DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SOX9

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens

Alignment Length:	348	Identity:	79/348 - (22%)
Similarity:	120/348 - (34%)	Gaps:	136/348 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 TADCSKNFSPSPTDNLSIASV------SEAQDSEMDAPLNLSKPKGSPSSSPNSSSQRDHCENLT 315
            |.:..|..|.:|:..:|..|.      ....|:|...|...:.|||.|.....|.      |:..
Human    11 TDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESE------EDKF 69

  Fly   316 PVVSSPPLSWHQGQPHYAEIELPLLKSHGRVWNSAVACSGGSRATRVSRDSVNSCGTNSERSAAL 380
            ||.....:|             .:||  |..|.
Human    70 PVCIREAVS-------------QVLK--GYDWT-------------------------------- 87

  Fly   381 DPESLNSGQLGPVPASPSSQPLRQGNGHGHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKAC 445
                     |.|:|...                :|...:|||:|||||||||||:..|||:....
Human    88 ---------LVPMPVRV----------------NGSSKNKPHVKRPMNAFMVWAQAARRKLADQY 127

  Fly   446 PDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMRIS 510
            |.:||:.:||.||..|:.::.::|:|:.||..||...|.:.||||:|:||.:::
Human   128 PHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKS----------- 181

  Fly   511 EYKVLMRNRRAEMRQLWCRTGGVSGGSGSLCADACPKGSGGSNSQVAVAAAAAVYHLQ-DMASSA 574
                 ::|.:||..:                          :..|..::..|....|| |...|:
Human   182 -----VKNGQAEAEE--------------------------ATEQTHISPNAIFKALQADSPHSS 215

  Fly   575 ASTAHGHDCGH---------TPP 588
            :..:..|..|.         |||
Human   216 SGMSEVHSPGEHSGQSQGPPTPP 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	34/70 (49%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		14/61 (23%)
		Sox_N	22..94	CDD:403592	22/133 (17%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		13/117 (11%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		13/117 (11%)
		SOX-TCF_HMG-box	104..174	CDD:238684	34/69 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		24/121 (20%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		4/15 (27%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740