DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and SOX17

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_071899.1	Gene:	SOX17 / 64321	HGNCID:	18122	Length:	414	Species:	Homo sapiens

Alignment Length:	267	Identity:	79/267 - (29%)
Similarity:	117/267 - (43%)	Gaps:	47/267 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 SRDSVNSCGTNSERSAALDPESLNSGQLGPVPASPSSQPL--------RQGNGHGHGGNHGHVHS 419
            |.|:..:....|:..:||  .::.:| |||.|.:.|..|:        ...|.....|..|....
Human     3 SPDAGYASDDQSQTQSAL--PAVMAG-LGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKG 64

  Fly   420 KPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHM 484
            :..|:||||||||||||||:::.:..||:||:.:||:||..|||::.|:|:|:.||..||...||
Human    65 ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHM 129

  Fly   485 EQHPDYRYRPRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGSGSLCADACPKGS 549
            :.||:|:||||                       ||.::::|....||...|    .|:......
Human   130 QDHPNYKYRPR-----------------------RRKQVKRLKRVEGGFLHG----LAEPQAAAL 167

  Fly   550 GGSNSQVAVAAAAAVYHLQDMASSAA-----STAHGHDC---GHTPPQQFFYPPESLSP-SGFSS 605
            |....:||:......:..|...:...     ...|..||   |..|...:..|....|| .|...
Human   168 GPEGGRVAMDGLGLQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPLPTPDTSPLDGVDP 232

  Fly   606 DEVELAS 612
            |....|:
Human   233 DPAFFAA 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	38/70 (54%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..66		4/29 (14%)
		SOX-TCF_HMG-box	67..138	CDD:238684	38/70 (54%)
		Sox_C_TAD	201..412	CDD:288887	11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..286
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810