Protein Alignment a and il16

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_017947938.2
• Gene: il16 / 100493920
• XenbaseID: XB-GENE-489722
• Length: 1305
• Species: Xenopus tropicalis
• Alignment Length: 1454
• Identity: 263/1454 - (18%)
• Similarity: 422/1454 - (29%)
• Gaps: 614/1454 - (42%)

  Fly   222 YVAQRLHAASSSCL--------YEKGSNASGGASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDE 278
            |:|.:|:.::.:..        ||:||..:       |||.:
 Frog     2 YLAMQLYYSAENIKSDMPNKYDYERGSIFT-------SSLKM----------------------- 36

  Fly   279 HKSNSLPATEASRNSNSSSNMNGSSNSNSLDVSNS-NSHSGSS-----TSLASTTRNVFTWGKRM 337
            |:.|       |....:....|..|.|.||.:.|: ||..|||     |.:..|..:
 Frog    37 HRQN-------STGKKNKKIKNFRSLSKSLILCNAKNSDDGSSLEEKYTEITDTPHS-------- 86

  Fly   338 SRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTHHK--SGSGGSSGPSSAKASASPTG-------GH 393
                 |::.|||..|   ..|.:.|:...|...|  .....|:.|:.:|.|.....       |.
 Frog    87 -----LVRDSDSLTA---DTSQIGSMIPDPMIRKIIVSKAASADPTPSKPSLVEANYFLEYQTGL 143

  Fly   394 QNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQQSVQDVGTGQ-SQSAQSTPTHQFQAAARPQKA 457
            :|          .|   |:: :|.|..:.:....||.....|. .......|||     .|.:.:
 Frog   144 EN----------PC---PLK-MKARCTRTRSNSTSVNPYWIGDIDPPLTKRPTH-----CRERHS 189

  Fly   458 LKNFFHRIGSTGMLNHRSHNLLKASEAAQQATPAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQ 522
            ...:.:|...:..|:..|..:...|..:           ||.||:||.|:
 Frog   190 ANLYSNRKSMSQQLDCLSGGVQSVSRPS-----------RSLSTAQLIST--------------- 228

  Fly   523 REQREQRLPRIASLKSSSCDDIAKVSSCLTASTSSG--SAAGSLG------SPPSSAAAGG---- 575
            |..:...:..|..:|..        ...|..|...|  |..|.:|      .|..:|||.|
 Frog   229 RSPQASMISNIILMKGQ--------GKGLGFSIVGGKDSIYGPVGIYVKTIFPEGAAAADGRLQE 285

  Fly   576 -------------GGTANSG--QHDPSRRGAFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQRE 625
                         |.|.|..  :....::|..... :|:.|..|.|:     ||:...|:.|.:.
 Frog   286 GDEILELNGESMYGLTHNDALQKFKQVKKGVLTLT-VRTGLGTLEEK-----PGYFASQMFRSKS 344

  Fly   626 QHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGYDSD 690
            ......|:         |.|.:......:||:.:.||.:..:
 Frog   345 SSCCVARE---------PSPLQSESHTFLLNSHNPNDRVLME----------------------- 377

  Fly   691 GGATGARLGNNLSISGGDTESIASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAP 755
                                            :::....|||:|:|              :||.|
 Frog   378 --------------------------------VTMHKESGVGLGIG--------------LCSVP 396

  Fly   756 VSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQ 820
             :.||.                                            :...|..|.|..:|.
 Frog   397 -NCGGI--------------------------------------------FSIFIHLLSPGSVAH 416

  Fly   821 KDGRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRI-DGM 884
            .|||||.|||||.:| :.:.|.:|..||..|||......:.::|:......:::...|..: ..:
 Frog   417 MDGRLRAGDEIVEIN-ESVVGNKSLNEVYALLSHCPPGPVTILISRHPDPQISEQQLKNAVSQAV 480

  Fly   885 STQR-----HRLSY-----------------------------VQRTQSTDSLSSMQ------SL 909
            ...|     |..||                             .:|.|.....||.:      ||
 Frog   481 ENSRCEKDPHPWSYEGERKLFFCCHGKYQCESCIGRHASYLYNSRREQKQMVRSSSEGNYGPTSL 545

  Fly   910 QLQQE--------------------------RIQGHNTEQEQEAQGEDQCDARS--------MAS 940
            ..|..                          |::.|:....:...|......:|        :..
 Frog   546 GSQSHVVASRVHSANVPLGTEPALLHYSTPVRVENHSPFNPEGLSGSQASFKKSNGHSGEILVKK 610

  Fly   941 VSTMPTPMPLMQHRR---------------------------------------SST-------- 958
            ::|.|.|.|...::.                                       |||
 Frog   611 LTTKPIPPPRKYYKEDSREDVNHNQENGQSVDETGNLQLKGNQQITGESILDTSSSTSECSYTSA 675

  Fly   959 ---PRHSLDVGAP---EHELLRRRARSSSGQRSLALTP------------TPLFASGSSSCSSSP 1005
               .:|| |.|.|   ...||||:||......:.:..|            :||...|
 Frog   676 AEPDKHS-DTGNPVSNHRPLLRRQARVDYSFDTTSEDPWVRISDCIKNLFSPLINEG-------- 731

  Fly  1006 NHRLLDNE---------------NDPANDTDSYTPV----------------------YAN---- 1029
             |.|:|.|               :.|..|:...:|.                      |.|
 Frog   732 -HNLMDLESSISAAGGNTERLRRDSPCEDSQMCSPQDTFKKGPPVAPKPAWYRQSLKGYKNVDKK 795

  Fly  1030 --RAASVCVASSLADDEKWQLLAR---------------------KRCSEGSALSATPNPQQFGQ 1071
              .:.|:.....:.::.|.|..:|                     |....|:..|:.||.:.|.:
 Frog   796 PTESTSLAKYKEIQNNIKPQTSSRTSSIKQKINSFETFSTPSPAGKISDRGNVTSSAPNDKPFNK 860

  Fly  1072 --------------------------RTHYA------RNSINLANSHYRSLRFAHSRLSSSR--- 1101
                                      :.|.|      :....|:.|..:| .|...|.|||.
 Frog   861 QEVESVTVCLNNVTMSTAEIQVPEVIQPHVAIPKSPEKEEPELSQSPQKS-SFQGMRRSSSTSNE 924

  Fly  1102 ---LSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQ-----NQQQTHQSLYIKHSPKS 1158
               ||.....|....|..:...:.|.|.:|.:..|...:...:     ||..:.....:...|:|
 Frog   925 PQFLSSEFNEPIPYKTPSQRSRSFPLSASTPSDALKINENCSKIYSISNQVSSALMKSLLCFPQS 989

  Fly  1159 VSLFSPNPYVNAS-------SSPASASTSAGAGSSL--------------------APPAAALMH 1196
            ..|...:|:.|.|       |||.:.|.:..:|.|:                    .|..:..:.
 Frog   990 PQLQVTDPWPNESHPEDEVPSSPKTESHNLDSGFSVNLSELREYGAGQPEKEKEEDVPEQSLSLP 1054

  Fly  1197 HRPS-------LPVAKLTIRDEEMAE-------------VIRASMSEGSGRCTPKTITFFKGPGL 1241
            ..|:       ||..:||...||:.|             |:.....||:|
 Frog  1055 SVPTGQSVISLLPREELTQLIEEVKELDEETLKQFDDIHVVVLHKEEGTG--------------- 1104

  Fly  1242 KSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKN 1306
              ||||:.||.|..  |..|.|..|||:|..|.:||:|.||:::.|||.|::|::|.:.:.:.:.
 Frog  1105 --LGFSLAGGLDLE--NKAITVHRVFPTGLTAQEGTIQKGDKVLSINGKSLKGVTHNDALAILRQ 1165

  Fly  1307 V---REGTIVLKILRRKLQKAKSM 1327
            .   |:..||:|..:...|.::|:
 Frog  1166 ARHPRQAVIVIKKEKDGEQTSESL 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	21/52 (40%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	29/87 (33%)
il16	XP_017947938.2	PDZ3_PDZD2-PDZ1_hPro-IL-16-like	237..322	CDD:467240	17/93 (18%)
		PDZ4_PDZD2-PDZ2_hPro-IL-16-like	372..461	CDD:467241	34/203 (17%)
		PDZ6_PDZD2-PDZ3_hPro-IL-16-like	1092..1177	CDD:467243	33/103 (32%)
		PDZ7_PDZD2-PDZ4_hPro-IL-16-like	1211..1295	CDD:467244