DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SRY

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_003131.1	Gene:	SRY / 6736	HGNCID:	11311	Length:	204	Species:	Homo sapiens

Alignment Length:	180	Identity:	54/180 - (30%)
Similarity:	81/180 - (45%)	Gaps:	54/180 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 GHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRL 479
            |:|..:  :|||||||:||::|:|||:....|.|.||.|||.||.:||.::.|:|.|:::|..:|
Human    54 GNVQDR--VKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKL 116

  Fly   480 SKLHMEQHPDYRYRPR------PKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGSG 538
            ..:|.|::|:|:||||      ||...::......:...:|.:.||
Human   117 QAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNR------------------- 162

  Fly   539 SLCADACPKGSGGSNSQVAVAAAAAVYHLQDMASSAASTAHGHDCGHTPP 588
             |..|.|.|                          |..:...|..||.||
Human   163 -LYRDDCTK--------------------------ATHSRMEHQLGHLPP 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	33/70 (47%)
SRY	NP_003131.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000269\|PubMed:15297880	59..136		37/78 (47%)
		SOX-TCF_HMG-box	59..130	CDD:238684	33/72 (46%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:12764225, ECO:0000269\|PubMed:15746192	61..77		11/15 (73%)
		Sufficient for interaction with EP300. /evidence=ECO:0000269\|PubMed:15297880	107..139		11/31 (35%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:15297880	130..136		3/5 (60%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269\|PubMed:15469996	138..155		2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..204		5/11 (45%)
		Necessary for interaction with SLC9A3R2. /evidence=ECO:0000269\|PubMed:9054412	198..204
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840