DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SOX10

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_008872.1	Gene:	SOX10 / 6663	HGNCID:	11190	Length:	466	Species:	Homo sapiens

Alignment Length:	300	Identity:	80/300 - (26%)
Similarity:	108/300 - (36%)	Gaps:	119/300 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 DPESLNSGQLGPVPA------SPSSQP------------LRQGNGHGHGGN-------------- 413
            :.:.|:..:|.||.:      ||.|.|            ||...|.|..|.
Human     3 EEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQDGEADDDK 67

  Fly   414 ---------------------------HGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNS 451
                                       :|...||||:|||||||||||:..|||:....|.:||:
Human    68 FPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNA 132

  Fly   452 NISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMRISEYKVLM 516
            .:||.||..|:.::.:||:|:.||..||...|.:.||||:|:||
Human   133 ELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPR--------------------- 176

  Fly   517 RNRRAEMRQLWCRTGGVSGGSGSLCADACPKGSGGSNSQVAVAAAAAVY---HL------QDMAS 572
              ||        :.|..:.|...     ||   ||...|...||..|.|   ||      :....
Human   177 --RR--------KNGKAAQGEAE-----CP---GGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPM 223

  Fly   573 SAASTAHGHDCGHTPPQQFFYPPESLSPSGFSSDEVELAS 612
            |..:..|.....|.||.    ||        ::.:.||.|
Human   224 SDGNPEHPSGQSHGPPT----PP--------TTPKTELQS 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	35/70 (50%)
SOX10	NP_008872.1	Sox_N	12..93	CDD:315171	12/80 (15%)
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	62..102		2/39 (5%)
		SOX-TCF_HMG-box	103..173	CDD:238684	35/69 (51%)
		Nuclear export signal	134..145		5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..199		18/77 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..274		10/51 (20%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	228..310		8/35 (23%)
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	353..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		13/63 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740