523 YEEGAAA-------RDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRD 1580

  Fly  1078 NS------INLANSHYRSLR------------FAHSRLSSSRLSL---FMQAPPNSLTVGEGVAN 1121
            ..      ::|.....|.|.            |....:......|   .:|........||.:.|
Human  1581 EENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRN 1645

  Fly  1122 TPSSTATT---------------------TTDLTNQQQQQQNQQQTHQSLYIKHSP--------- 1156
            ....|..|                     |:..|..|..|.:||..|.|.:...:|         
Human  1646 ASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLV 1710

  Fly  1157 --KSVSLFSPNP------------YVNASSSPA-SASTSAGAGSSLA--PPAAALMHHRPSLPVA 1204
              |.||  .|:.            .:|...|.| ..|.:.|.||.|.  |...|::.   :..||
Human  1711 GTKRVS--DPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQ---ASGVA 1770

  Fly  1205 ----KLTIRDE------------EMAEVIR--------------------------ASMSEG--S 1225
                ||.:.|.            ..|:|:.                          .:||.|  .
Human  1771 ARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHL 1835

  Fly  1226 GRCT------------PKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTL 1278
            |..|            ||.||..||.  :.||||||||..||.|::.|:|||||..|.|||||.|
Human  1836 GSPTAEHHPEDTETPPPKIITLEKGS--EGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAADDGRL 1898

  Fly  1279 QAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            :.||:|:.:||.:::|::|.:.:.:.|:.| ||:.|.:|
Human  1899 KRGDQILAVNGETLEGVTHEQAVAILKHQR-GTVTLTVL 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aNP_001014543.1 PDZ_signaling 775..865 CDD:238492 23/92 (25%)
PDZ_signaling 1230..1317 CDD:238492 42/86 (49%)
PATJXP_011538764.1 L27_2 8..65 CDD:117611
PDZ_signaling 135..218 CDD:238492
PDZ_signaling 246..325 CDD:238492
PDZ_signaling 366..450 CDD:238492
PDZ_signaling 570..634 CDD:238492 16/86 (19%)
PDZ 683..772 CDD:214570 17/89 (19%)
PDZ_signaling 1066..1157 CDD:238492 25/100 (25%)
PDZ 1236..1321 CDD:214570 23/89 (26%)
PDZ 1459..1574 CDD:214570 27/127 (21%)
PDZ_signaling 1586..1666 CDD:238492 11/79 (14%)
PDZ_signaling 1729..1814 CDD:238492 17/87 (20%)
PDZ_signaling 1852..1936 CDD:238492 42/86 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19964
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.000

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