Protein Alignment a and XB5786944

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_004916893.1
• Gene: XB5786944 / 100494793
• XenbaseID: XB-GENE-5786945
• Length: 682
• Species: Xenopus tropicalis
• Alignment Length: 913
• Identity: 172/913 - (18%)
• Similarity: 281/913 - (30%)
• Gaps: 354/913 - (38%)

  Fly   456 KALKNFFHRIGSTGMLN--------HRS----HNLL-KASEAAQQATPAATTLYRSSSTSQLSS- 506
            :.||||........|..        |||    .||| |.|.:....|.....:.|....:.|.:
 Frog    66 RCLKNFLQEKDFCPMDRKKLCFQDCHRSSLLVRNLLDKLSVSCPFLTDCKQVMQRCELDAHLKNR 130

  Fly   507 -SSYVKCDDPTEGLNL-----QREQREQR-LPRIASLKSSSCDDIAKVSSCLTASTSSGSAAGSL 564
             ..:.||....|..|.     :..|..|| ||:.:.:.|...:      |.|.|..|.|::...|
 Frog   131 CQGFRKCRPVKEKTNATICLRKNAQDGQRDLPQTSGISSVIAE------SSLAAVVSLGTSEPGL 189

  Fly   565 GSPPSSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQ 629
            .:|...            :||....|..|     .|.|:|.|.:...:
 Frog   190 VNPAFD------------EHDDDDDGDLP-----QRTSLLAETSTVEI----------------- 220

  Fly   630 HQRDLLQQEQTSSPLPQR-RSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSDGGA 693
            |:.|      ..:||..| ...:...|.|:...:.:|                  :|...:||..
 Frog   221 HRVD------PENPLGMRIVGGKDTPLGNIVVQEILT------------------DSLVATDGKV 261

  Fly   694 T-GARL----GNNLSISGGDTESIASGTLKRN-SLISLSSSEGVGMGMGMSLGLGAPSTRNSSIC 752
            | |..:    |.|:|   ..|.|.|...|::. |::.|:        :....|....|:|..:
 Frog   262 TPGDHILEVNGTNIS---NVTHSQAIALLRQPCSVLQLT--------LVQEKGFSPQSSRTEN-- 313

  Fly   753 SAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYG 817
                |.||  ..:.|:.|     ||.|.::.:.:.:||.|..||       ::....:::|...|
 Frog   314 ----STGG--SPHSTKVI-----QVTLTKRDRSEPLGIKLVRKT-------EEPGIFVLDLLDGG 360

  Fly   818 MAQKDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRID 882
            :|.|||||:..|:::::||.:|:                         |....|....
 Frog   361 LAYKDGRLKCNDKVLSINGHNLK-------------------------HGTPETAAQI------- 393

  Fly   883 GMSTQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTP 947
             :.:...|:::|                     :..|..:|..:...|......|.......|..
 Frog   394 -IQSSEARVNFV---------------------VLRHMIDQPVDINEESSSSGSSNGGSPVHPRK 436

  Fly   948 MP-LMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLD 1011
            .| |..:||.||....::.|.|:||
 Frog   437 RPSLRPNRRKSTHHKDVNPGPPDHE---------------------------------------- 461

  Fly  1012 NENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYA 1076
                                                                             
 Frog   462 ----------------------------------------------------------------- 461

  Fly  1077 RNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQ 1141
             .|:|:....|.||                     .:|:|.|            .||.|:
 Frog   462 -KSVNVKKEQYESL---------------------GITIGGG------------RDLKNK----- 487

  Fly  1142 NQQQTHQSLYIKHSPKSVSLF------SPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPS 1200
                  ..:|:........||      ..:..::.:.:..::.:.:.|.|:|...||:   |...
 Frog   488 ------LPIYVSSIQPVGCLFRDGRIRKGDVLLSINGTDLTSLSYSDAISALKTNAAS---HTVV 543

  Fly  1201 LPVAKLTI--RDEEMAEVIRASMSEGSGRCTPKTITFFKGP--------------GLKSLGFSIV 1249
            |...::|:  |.:|..|.......|..|..:|..:.:...|              ..:|.|||||
 Frog   544 LKALEVTVGERLDEPVEHAAGVTREPGGIWSPLWVYWLALPSSLHWCRHITLRKTSSESWGFSIV 608

  Fly  1250 GGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVL 1314
            ||.:..||:...|:||:.|...|..|..|:.||||||:||.|..|||:|:.|.:.|. ::..:.|
 Frog   609 GGFEEGKGDQPFFIKTIVPGTPAFYDKRLKCGDEIVEVNGVSAVGMSNAQLIPMLKE-QKNRVTL 672

  Fly  1315 KIL 1317
            .::
 Frog   673 TVV 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	12/52 (23%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	34/98 (35%)
XB5786944	XP_004916893.1	mRING-HC-C3HC3D_LNX2	39..83	CDD:319694	5/16 (31%)
		PDZ1_LNX1_2-like	213..301	CDD:467165	23/139 (17%)
		PDZ2_LNX1_2-like	325..407	CDD:467166	25/147 (17%)
		PDZ3_LNX1_2-like	462..548	CDD:467167	21/132 (16%)
		PDZ4_LNX1_2-like	593..679	CDD:467168	33/84 (39%)