DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and whrna

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	939	Identity:	195/939 - (20%)
Similarity:	313/939 - (33%)	Gaps:	313/939 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 LKQQIQRQREQH-------QQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDW--EP 671
            |...::|::..|       :::..||:|..:....:|.:|.....:...:.|:|.:....:  |.
Zfish    39 LLSDLEREQFIHCLNVYHSKRNVYDLVQTLKVILNVPSKRQLLPMLRLVIPRSDQLLFDQYTSEG 103

  Fly   672 LYQRLSSCLSSNESGYDSDGGATGARL----GNNLSIS----GGDTESIASGTLKRNSLISL--- 725
            ||  |.|.:.:...  |.||...||..    |.|...|    .|..:||::.:....:||.|
Zfish   104 LY--LKSEIHARNG--DPDGAQEGANSSPTHGANFPASQVALRGSPDSISTSSDGTATLIPLLGR 164

  Fly   726 ------------------SSSEGVGM--------GMGMSLGLGAPST------------------ 746
                              .|:||:|.        |:|:.:.|..|.:
Zfish   165 NFLPEPPGEIRQVILKRHKSNEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRMGDQIMKVND 229

  Fly   747 ----------------RNSSICSAPVSL----GGY--NY--------------------DYETET 769
                            .:..:|.:..|:    |||  |:                    ::.:.|
Zfish   230 KVFDRVTHADAVKVLKGSKKLCMSVRSVGRIPGGYITNHVYTWVDPQGRSVSPPPDLLAEHRSAT 294

  Fly   770 IRRRFRQ----VKLERKCQEDYIGIVL----SPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLR 826
            :||...|    ::|.:...|..:.:||    |...::....|......|..:: .|.|.:.|.::
Zfish   295 LRRSNSQGRSHMQLLQDGDEKKVNLVLDDGRSLGLMIRGGAEYSLGIYITGVD-RGSAAECGGIK 358

  Fly   827 LGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDF---------------- 875
            :||:|:.|||:....|.....|:.|.||           |..:.||.|.
Zfish   359 VGDQILEVNGRSFLSIPHDEAVRVLKSS-----------HHLMMTVKDVGRLPHTRTVVGETKWI 412

  Fly   876 -------------YTKIRID-GMSTQRHRLSYVQRTQSTDSLSSM--QSLQLQQERIQGHNTEQE 924
                         .|.|.:| |.||......|.....|..:|||:  ||..:.:|:.:...||.|
Zfish   413 ASSQISDSSASSSVTGISLDQGASTSAKGGFYKGVAGSQVTLSSLVNQSRAMLEEQARHLLTEPE 477

  Fly   925 QEAQG---EDQCDARSMASVSTMPTPMPLMQ----HRRSS---------TPRHSLDVGAPEHELL 973
            ::..|   ::..|..    |......|.|.:    |.:.|         ||:   ||...:..:|
Zfish   478 RQTMGYYIQEYRDGH----VGVEQLVMALFELFNTHAKFSLLSEVRGIVTPQ---DVEKFDGLVL 535

  Fly   974 RR-----RARSSSG---QRSLALTPTPLFASGSSSCSSSPNHRLLDNENDPANDTDSYTPVYANR 1030
            ||     :||...|   |.|.::...| ....|||.|...|..|....||...:.:       ..
Zfish   536 RREIDALKARQGGGAGFQDSFSMVSYP-DTLASSSASFMTNTTLSSARNDGVAENN-------GE 592

  Fly  1031 AASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNSINLANSHYRSLRFAHS 1095
            ..|:..:::|.|..    |.....:..|..|..|.|....||....:.:::...|.
Zfish   593 QGSLEHSNALPDIS----LDEVHSTSDSPPSFKPPPPPGLQRRPSRKATLSKRPSS--------- 644

  Fly  1096 RLSSSRLSLFMQAPPNSLTVGEGVANTP----SSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSP 1156
              |||:..|:..||..|.|........|    |...|...|:...|....:|..      |...|
Zfish   645 --SSSQSGLYFTAPSRSHTRESKHPKAPKAFMSPPGTLKIDVPASQLSVVSQHP------IGPFP 701

  Fly  1157 KSVSLFSPNPYVNASSS----PASASTSAGAGSSLAPP----------------AAALMH----- 1196
            :   :.|||....|.||    |.:.:..|..|....||                .|:..|
Zfish   702 R---VQSPNKAKPAQSSSPIPPPAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHFVMVE 763

  Fly  1197 -HRPS----------LP------VAKLTIRDEEMAEVIRASMSEGSGRCTPKTI----------- 1233
             |||:          ||      :::|:...:.::|.....:.| |||.:..|.
Zfish   764 VHRPNAEPDVNEVRPLPQVRGGTLSQLSDSGQTLSEDSGVDIPE-SGRLSKDTSPRPARTRAPRD 827

  Fly  1234 ------TFFKGPGL--------------KSLGFSIVGGRDS----PKGNMGIFVKTVFPSGQAAD 1274
                  |..|.|||              .:||.:|.||.::    |:      :.|:...|.|.:
Zfish   828 GHGGGETSAKPPGLLEPMSTLVRVAKSASTLGIAIEGGANTRQPLPR------IVTIQRGGSAHN 886

  Fly  1275 DGTLQAGDEIVEINGNSVQGMSHAETIGL 1303
            .|.|:.|..|:|:||.|::|..|.|...|
Zfish   887 CGQLKVGQVILEVNGVSLRGKEHREAARL 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	22/97 (23%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	27/109 (25%)
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822	10/62 (16%)
		PDZ_signaling	174..255	CDD:238492	9/80 (11%)
		PDZ_signaling	314..394	CDD:238492	22/91 (24%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	19/85 (22%)
		PDZ_signaling	848..919	CDD:238492	21/74 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900