DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and cytip

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_003199223.2	Gene:	cytip / 100537036	ZFINID:	ZDB-GENE-140106-76	Length:	343	Species:	Danio rerio

Alignment Length:	195	Identity:	48/195 - (24%)
Similarity:	78/195 - (40%)	Gaps:	40/195 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1143 QQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSL----PV 1203
            |..:..|..|..|.|..|:....   .:.|||.:.:|....|.:|:....|..|....:    |.
Zfish    14 QMSSLDSYIIDSSQKKRSILWRQ---RSFSSPKNLNTEGMKGRTLSQSQLARTHSNSLVDYTDPQ 75

  Fly  1204 AKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFP 1268
            ..:.:.:::..||....:.           |:    |||....|:|        .|..||..| .
Zfish    76 RTMVVLEKQDNEVFGFEVQ-----------TY----GLKVKNTSMV--------EMCTFVCRV-Q 116

  Fly  1269 SGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKI------LRRKLQKAKSM 1327
            .|.||:...|.|||.|:.:||.|::|.:|...|.|   :||.:..||:      :.::::..|.|
Zfish   117 DGSAAETAGLTAGDIILSVNGVSIEGSTHQNIIEL---IRESSNTLKLETVSGSVMKRIELEKKM 178

Fly 1328 1327
Zfish 179 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	29/92 (32%)
cytip	XP_003199223.2	PDZ_signaling	78..162	CDD:238492	31/110 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900