DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SOX4

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_003098.1	Gene:	SOX4 / 6659	HGNCID:	11200	Length:	474	Species:	Homo sapiens

Alignment Length:	294	Identity:	94/294 - (31%)
Similarity:	122/294 - (41%)	Gaps:	71/294 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 NSERS-AALDPESLNSG---QLG----PVPASPSSQPLRQGNGHGHGGNHGHVHSKP-------- 421
            |:|.: |.|..||.:||   :||    |.|.|.:|.          ||.    ...|
Human     7 NAENTEALLAGESSDSGAGLELGIASSPTPGSTAST----------GGK----ADDPSWCKTPSG 57

  Fly   422 HIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQ 486
            ||||||||||||::.|||||::..|||||:.|||.||.|||.:.::||.|:..|..||...||..
Human    58 HIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMAD 122

  Fly   487 HPDYRYRPRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGSGSLCADACPKG--- 548
            :|||:||||.|   :..|.....|......:......:......||..||.|...::|...|
Human   123 YPDYKYRPRKK---VKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGA 184

  Fly   549 -SGGSNSQVA----------------------------------VAAAAAVYHLQDMASSAASTA 578
             .||:||:.|                                  .|||||.....:.|.:||...
Human   185 SGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAAALLP 249

  Fly   579 HGHDCGHTPPQQFFYPPESLSPSGFSSDEVELAS 612
            .|....|....:...|..|.|.|..:|....||:
Human   250 LGAAADHHSLYKARTPSASASASSAASASAALAA 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	41/70 (59%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		17/64 (27%)
		SOX-TCF_HMG-box	58..129	CDD:238684	41/70 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..228		19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..286		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740