Protein Alignment a and il16

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_021333386.2
• Gene: il16 / 100534674
• ZFINID: ZDB-GENE-130103-3
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1348
• Identity: 269/1348 - (19%)
• Similarity: 445/1348 - (33%)
• Gaps: 411/1348 - (30%)

  Fly   160 SLHRQQQQPHQPPTIYVPVPTKLGNNVNTGNSSATLLLSYGSTSS--IANLQQQQQQHAAQYQQY 222
            ||.:|.:.||..|...|.....|        |||.|:.|..|..:  |:|:
Zfish   308 SLSQQLEFPHSVPQAVVRPSRSL--------SSAHLVPSCSSVQAFIISNI-------------- 350

  Fly   223 VAQRLHAASSSCLYEKGSNAS--GGASSNKSSL-----SLTPNG-HLPDYKLVTAMPVVVLDDE- 278
            |..:.|.        ||...|  ||..|....:     ::.|.| ...|.:|.....::.|:.|
Zfish   351 VLMKGHG--------KGLGFSIVGGRDSMYGPMGIYVKTIFPGGAAAADGRLQEGDEILELNGES 407

  Fly   279 ----------HKSNSLP---ATEASRNSNSSSNMNGSSNSNSLDVSNSNSHSGSSTSLASTTRNV 330
                      ||...:.   .|...|.|.....:.||....| .:..|.|.| |||:::
Zfish   408 LHGLTHEDALHKFKQVKKGLLTLVVRTSLRVGAVMGSHGQAS-QLCRSRSLS-SSTAIS------ 464

  Fly   331 FTWGKRMSRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTHHKSGSGGSSG----PSSAKASASPTG 391
                 |:|..|......::||.|..     |.:.....|.:.|.|...|    |||        |
Zfish   465 -----RVSADLGEYNCLNNPAKAQD-----RVMMEITLHKEFGVGLGIGLCCVPSS--------G 511

  Fly   392 G------HQNSSGSTT-----------------------------STLKKCKSGPIETIKQRHQQ 421
            |      |..|.||..                             :.|.:|..||:..|..||..
Zfish   512 GCPGIYIHTLSPGSVAHMDGRLRCGDEIMEINETVVCNMTLNDVYTVLSQCSPGPVHIIISRHPD 576

  Fly   422 QQQQQQSVQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQ 486
            .:..:|.:.:   ..||:.::         :|.:|                          :.:|
Zfish   577 PKVSEQQLNE---AISQAVEN---------SRLRK--------------------------DRSQ 603

  Fly   487 QATPAATTLYRSSSTSQLSSSSYVKC-DDPTEGLNLQREQREQRLPRIASLK----SSSCDDIAK 546
            .:.....:..|...:...|....::| |..|..|..:|.|:    |.|.|..    |..|
Zfish   604 WSMDGCNSSLRRPESCCHSRQKCMRCVDRSTSQLTCRRTQK----PMIRSCSEGAYSQRC----- 659

  Fly   547 VSSCLTASTSSGS--AAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENH 609
               |:..||::.|  ....:....:|..:.....:.|...|....  .||.        .|...:
Zfish   660 ---CIPNSTTAQSFLHTDHVSLTTNSETSLNNTLSQSSFTDDDYN--IPYK--------CPVNFN 711

  Fly   610 G------NVPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSP---EQAMLN--------- 656
            |      |....|   :.:.|:.::|.|....|:....|....|.||   |..||:
Zfish   712 GKQTFDVNASSGL---VNQPRKYYRQQQEVSSQEALNVSSGSSRDSPVKEEDLMLSQSNCQFFCS 773

  Fly   657 ------NVSR----NDSITSKDWEPLYQRLSSCLSSNESGYDSDGGATGARLGNNLSISG---GD 708
                  .:||    |:.:...:   |..:.|:|:|..:    ||....|.||..:...|.   |.
Zfish   774 LYRALRKISRLLFKNEVVEHAE---LGTKASACISEPK----SDSTHRGDRLHKDPECSSQVCGS 831

  Fly   709 TESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYE-----TE 768
            ::.:.   |:|.:.:.:|:.:.:...:.::     .|..|.|.||..:|  .:|.|.|     :|
Zfish   832 SKRVG---LRRQAHLEVSTDQPLDPWVKLT-----DSPENQSYCSKTMS--DHNGDSEVNGTASE 886

  Fly   769 TIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMA---QKDGRLRLGDE 830
            |...:..|....:|      |..::||:.....:.:..|    ..:|...|   |:|.|
Zfish   887 TTESKSEQATSVKK------GPPVAPKSARARQSMKSIR----SGKPITEALRNQQDNR------ 935

  Fly   831 IVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRL---S 892
                  .|..| ::|....|..||..:..|.        ..::.|.|....||......|:   :
Zfish   936 ------SHETG-RTFGISSRAASSGGNLSIR--------QKISSFETFSSPDGSERPSWRMAPTA 985

  Fly   893 YVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSS 957
            .|..|:.|...||.......:.|:...|      .:..|.|.:....|.:|:|
Zfish   986 SVPPTEKTTKTSSADYSNADRTRVNTSN------LRNNDYCQSTPPISATTLP------------ 1032

  Fly   958 TPRHSLDVGAPEHELLRRRARSSSGQRSLAL------------------TPTPLFASGSSSCSSS 1004
            :..||..:....|..:.:::.|...:...::                  |...|.:|..||
Zfish  1033 SEEHSTSLILESHPEVEKQSTSHDSETCKSIPVEEPTVDPTEEITTAVETEQELVSSAKSS---- 1093

  Fly  1005 PNHRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQF 1069
                 :|.|::|.:..::.....::..:||......:.:.|.:.::    ||....|.|..|::.
Zfish  1094 -----VDTEHEPVSSAETEQEPVSSTKSSVETEPVTSAETKQEPVS----SEKDLPSVTHVPRRS 1149

  Fly  1070 GQRTHYARNSINLANSHYRSLR--------------------------FAHSRLSSSRLSLFMQA 1108
            .............|.:|..|||                          .:.|...||.|...||:
Zfish  1150 SSSKEAPGEKAEEAGTHAVSLRTRSLPLSPSSDGPISSGLEGESLGIILSFSNQVSSALMRSMQS 1214

  Fly  1109 PPNS--LTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPK--SVSLFSPNPYV- 1168
            .|.|  :.:|...:..|.|      .|.|..::....:..|.|..::::.|  ||||.......
Zfish  1215 LPQSPCIRLGNPWSAPPGS------PLHNPIEEDSAAENPHASTALENNEKGFSVSLAELRERTI 1273

  Fly  1169 -------NASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKL----------TIRDEEMAEV 1216
                   .....|..|.|||.|..     |.:::...|...:.::          |:|..|...|
Zfish  1274 ERGEECKTDDWKPEQALTSASAAC-----AQSMLSVLPQPEIQRMIQEVKDLDEDTLRQLEDIHV 1333

  Fly  1217 IRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAG 1281
            :.....||:|                 |||||.||.|..  |....|..|||||.||.:||::.|
Zfish  1334 VILHKEEGAG-----------------LGFSIAGGIDLE--NKATTVHRVFPSGLAAQEGTIEKG 1379

  Fly  1282 DEIVEINGNSVQGMSHAETIGLFKNVREGTI---VLKILRRKLQKAKS 1326
            ||::.|||.:::.::|::...:.:..|  |:   |:.:.:.|..:.||
Zfish  1380 DEVLSINGQTLKNVTHSDATAILRQSR--TLKQAVVVVSKNKDAEGKS 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	12/55 (22%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	29/87 (33%)
il16	XP_021333386.2	None