DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and il16

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_021333386.1	Gene:	il16 / 100534674	ZFINID:	ZDB-GENE-130103-3	Length:	1540	Species:	Danio rerio

Alignment Length:	484	Identity:	127/484 - (26%)
Similarity:	186/484 - (38%)	Gaps:	115/484 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   887 QRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLM 951
            ||.|...::|.::  .|||.:...|.:..:...::..|         ||.|.......|..:||.
Zfish    33 QRRRTKRMERGKA--GLSSKKLAVLSRSLLICSSSAHE---------DASSPEEKYREPWDVPLE 86

  Fly   952 QHRRSSTPRH---SLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRL---- 1009
            ..|...|...   |:......||..:|..|     ||.::..|..:    ..|.::.:..|
Zfish    87 DRRPDGTLMSRSVSVQTSYRGHEGPKRAMR-----RSFSIKETSFW----RMCVATRDDALHTAD 142

  Fly  1010 -----LDNENDPANDTDSYTPVY-ANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQ 1068
                 .|||...|.|....|.:| ..|.|..                     .|..::..|||:.
Zfish   143 RKLQNCDNEASVAQDLHRETYIYFGERLAPF---------------------NGQVINEQPNPEP 186

  Fly  1069 --FGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEG----VANTPSSTA 1127
              ...:|..:||:.:.|.:..|:| |.::..|            ..|..|.|    :.|..:...
Zfish   187 DLHKHKTTESRNTSSKAFTENRAL-FTNTTES------------QQLGYGYGEKEPMGNNNNLQM 238

  Fly  1128 TTTTDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPY----------VNASSSPASASTSA- 1181
            .......:..:...|:.|..|.:..|.|..:.:  |.:||          ......|.||..:|
Zfish   239 PIIKVSDDDVKDIDNEDQGCQEMSCKRSRSNST--SVHPYWIGDLETIIMKTPELFPCSAHNTAA 301

  Fly  1182 --GAGSSLAPPAAALMHHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTP----------KTIT 1234
              |...||:..    :....|:|.|           |:|.|.|..|....|          ..|.
Zfish   302 FYGNRKSLSQQ----LEFPHSVPQA-----------VVRPSRSLSSAHLVPSCSSVQAFIISNIV 351

  Fly  1235 FFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAE 1299
            ..||.| |.|||||||||||..|.|||:|||:||.|.||.||.||.||||:|:||.|:.|::|.:
Zfish   352 LMKGHG-KGLGFSIVGGRDSMYGPMGIYVKTIFPGGAAAADGRLQEGDEILELNGESLHGLTHED 415

  Fly  1300 TIGLFKNVREGTIVLKILRRKLQKAKSMG 1328
            .:..||.|::|.:.| ::|..|:....||
Zfish   416 ALHKFKQVKKGLLTL-VVRTSLRVGAVMG 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	48/96 (50%)
il16	XP_021333386.1	PDZ_signaling	350..433	CDD:238492	47/84 (56%)
		PDZ_signaling	489..571	CDD:238492
		MGC-24	620..>696	CDD:310122
		GREB1	<795..>990	CDD:318077
		Atrophin-1	1006..>1234	CDD:331285
		PDZ_signaling	1331..1406	CDD:238492
		PDZ	1448..1535	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24215
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000