DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox102F and Sox13

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	XP_006249824.1	Gene:	Sox13 / 289026	RGDID:	1309674	Length:	613	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	169/607 - (27%)
Similarity:	249/607 - (41%)	Gaps:	191/607 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDQTNEKEHSDLGMIKQLQLIRNRILSQAHYDSMTDIDASAQQQQQLQNVQRLQHESCLQELHNH 70
            ::...|||...|.||.||..:|:::|: ||.:.........::|||...:.|.|.|...::....
  Rat   135 QESLAEKELQLLVMIHQLSALRDQLLT-AHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQL 198

  Fly    71 LSSQYGAVRFTAANPQHQNQQAVSVSSGNLMPF--LPAFLQPPMPNAQQLLQLIPGHENA---QS 130
            :..|:      ..|...|..|.|:      ||:  :|||     |::.|.|.:.|..:.|   |.
  Rat   199 IQQQH------KINLLQQQIQQVN------MPYVMIPAF-----PSSHQPLPVTPDSQLALPIQP 246

  Fly   131 VPTHHHSHPQSEAFSTHKMALAPMWSTAAVAAAH-IQAALAAAAVAAANNNKNSSHFSNNTNIVG 194
            :|.....:|.....|..    ||:.....||..| :|.......:.|
  Rat   247 IPCKPVEYPLQLLHSPP----APVVKRPGVATHHPLQEPPQPLNLTA------------------ 289

  Fly   195 LATRGNELLNTDSDPQMEIGETRRGGNGGSCRSRPESPTYENPPYEILSYSHNTPPESPHGRTAD 259
             ..:.:||.||.|.|.:::         .||..||.              ||..|
  Rat   290 -KPKVSELPNTSSSPSLKM---------NSCGPRPS--------------SHGAP---------- 320

  Fly   260 CSKNFSPSPTDNLSIASVSEAQ---DSEMDAPLNLSKPKGSPSSSPNSSSQRDHCENLTPVVSSP 321
             :::...|| .||.:..:.|..   .:..||...|....|:..:||::..::|    |..:.|||
  Rat   321 -TRDLQSSP-PNLPLGFLGEGDAVTKAIQDARQLLHSHSGALENSPSAPFRKD----LISLDSSP 379

  Fly   322 PLSWHQGQPHYAEIELPLLKSHGRVWNSAVACSGGSRATRVSRDSVNSCGTNSERSAALDPESLN 386
                                :..|:..:.|         ....:::..|..:..|..:   ||.|
  Rat   380 --------------------AKERLEENCV---------HPLEEAMLGCDVDGSRHFS---ESRN 412

  Fly   387 SGQLGPVPASPSSQPLRQGNGHGHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNS 451
            |.                                 |||||||||||||||||||||:|.||||||
  Rat   413 SS---------------------------------HIKRPMNAFMVWAKDERRKILQAFPDMHNS 444

  Fly   452 NISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMRISEYKVLM 516
            :||||||:|||:|:|.:||||||||:|||:.|:|::|||:|:|||||||:|:|:::|:.|||.||
  Rat   445 SISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCVVEGRRLRVGEYKALM 509

  Fly   517 RNRRAEMRQLWCRTGGVSGGSGSLCADACPKGSGGS--NSQVAVAAAAAVYHLQDMASSAASTAH 579
            |.||...||.:                |.|..:|.:  :|.:....||.      |..:.....|
  Rat   510 RTRRQGARQSY----------------AIPPQAGQAQVSSDILFPRAAG------MPLARPLVEH 552

  Fly   580 GHDCGHTPPQQFFYPPESLSPS 601
                         |.|:.|.|:
  Rat   553 -------------YDPQGLDPN 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	55/70 (79%)
Sox13	XP_006249824.1	Herpes_UL46	<251..>419	CDD:355696	49/294 (17%)
Sox13	XP_006249824.1	SOX-TCF_HMG-box	415..486	CDD:238684	55/70 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342366
Domainoid	1	1.000	128	1.000	Domainoid score	I5182
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44626
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45789
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5247
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890