DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox102F and Sry

DIOPT Version :9

Sequence 1:NP_001014695.1 Gene:Sox102F / 43844 FlyBaseID:FBgn0039938 Length:618 Species:Drosophila melanogaster
Sequence 2:NP_035694.1 Gene:Sry / 21674 MGIID:98660 Length:395 Species:Mus musculus


Alignment Length:197 Identity:61/197 - (30%)
Similarity:86/197 - (43%) Gaps:60/197 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   422 HIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYYEEQSRLSKLHMEQ 486
            |:||||||||||::.||.|:.:..|.|.|:.|||.||.|||:::.|:|:|:::|..||..||.|:
Mouse     4 HVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHREK 68

  Fly   487 HPDYRYRPR-----PKRTCIVDGKKMRISEYKVLM--RNRRA-EMRQLWCRTGGVSGGSGSLCAD 543
            :|:|:|:|.     .:|:.|:.........|.:|.  ||..| ..||.|.|              
Mouse    69 YPNYKYQPHRRAKVSQRSGILQPAVASTKLYNLLQWDRNPHAITYRQDWSR-------------- 119

  Fly   544 ACPKGSGGSNSQVAVAAAAAVY-----------------HLQDMASSAASTA-HGHDCGHTPPQQ 590
                             ||.:|                 |||.......... |.|   |...||
Mouse   120 -----------------AAHLYSKNQQSFYWQPVDIPTGHLQQQQQQQQQQQFHNH---HQQQQQ 164

  Fly   591 FF 592
            |:
Mouse   165 FY 166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox102FNP_001014695.1 SOX-TCF_HMG-box 422..493 CDD:238684 36/70 (51%)
SryNP_035694.1 Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066 4..81 38/76 (50%)
SOX-TCF_HMG-box 4..74 CDD:238684 36/69 (52%)
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 6..22 12/15 (80%)
Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066 52..84 11/31 (35%)
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 75..81 1/5 (20%)
Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996 92..144 13/82 (16%)
Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090 94..138 12/74 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..361 9/28 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838569
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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