DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and Meiosin

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_001357740.1	Gene:	Meiosin / 243866	MGIID:	3647482	Length:	589	Species:	Mus musculus

Alignment Length:	606	Identity:	122/606 - (20%)
Similarity:	200/606 - (33%)	Gaps:	209/606 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPGEDQTNEKEHSDLGMIKQLQLI--------------RNRILSQAHYDSMTDIDASAQQQQQLQ 53
            |...|:.::|.|::  .:::|.|:              :..:|...||               :|
Mouse    19 PSPTDRKDKKNHTN--KLRELALLIPVTMKTRDKKYTKKEILLRVLHY---------------IQ 66

  Fly    54 NVQR-LQHESCLQELHNHLSSQYGAVRFT--AANPQ-HQNQQAVSVSSGNLMP------------ 102
            .:|| :.....|.:||    |..|..||.  ..||. .|.||..|..|.:..|
Mouse    67 YLQRNIDMTKALLKLH----SSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKK 127

  Fly   103 -FLPAFLQPPMP-NAQQLLQLIPGHENAQSVPTHHHSHP----QSEAFSTHKMALAPMWST---- 157
             |......|..| |.::.|.|... ||..::      ||    ::|..:|:...|:|  ||
Mouse   128 KFTRVSEHPSWPYNPRRSLALDQA-ENPNTI------HPGLKEENEECATYPGVLSP--STYPTT 183

  Fly   158 -AAVAAAHIQAALAAAAVAAAN---NNKNSSHFSNNTNIVGLATRGNELLNTDSDPQMEIGETRR 218
             .:|:....|.|.......|.|   .:..|.|        .:..:|.| .|.|...|.....||.
Mouse   184 EPSVSEGDGQGAQLVFLDMAQNIFAYDILSDH--------AVEVQGGE-PNADIKVQRSFFLTRA 239

  Fly   219 GGNGGSCRSR----------PESPTYENPPYEILSYSHNTPPESPHG---------RTAD----- 259
            .....|||.:          .|:|  ::.|:..:..|.::|..||..         ..||
Mouse   240 QPCVSSCRQKLFLCTSSEADKEAP--DSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEI 302

  Fly   260 --CSKNFSPSP----------------TDNLSIASVSEAQDSEMDAPLNLSKPKGSPSSSPN--S 304
              .|.:...||                |:.|..:|.:..   |:::|.........|:..||  |
Mouse   303 LGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATC---EVESPQEKEVSSEGPTGPPNFQS 364

  Fly   305 SSQRDHC-----ENLTPVVSSPPLSWHQGQPHYAEIELPLLKSHGRVWNSAVACSGGSRATRV-- 362
            |...|||     ||: .|:|:                                |...|.:|..
Mouse   365 SVSLDHCYLSLSENV-KVLSN--------------------------------CGSSSESTDTES 396

  Fly   363 --SRDSVNSCGTNSERSAAL-----------DPESLN-------------SGQLGPVP-ASPSSQ 400
              .::.|....|...|:...           :||.|.             :||...:| ||...:
Mouse   397 LWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIK 461

  Fly   401 PLRQGNG-----HGHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGAR 460
            .::...|     .......|.|.     |:.:|.|:::.:..|::.::|||...::..:|.|...
Mouse   462 KVQASQGPVKPKDSRKACPGQVK-----KKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQL 521

  Fly   461 WKAMSNADKQPYYEEQSRLSK 481
            |:.|:..:|:||..:..|.|:
Mouse   522 WRGMTLEEKKPYCTKARRFSR 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	16/60 (27%)
Meiosin	NP_001357740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		3/11 (27%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	14..27		2/7 (29%)
		bHLH_SF	24..73	CDD:412148	10/65 (15%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	28..68		8/56 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..191		27/110 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		5/20 (25%)
		NHP6B	416..>539	CDD:227935	25/127 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..457		6/34 (18%)
		HMG-box	484..539	CDD:238037	14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900