Protein Alignment Sox102F and SOX6

DIOPT Version :10

• Sequence 1: NP_001014695.1
• Gene: Sox102F / 43844
• FlyBaseID: FBgn0039938
• Length: 618
• Species: Drosophila melanogaster
• Sequence 2: NP_001139291.2
• Gene: SOX6 / 55553
• HGNCID: 16421
• Length: 828
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 212/725 - (29%)
• Similarity: 292/725 - (40%)
• Gaps: 232/725 - (32%)

  Fly    11 EKEHSDLGMIKQLQLIRNRILSQAHYDSMTDIDAS-AQQQQQLQNVQRLQHESCLQELHNHLSSQ 74
            |||.....||.||..:|.::|  |.:|....:.|| .::|:|..::.|.|.|...::....|..|
Human   186 EKERQLSTMITQLISLREQLL--AAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQ 248

  Fly    75 YGAVRFTAANPQHQNQQAVSVSSGNLMPFLPAFLQPPMPNAQQLLQLIPGHENAQSVPTHHHSHP 139
            :..                     ||:              ||.:| :.||.....:|...|...
Human   249 HKI---------------------NLL--------------QQQIQ-VQGHMPPLMIPIFPHDQR 277

  Fly   140 QSEAFSTHKMALAPMWSTAAVAAAH---------------------IQAALAAAAVAAAN----N 179
                            :.||.|||.                     |.:.:||||.:..:    .
Human   278 ----------------TLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQ 326

  Fly   180 NKNSSHFSNNTNIVGLATRGNELLNTDSDPQMEIGETRRGGN-----------GGSCRSRPESPT 233
            ..:.||...|..:.||:.|....|:|     .|.|    ||:           .....|...||.
Human   327 KGHVSHPQINQRLKGLSDRFGRNLDT-----FEHG----GGHSYNHKQIEQLYAAQLASMQVSPG 382

  Fly   234 YENPPYEILSYSHNTPPESPHGRTADCSKNFSPSPT----DNLSIASVSEAQDSEMDAPLNL-SK 293
            .:.|          :.|:.|:  ||.     :.|||    :....:.|::.:|.....|||| |:
Human   383 AKMP----------STPQPPN--TAG-----TVSPTGIKNEKRGTSPVTQVKDEAAAQPLNLSSR 430

  Fly   294 PK-GSPSSSPNSSSQRDHCENLTPVVSSPPLSWHQGQPHYAEIELPLLKSHGRVWNSAVACSGGS 357
            || ..|..||.|.:|     ||.|...:.|::    .|:.:.|..|:..|.||..:..:..|..|
Human   431 PKTAEPVKSPTSPTQ-----NLFPASKTSPVN----LPNKSSIPSPIGGSLGRGSSLDILSSLNS 486

  Fly   358 RATRVSRDSV--------------------------------------NSCGTNSERS------A 378
            .|....:|:|                                      |||....||:      .
Human   487 PALFGDQDTVMKAIQEARKMREQIQREQQQQQPHGVDGKLSSINNMGLNSCRNEKERTRFENLGP 551

  Fly   379 ALDPESLNSGQLGP--------------VPASPSSQPLRQGNGHGHGG-----------NHGHVH 418
            .|..:|...|:|||              ...:.|:..|:|......||           ..|...
Human   552 QLTGKSNEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRAS 616

  Fly   419 SKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLH 483
            |:||||||||||||||||||||||:|.|||||||||||||:|||:|||.:||||||||:||||:|
Human   617 SEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIH 681

  Fly   484 MEQHPDYRYRPRPKRTCIVDGKKMRISEYKVLMRNRRAEMRQLWCRTGGVSGGSGSLCADACPKG 548
            :|::|:|:|:|||||||||||||:||.|||.|||:||.||||.:
Human   682 LEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFF--------------------- 725

  Fly   549 SGGSNSQVAVAAAAAVYH--LQDMASSAASTAHGHDCGHTPPQQFFYPPESL----SPSGFSSDE 607
            :.|...|:.:.....|.:  ...||::..|.....||..|...    |..||    |..|..:|.
Human   726 TVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSAS----PEPSLPVIQSTYGMKTDG 786

  Fly   608 VELASQRELD 617
            ..||....::
Human   787 GSLAGNEMIN 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	HMG-box_EGL13-like	421..498	CDD:438848	62/76 (82%)
SOX6	NP_001139291.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..470		31/115 (27%)
		HMG-box_EGL13-like	619..696	CDD:438848	62/76 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..828		12/48 (25%)