DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox102F and SOX18

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_060889.1	Gene:	SOX18 / 54345	HGNCID:	11194	Length:	384	Species:	Homo sapiens

Alignment Length:	161	Identity:	62/161 - (38%)
Similarity:	87/161 - (54%)	Gaps:	20/161 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 CGTNSERSAALDPESLNSGQLG----PVPASP---------SSQPLRQG-NGHGHGGNHGHVHSK 420
            |.......||.|...|.:|...    ..||||         |.:|.|.| :..|.|.......|:
Human    20 CAWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAADESR 84

  Fly   421 PHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHME 485
              |:||||||||||||||:::.:..||:||:.:||:||..||.::.|:|:|:.||..||...|:.
Human    85 --IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLR 147

  Fly   486 QHPDYRYRPRPKRTCIVDGKKMRISEYKVLM 516
            .||:|:||||.|:    ..:|.|..|..:|:
Human   148 DHPNYKYRPRRKK----QARKARRLEPGLLL 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	36/70 (51%)
SOX18	NP_060889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		18/69 (26%)
		SOX-TCF_HMG-box	84..155	CDD:238684	36/72 (50%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	87..100		12/12 (100%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	111..123		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..218		12/33 (36%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	166..231		3/9 (33%)
		Sox_C_TAD	193..382	CDD:288887
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740