DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox102F and Sox30

DIOPT Version :9

Sequence 1:	NP_001014695.1	Gene:	Sox102F / 43844	FlyBaseID:	FBgn0039938	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_775560.1	Gene:	Sox30 / 214105	MGIID:	1341157	Length:	782	Species:	Mus musculus

Alignment Length:	490	Identity:	108/490 - (22%)
Similarity:	171/490 - (34%)	Gaps:	153/490 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QPPMPNAQQLLQLIPGHENAQSVPTHHHSHPQSEAFSTHKMALAPMWSTAA----VAAAHIQAA- 168
            |||.|...:.|:..|..:..::......:..:|:  |....|.|.|.:.|:    .|||..|||
Mouse    18 QPPRPTPPRPLRPAPPAQPVEAATFRAAAAERSQ--SPSAQATAAMAAVASSCGEAAAAGAQAAG 80

  Fly   169 -----------------------------LAAAAVAAANNNKNSSHFSNNTNIVGLATRGNELLN 204
                                         .||||.|||     ::..|....::.|.
Mouse    81 TRRLLQVKPEQVLLLPPGGPGVPPAPDEGAAAAAAAAA-----AAASSAQARLLQLR-------- 132

  Fly   205 TDSDPQMEIGETRRGGNGGSCR-----SRPESPTYENPPYEI-----LSY-SHNTPPESPH---- 254
                |::.:...:...:||.||     .:|.:...:....|:     ||. |..|....|.
Mouse   133 ----PELLLLPPQSAADGGPCRPELHPMQPRTLLVKAEKQELGAGLDLSVGSRRTTEAGPRASRA 193

  Fly   255 -----------GRTADCSK---NFSPSPTDNL------SIASVSEA--QDSEMDAPLNLSKPKGS 297
                       ||.:|..|   ....:|.|.|      |:.::.|.  :..|.|.|
Mouse   194 AKLDGTGKALDGRRSDEKKAKLEAEEAPRDALKGGEGKSLLAIGEGVIKTEEPDRP--------- 249

  Fly   298 PSSSPNSSSQRDHC-------------ENLTPVVSSPPLSWHQGQPHYAEIELPLLKSHGRVWNS 349
                      ||.|             .:...:::.||.::   .||..::..| |..|.....:
Mouse   250 ----------RDDCRLGTEATSNGLVHSSKEAILAQPPSAF---GPHQQDLRFP-LTLHTVPPGA 300

  Fly   350 AVACSGGSRATRVSRDSVNSCGTNSERSAALDPESLNSGQLGPVPASPSSQPL------RQGNGH 408
            .:...|...:..:....|.......:..:.|:|......:..|:...||...:      :..||
Mouse   301 RIQFQGPPPSELIRLSKVPLTPVPIKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNG- 364

  Fly   409 GHGGNHGHVHSKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNADKQPYY 473
                         |:|||||||||||:..|..:.||.|..:|:.||..||..|..:|...|:|||
Mouse   365 -------------HVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYY 416

  Fly   474 EEQSRLSKLHMEQHPDYRYRPRPKRTCIVDGKKMR 508
            :|..::.:.|.|:.|.:.|:|||       ||:.|
Mouse   417 DEAQKIKEKHREEFPGWVYQPRP-------GKRKR 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox102F	NP_001014695.1	SOX-TCF_HMG-box	422..493	CDD:238684	31/70 (44%)
Sox30	NP_775560.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..117		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..226		17/86 (20%)
		SOX-TCF_HMG-box	365..435	CDD:238684	31/69 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..724
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810